Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.3862 | 0.5953 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.5675 | 1 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.5675 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2053 | 0.1915 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.2053 | 0.1915 | 0.3117 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.5675 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.5675 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2075 | 0.1964 | 0.32 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.5675 | 1 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.3862 | 0.5953 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.2075 | 0.1964 | 0.3299 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.5675 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.1234 | 0.0086 | 0.0145 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.2075 | 0.1964 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.3862 | 0.5953 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.3862 | 0.5953 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.5675 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2053 | 0.1915 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.2075 | 0.1964 | 0.32 |
Echinococcus granulosus | epidermal growth factor receptor | 0.2075 | 0.1964 | 0.32 |
Echinococcus granulosus | epidermal growth factor receptor | 0.3862 | 0.5953 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.1234 | 0.0086 | 0.0145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GC50 (functional) | = 2.7 uM | Cytotoxicity against human HeLa cells | ChEMBL. | 18082913 |
GI50 (functional) | = 2.481 | Antiproliferative activity against Homo sapiens (human) SKHEP1 cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.