Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, alpha V | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | integrin alpha ps | integrin, alpha V | 1002 aa | 908 aa | 22.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.1189 | 0.1189 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0346 | 0.1945 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.0616 | 0.3464 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0087 | 0.0032 | 0.0032 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.014 | 0.0346 | 0.1945 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0424 | 0.2051 | 0.1088 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0087 | 0.0032 | 0.0219 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0087 | 0.0032 | 0.0178 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.1216 | 0.684 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0087 | 0.0032 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.0446 | 0.3076 |
Schistosoma mansoni | integrin alpha-ps | 0.0083 | 0.0004 | 0.0029 |
Echinococcus multilocularis | geminin | 0.0156 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | twinkle helicase | 0.0092 | 0.0062 | 0.0349 |
Schistosoma mansoni | Replicative DNA helicase | 0.0323 | 0.1449 | 1 |
Echinococcus multilocularis | integrin alpha 3 | 0.0142 | 0.0357 | 0.0357 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.0323 | 0.1449 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0087 | 0.0032 | 0.0267 |
Echinococcus granulosus | geminin | 0.0156 | 0.0446 | 0.3749 |
Wolbachia endosymbiont of Brugia malayi | 6,7-dimethyl-8-ribityllumazine synthase | 0.1247 | 0.6989 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0087 | 0.0032 | 0.0219 |
Mycobacterium leprae | Probable riboflavin synthase beta chain RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (Lumazine synthase). | 0.1247 | 0.6989 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0083 | 0.0004 | 0.0004 |
Echinococcus granulosus | integrin alpha 3 | 0.0142 | 0.0357 | 0.3002 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0087 | 0.0032 | 0.0178 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.0446 | 0.3076 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0378 | 0.2124 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0119 | 0.0669 |
Onchocerca volvulus | 0.0082 | 0 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0087 | 0.0032 | 0.0267 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.1441 | 0.8153 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0083 | 0.0004 | 0.0036 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.1777 | 1 |
Chlamydia trachomatis | 7-dimethyl-8-ribityllumazine synthase | 0.1247 | 0.6989 | 1 |
Mycobacterium tuberculosis | Probable riboflavin synthase beta chain RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (lumazine synthase) | 0.1247 | 0.6989 | 0.4003 |
Mycobacterium ulcerans | 6,7-dimethyl-8-ribityllumazine synthase | 0.1247 | 0.6989 | 1 |
Schistosoma mansoni | integrin alpha | 0.0185 | 0.0616 | 0.4249 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0087 | 0.0032 | 0.0219 |
Echinococcus multilocularis | integrin alpha ps | 0.0083 | 0.0004 | 0.0004 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.1189 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.1777 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.0844 | 0.5826 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15.1 nM | Displacement of [125I]echistatin from integrin alphaVbeta5 receptor in human placenta by microplate scintillation counter | ChEMBL. | 19195898 |
IC50 (binding) | = 157 nM | Displacement of [125I]echistatin from integrin alphaVbeta3 receptor in human placenta by microplate scintillation counter | ChEMBL. | 19195898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.