Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trypanosoma brucei | trans-sialidase, putative | 0.028 | 0.2289 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1129 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.028 | 0.2289 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.1113 | 0.9858 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.028 | 0.2289 | 0.9998 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Onchocerca volvulus | 4.1 G protein, putative homolog | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1129 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1129 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.0899 | 0.0899 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0029 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0692 | 0.6032 | 0.6119 |
Trypanosoma cruzi | trans-sialidase, putative | 0.028 | 0.2289 | 0.9998 |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.028 | 0.2289 | 0.9998 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trypanosoma brucei | trans-sialidase, putative | 0.028 | 0.2289 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.028 | 0.2289 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.028 | 0.2289 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.028 | 0.2289 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1129 | 1 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trypanosoma brucei | trans-sialidase | 0.028 | 0.2289 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trypanosoma brucei | trans-sialidase, putative | 0.028 | 0.2289 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.028 | 0.2289 | 0.9998 |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.1113 | 0.9858 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.0899 | 0.0899 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.028 | 0.2289 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.0899 | 0.0899 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, putative | 0.028 | 0.2289 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.