TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 517.444 | Formula: C22H17F6N3O3S
H donors: 1 H acceptors: 3 LogP: 6.05 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: CCc1c(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)nc([nH]c1=O)SCc1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C22H17F6N3O3S/c1-2-17-18(9-13-7-14(21(23,24)25)10-15(8-13)22(26,27)28)29-20(30-19(17)32)35-11-12-3-5-16(6-4-12)31(33)34/h3-8,10H,2,9,11H2,1H3,(H,29,30,32)
InChiKey: ZEWLQOODLJVDAO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	biogenic amine 5HT receptor	0.005	0.2082	0.2082
Echinococcus multilocularis	fmrfamide receptor	0.005	0.2082	0.2082
Brugia malayi	putative neuropeptide receptor	0.005	0.2082	0.2082
Echinococcus multilocularis	neuropeptide s receptor	0.005	0.2082	0.2082
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0067	0.3054	0.3054
Brugia malayi	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.005	0.2082	0.2082
Echinococcus granulosus	g-protein coupled receptor	0.005	0.2082	0.2082
Brugia malayi	larval opioid receptor	0.005	0.2082	0.2082
Schistosoma mansoni	amine GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.005	0.2082	0.2082
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.3054	0.3054
Echinococcus granulosus	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.3054	0.3054
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.005	0.2082	0.2082
Brugia malayi	hypothetical protein	0.0031	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.005	0.2082	0.2082
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0042	0.1605	0.1605
Echinococcus multilocularis	g protein coupled receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	LGC-31 protein	0.0067	0.3054	0.3054
Brugia malayi	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	ACC-1 protein	0.0067	0.3054	0.3054
Schistosoma mansoni	nAChR subunit	0.0067	0.3054	0.3054
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0067	0.3054	0.3054
Echinococcus multilocularis	fmrfamide receptor	0.005	0.2082	0.2082
Schistosoma mansoni	amine GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	G-protein coupled receptor	0.005	0.2082	0.2082
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.3054	0.3054
Schistosoma mansoni	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	RE15519p	0.005	0.2082	0.2082
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.1812	0.1812
Schistosoma mansoni	histamine h1 receptor	0.005	0.2082	0.2082
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.3054	0.3054
Echinococcus multilocularis	neuropeptide receptor	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Echinococcus granulosus	glycine receptor subunit beta	0.0067	0.3054	0.3054
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	Cation transporter family protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.005	0.2082	0.2082
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0031	0.0976	0.0976
Schistosoma mansoni	nAChR subunit	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.1307	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Onchocerca volvulus		0.005	0.2082	0.5326
Echinococcus multilocularis	somatostatin receptor	0.005	0.2082	0.2082
Brugia malayi	Serine/threonine-protein kinase SULU	0.0187	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.3054	0.3054
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1275	0.1275
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.005	0.2082	0.2082
Echinococcus multilocularis	serine:threonine protein kinase TAO1	0.0187	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.005	0.2082	0.2082
Echinococcus granulosus	tm gpcr rhodopsin	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	biogenic amine (5HT) receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.005	0.2082	0.2082
Brugia malayi	hypothetical protein	0.0031	0.0976	0.0976
Brugia malayi	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	acetylcholine receptor-related	0.0031	0.0976	0.0976
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.005	0.2082	0.2082
Schistosoma mansoni	neuropeptide receptor	0.005	0.2082	0.2082
Onchocerca volvulus		0.0036	0.1275	0.1438
Echinococcus multilocularis	neuropeptide Y receptor	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus multilocularis	orexin receptor type 2	0.005	0.2082	0.2082
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus multilocularis	glycine receptor subunit beta	0.0067	0.3054	0.3054
Onchocerca volvulus		0.0067	0.3054	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1275	0.1275
Schistosoma mansoni	opsin-like receptor	0.005	0.2082	0.2082
Echinococcus granulosus	neuropeptide s receptor	0.005	0.2082	0.2082
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.3054	0.3054
Echinococcus multilocularis	neuropeptides capa receptor	0.005	0.2082	0.2082
Echinococcus granulosus	tachykinin peptides receptor 99D	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.005	0.2082	0.2082
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0067	0.3054	0.3054
Onchocerca volvulus		0.005	0.2082	0.5326
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0067	0.3054	0.3054
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.3054	0.3054
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.3054	0.3054
Echinococcus multilocularis	neuropeptide Y receptor	0.005	0.2082	0.2082
Brugia malayi	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0067	0.3054	0.3054
Schistosoma mansoni	neuropeptide F-like receptor	0.005	0.2082	0.2082
Schistosoma mansoni	alpha-1 adrenergic receptor	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.005	0.2082	0.2082
Entamoeba histolytica	hypothetical protein	0.0036	0.1275	0.5
Brugia malayi	neuropeptide F receptor	0.005	0.2082	0.2082
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1275	0.1275
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	ORL1-like opioid receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1306	0.1306
Echinococcus multilocularis	dro:myosuppressin receptor	0.005	0.2082	0.2082
Onchocerca volvulus		0.0067	0.3054	1
Brugia malayi	Serotonin receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	AKH receptor	0.005	0.2082	0.2082
Echinococcus multilocularis	serotonin receptor	0.005	0.2082	0.2082
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.005	0.2082	0.2082
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.3054	0.3054
Echinococcus multilocularis	G-protein coupled receptor, putative	0.005	0.2082	0.2082
