Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0549 | 0.7464 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0716 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0716 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0549 | 0.7464 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0549 | 0.7464 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0549 | 0.7464 | 1 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0549 | 0.7464 | 0.7464 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0145 | 0.1342 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.016 | 0.016 |
Onchocerca volvulus | 0.0549 | 0.7464 | 1 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0549 | 0.7464 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0202 | 0.2207 | 0.208 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0549 | 0.7464 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0169 | 0.1706 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0716 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Onchocerca volvulus | 0.0145 | 0.1342 | 0.1618 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0169 | 0.1706 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.136 | 0.136 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0169 | 0.1706 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0169 | 0.1706 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0716 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.016 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.016 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.2065 | 0.2065 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.1342 | 0.1201 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0549 | 0.7464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.136 | 0.136 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.038 | 0.4898 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0549 | 0.7464 | 1 |
Onchocerca volvulus | 0.0156 | 0.1503 | 0.1838 | |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0549 | 0.7464 | 0.7422 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0145 | 0.1342 | 0.1342 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.136 | 0.136 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0549 | 0.7464 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0549 | 0.7464 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0067 | 0.016 | 0.016 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.6 ug ml-1 | Cytotoxicity against human SK-MEL-2 cells | ChEMBL. | 11170665 |
ED50 (functional) | = 0.8 ug ml-1 | Cytotoxicity against human SKOV3 cells | ChEMBL. | 11170665 |
ED50 (functional) | = 0.8 ug ml-1 | Cytotoxicity against human HCT15 cells | ChEMBL. | 11170665 |
ED50 (functional) | = 1.3 ug ml-1 | Cytotoxicity against human XF498 cells | ChEMBL. | 11170665 |
ED50 (functional) | = 1.8 ug ml-1 | Cytotoxicity against human A549 cells | ChEMBL. | 11170665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.