Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0411 | 0.1187 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.0202 | 0.0481 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0097 | 0.0973 | 0.4719 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0328 | 0.4052 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0773 | 1 | 1 |
Trichomonas vaginalis | dexras1, putative | 0.0064 | 0.0541 | 0.0639 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0338 | 0.4198 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0328 | 0.4052 | 1 |
Leishmania major | trypanothione reductase | 0.0042 | 0.0248 | 0.0591 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0212 | 0.2505 | 0.8914 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0151 | 0.0083 |
Onchocerca volvulus | 0.004 | 0.0221 | 0.0297 | |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0107 | 0.1117 | 0.5418 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0328 | 0.4052 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0328 | 0.4052 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0043 | 0.0256 | 0.0128 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0043 | 0.0256 | 0.0145 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.016 | 0.1817 | 1 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0064 | 0.0541 | 0.1546 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0718 |
Brugia malayi | hypoxia-induced factor 1 | 0.0169 | 0.1934 | 0.6771 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0338 | 0.4198 | 1 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0158 | 0.1796 | 0.3918 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0718 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0338 | 0.4198 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0169 | 0.1934 | 0.6771 |
Echinococcus granulosus | dna polymerase kappa | 0.0046 | 0.0301 | 0.0191 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0212 | 0.2505 | 1 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0053 | 0.0392 | 0.0933 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0158 | 0.1796 | 0.4277 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0042 | 0.0248 | 0.1203 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0064 | 0.0541 | 0.0639 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0058 | 0.0456 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.2123 | 0.748 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0718 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0048 | 0.0317 | 0.0176 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0107 | 0.1117 | 0.5418 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0055 | 0.041 | 0.0285 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0135 |
Onchocerca volvulus | 0.0265 | 0.3224 | 1 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.016 | 0.1819 | 0.3978 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0328 | 0.4052 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0048 | 0.0317 | 0.0756 |
Toxoplasma gondii | thioredoxin reductase | 0.0042 | 0.0248 | 0.0502 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0718 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0328 | 0.4052 | 1 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0212 | 0.2505 | 0.242 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0135 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0097 | 0.0973 | 0.4719 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0107 | 0.1117 | 0.1705 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0328 | 0.4052 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0718 |
Plasmodium vivax | topoisomerase I, putative | 0.0212 | 0.2505 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0718 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0328 | 0.4052 | 1 |
Trypanosoma brucei | unspecified product | 0.0039 | 0.0202 | 0.0481 |
Brugia malayi | PAS domain containing protein | 0.0055 | 0.041 | 0.1054 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0097 | 0.0973 | 0.4719 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0107 | 0.1117 | 0.5418 |
Mycobacterium ulcerans | hypothetical protein | 0.0178 | 0.2061 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.0301 | 0.0718 |
Brugia malayi | glutathione reductase | 0.0042 | 0.0248 | 0.0447 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0042 | 0.0248 | 0.0447 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0046 | 0.0301 | 0.0438 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0338 | 0.4198 | 1 |
Echinococcus granulosus | ras gtpase | 0.0064 | 0.0541 | 0.0433 |
Trichomonas vaginalis | ral, putative | 0.0064 | 0.0541 | 0.0639 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0097 | 0.0973 | 0.4719 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.016 | 0.1817 | 0.8817 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.0301 | 0.0718 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0129 | 0.0017 |
Trichomonas vaginalis | rheb, putative | 0.0064 | 0.0541 | 0.0639 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0328 | 0.4052 | 1 |
Brugia malayi | DNA topoisomerase I | 0.0212 | 0.2505 | 0.8914 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0328 | 0.4052 | 1 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0064 | 0.0541 | 0.1546 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0158 | 0.1796 | 0.4277 |
Brugia malayi | Thioredoxin reductase | 0.0042 | 0.0248 | 0.0447 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0158 | 0.1796 | 0.1689 |
Brugia malayi | polk-prov protein | 0.0035 | 0.0151 | 0.0083 |
Trichomonas vaginalis | set domain proteins, putative | 0.0265 | 0.3224 | 0.7792 |
Echinococcus granulosus | single minded 2 | 0.004 | 0.0221 | 0.011 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0064 | 0.0541 | 0.0639 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.016 | 0.1817 | 0.8675 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0046 | 0.0301 | 0.0438 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0097 | 0.0973 | 0.4719 |
Brugia malayi | Ras protein let-60 | 0.0064 | 0.0541 | 0.1546 |
Brugia malayi | Pre-SET motif family protein | 0.0233 | 0.2794 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.016 | 0.1819 | 0.4334 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0212 | 0.2505 | 0.2407 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0233 | 0.2794 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0048 | 0.0317 | 0.0176 |
Trichomonas vaginalis | rap1 and, putative | 0.0064 | 0.0541 | 0.0639 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0773 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0042 | 0.0248 | 0.0591 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.016 | 0.1819 | 0.4334 |
Brugia malayi | bHLH-PAS transcription factor | 0.004 | 0.0221 | 0.0345 |
Plasmodium falciparum | topoisomerase I | 0.0212 | 0.2505 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0046 | 0.0301 | 0.0175 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0042 | 0.0248 | 0.0502 |
Echinococcus multilocularis | transfer RNA-Lys | 0.004 | 0.0221 | 0.0093 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0135 |
Mycobacterium tuberculosis | Probable reductase | 0.0097 | 0.0973 | 0.4719 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0053 | 0.0392 | 0.0363 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0158 | 0.1796 | 0.1689 |
Schistosoma mansoni | single-minded | 0.0055 | 0.041 | 0.0285 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0328 | 0.4052 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0135 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0212 | 0.2505 | 0.2407 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0718 |
Brugia malayi | hypothetical protein | 0.0183 | 0.2123 | 0.748 |
Loa Loa (eye worm) | glutathione reductase | 0.0042 | 0.0248 | 0.0447 |
Echinococcus multilocularis | ras gtpase | 0.0064 | 0.0541 | 0.0418 |
Leishmania major | DNA topoisomerase type IB small subunit | 0.0053 | 0.0392 | 0.0933 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0035 | 0.0151 | 0.0359 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0541 | 0.1546 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0178 | 0.2061 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0042 | 0.0248 | 0.0502 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0048 | 0.0317 | 0.0176 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0718 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0328 | 0.4052 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0035 | 0.0151 | 0.0359 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0301 | 0.0718 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 5.5 ug ml-1 | Cytotoxicity against human KB cells | ChEMBL. | 3210017 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.