Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.5863 | 0.5863 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0616 | 0.5863 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0616 | 0.5863 | 0.5863 |
Echinococcus granulosus | FTZ F1 alpha | 0.0616 | 0.5863 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0616 | 0.5863 | 0.5752 |
Brugia malayi | hexokinase | 0.0457 | 0.2803 | 0.2611 |
Entamoeba histolytica | hexokinase 1 | 0.0457 | 0.2803 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0616 | 0.5863 | 0.5752 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0616 | 0.5863 | 0.5752 |
Schistosoma mansoni | nuclear hormone receptor | 0.0616 | 0.5863 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0616 | 0.5863 | 0.5752 |
Echinococcus multilocularis | hexokinase | 0.0457 | 0.2803 | 0.4539 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0616 | 0.5863 | 0.5752 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0616 | 0.5863 | 1 |
Schistosoma mansoni | hexokinase | 0.0457 | 0.2803 | 0.4539 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0616 | 0.5863 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0616 | 0.5863 | 0.5752 |
Leishmania major | hexokinase, putative | 0.0457 | 0.2803 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0457 | 0.2803 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0616 | 0.5863 | 0.5863 |
Echinococcus granulosus | hexokinase type 2 | 0.0457 | 0.2803 | 0.4539 |
Echinococcus granulosus | hexokinase | 0.0457 | 0.2803 | 0.4539 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0616 | 0.5863 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0457 | 0.2803 | 0.2803 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0616 | 0.5863 | 1 |
Plasmodium falciparum | hexokinase | 0.0457 | 0.2803 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0616 | 0.5863 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0616 | 0.5863 | 0.5752 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0616 | 0.5863 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0616 | 0.5863 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0616 | 0.5863 | 0.5752 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.5863 | 0.5863 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0616 | 0.5863 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0616 | 0.5863 | 1 |
Echinococcus granulosus | hexokinase | 0.0457 | 0.2803 | 0.4539 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0616 | 0.5863 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0457 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.026 | 0.026 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0616 | 0.5863 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0616 | 0.5863 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0457 | 0.2803 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0616 | 0.5863 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0616 | 0.5863 | 0.5863 |
Loa Loa (eye worm) | hexokinase type II | 0.0457 | 0.2803 | 0.2803 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0765 | 0.8728 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0616 | 0.5863 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0439 | 0.2454 | 0.2454 |
Brugia malayi | nuclear hormone receptor | 0.0439 | 0.2454 | 0.2252 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.5863 | 0.5863 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0616 | 0.5863 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0831 | 1 | 1 |
Onchocerca volvulus | 0.0616 | 0.5863 | 0.5164 | |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.026 | 0.026 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0616 | 0.5863 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0326 | 0.026 | 0.026 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0616 | 0.5863 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0616 | 0.5863 | 0.5752 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0616 | 0.5863 | 0.5752 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.026 | 0.026 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0616 | 0.5863 | 0.5863 |
Toxoplasma gondii | hexokinase | 0.0457 | 0.2803 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0616 | 0.5863 | 0.5164 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0616 | 0.5863 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0616 | 0.5863 | 1 |
Brugia malayi | Hexokinase family protein | 0.0457 | 0.2803 | 0.2611 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0616 | 0.5863 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0616 | 0.5863 | 0.5863 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0616 | 0.5863 | 0.5863 |
Echinococcus multilocularis | hexokinase | 0.0457 | 0.2803 | 0.4539 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.5863 | 0.5863 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0616 | 0.5863 | 0.5752 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0616 | 0.5863 | 0.5752 |
Echinococcus multilocularis | hexokinase type 2 | 0.0457 | 0.2803 | 0.4539 |
Brugia malayi | nuclear receptor NHR-88 | 0.0616 | 0.5863 | 0.5752 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0616 | 0.5863 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0457 | 0.2803 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0616 | 0.5863 | 0.5752 |
Echinococcus granulosus | hexokinase | 0.0457 | 0.2803 | 0.4539 |
Treponema pallidum | hexokinase (hxk) | 0.0457 | 0.2803 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0616 | 0.5863 | 0.5752 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0616 | 0.5863 | 0.5752 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0505 | 0.3726 | 0.6185 |
Leishmania major | hexokinase, putative | 0.0457 | 0.2803 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.5863 | 0.5863 |
Schistosoma mansoni | thyroid hormone receptor | 0.0616 | 0.5863 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0616 | 0.5863 | 0.5164 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0616 | 0.5863 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.5863 | 0.5863 |
Trypanosoma cruzi | hexokinase, putative | 0.0457 | 0.2803 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0457 | 0.2803 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0616 | 0.5863 | 0.5752 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.026 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.5863 | 0.5863 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0616 | 0.5863 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0616 | 0.5863 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0616 | 0.5863 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0616 | 0.5863 | 0.5863 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.5863 | 0.5863 |
Trypanosoma brucei | hexokinase, putative | 0.0457 | 0.2803 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0616 | 0.5863 | 0.5752 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.026 | 0.026 |
Echinococcus multilocularis | hexokinase | 0.0457 | 0.2803 | 0.4539 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0616 | 0.5863 | 0.5752 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0616 | 0.5863 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0616 | 0.5863 | 1 |
Trypanosoma brucei | hexokinase | 0.0457 | 0.2803 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | Antibacterial activity against Escherichia coli at 1 mg/ml by agar well diffusion method | ChEMBL. | 18804313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.