Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | GMP reductase | 0.0134 | 0.054 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1168 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0134 | 0.054 | 0.5 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0134 | 0.054 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0134 | 0.054 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 0.054 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.0134 | 0.054 | 0.5 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 0.054 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1168 | 1 | 1 |
Trypanosoma brucei | GMP reductase | 0.0134 | 0.054 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0134 | 0.054 | 0.2072 |
Trypanosoma cruzi | GMP reductase | 0.0134 | 0.054 | 0.5 |
Mycobacterium tuberculosis | ATP phosphoribosyltransferase HisG | 0.036 | 0.2608 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0134 | 0.054 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0134 | 0.054 | 0.2072 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1168 | 1 | 1 |
Mycobacterium leprae | Probable ATP phosphoribosyltransferase HisG | 0.036 | 0.2608 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1168 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.0168 | 0.0854 | 0.0332 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 0.054 | 0.5 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0134 | 0.054 | 0.5 |
Mycobacterium ulcerans | ATP phosphoribosyltransferase | 0.036 | 0.2608 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 0.054 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 80 nM | Inhibition of Cryptosporidium parvum IMPDH assessed as reduction in NADH production | ChEMBL. | 25474504 |
Inhibition (binding) | < 20 % | Inhibition of human IMPDH2 assessed as reduction in NADH production at 5 uM | ChEMBL. | 25474504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.