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0036	0.1275	0.1275
Loa Loa (eye worm)	melatonin receptor type 1A	0.005	0.2082	0.2082
Onchocerca volvulus		0.0067	0.3054	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0067	0.3054	0.3054
Brugia malayi	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Schistosoma mansoni	nAChR subunit	0.0031	0.0976	0.0976
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0067	0.3054	0.3054
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0031	0.0976	0.0976
Brugia malayi	G protein-coupled receptor F59B2.13	0.005	0.2082	0.2082
Onchocerca volvulus		0.0067	0.3054	1
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0067	0.3054	0.3054
Echinococcus granulosus	neuropeptide receptor	0.005	0.2082	0.2082
Schistosoma mansoni	growth hormone secretagogue receptor	0.005	0.2082	0.2082
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.005	0.2082	0.5326
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.005	0.2082	0.2082
Echinococcus multilocularis	nAChR subunit	0.0067	0.3054	0.3054
Schistosoma mansoni	neurotransmitter gated ion channel	0.0031	0.0976	0.0976
Schistosoma mansoni	nAChR subunit	0.0067	0.3054	0.3054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	biogenic amine receptor	0.005	0.2082	0.2082
Brugia malayi	G protein-coupled receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.005	0.2082	0.2082
Echinococcus granulosus	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Echinococcus multilocularis	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.005	0.2082	0.2082
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0067	0.3054	0.3054
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0036	0.1275	0.1275
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0067	0.3054	0.3054
Loa Loa (eye worm)	neuropeptide F receptor	0.005	0.2082	0.2082
Echinococcus multilocularis	neuropeptide FF receptor 2	0.005	0.2082	0.2082
Loa Loa (eye worm)	ACC-1 protein	0.0067	0.3054	0.3054
Schistosoma mansoni	neuropeptide F-like receptor	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Echinococcus granulosus	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.005	0.2082	0.2082
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.005	0.2082	0.2082
Brugia malayi	GnHR receptor homolog	0.005	0.2082	0.2082
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.005	0.2082	0.2082
Schistosoma mansoni	neuropeptide f receptor 76f	0.005	0.2082	0.2082
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.005	0.2082	0.2082
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0067	0.3054	0.3054
Onchocerca volvulus	Neuropeptide F receptor homolog	0.005	0.2082	0.5326
Schistosoma mansoni	nAChR subunit	0.0067	0.3054	0.3054
Schistosoma mansoni	myosin xvIII	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1275	0.1275
Loa Loa (eye worm)	neuropeptide F receptor	0.005	0.2082	0.2082
Echinococcus granulosus	fmrfamide receptor	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.005	0.2082	0.2082
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.1307	0.5
Schistosoma mansoni	biogenic amine receptor	0.005	0.2082	0.2082
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Echinococcus granulosus	glycine receptor subunit beta	0.0067	0.3054	0.3054
Brugia malayi	Dopamine receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.005	0.2082	0.2082
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.005	0.2082	0.2082
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0031	0.0976	0.0976
Onchocerca volvulus		0.0067	0.3054	1
Brugia malayi	hypothetical protein	0.0031	0.0976	0.0976
Schistosoma mansoni	neuropeptide receptor	0.005	0.2082	0.2082
Brugia malayi	Cation transporter family protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1275	0.1275
Onchocerca volvulus		0.005	0.2082	0.5326
Schistosoma mansoni	nAChR subunit	0.0067	0.3054	0.3054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0067	0.3054	0.3054
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0031	0.0976	0.0976
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Echinococcus granulosus	tm gpcr rhodopsin	0.005	0.2082	0.2082
Echinococcus granulosus	neuropeptide FF receptor 2	0.005	0.2082	0.2082
Echinococcus granulosus	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.3054	0.3054
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0067	0.3054	0.3054
Brugia malayi	Melatonin receptor type 1A	0.005	0.2082	0.2082
Echinococcus granulosus	7TM GPCR rhodopsin	0.005	0.2082	0.2082
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0036	0.1275	0.1275
Brugia malayi	Cation transporter family protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus granulosus	biogenic amine 5HT receptor	0.005	0.2082	0.2082
Echinococcus granulosus	sodium channel protein	0.0042	0.1643	0.1643
Echinococcus granulosus	neuropeptide receptor	0.005	0.2082	0.2082
Echinococcus multilocularis	neuropeptide receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0067	0.3054	0.3054
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.005	0.2082	0.2082
Echinococcus granulosus	orexin receptor type 2	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	GABA receptor subunit	0.0036	0.1275	0.1275
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.005	0.2082	0.2082
Echinococcus granulosus	neuropeptides capa receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.005	0.2082	0.2082
Schistosoma mansoni	neuropeptide receptor	0.005	0.2082	0.2082
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0031	0.0976	0.0976
Echinococcus multilocularis	allatostatin A receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus multilocularis	neuropeptides capa receptor	0.005	0.2082	0.2082
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0067	0.3054	0.3054
Echinococcus multilocularis	sodium channel protein	0.0042	0.1643	0.1643
Loa Loa (eye worm)	acetylcholine receptor protein	0.0031	0.0976	0.0976
Schistosoma mansoni	opsin-like receptor	0.005	0.2082	0.2082
Echinococcus granulosus	neuropeptides capa receptor	0.005	0.2082	0.2082
Brugia malayi	hypothetical protein	0.0031	0.0976	0.0976
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.005	0.2082	0.2082
Echinococcus granulosus	7tm_1 domain containing protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0067	0.3054	0.3054
Schistosoma mansoni	nAChR subunit	0.0067	0.3054	0.3054
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.005	0.2082	0.2082
Schistosoma mansoni	neurotransmitter gated ion channel	0.0036	0.1275	0.1275
Schistosoma mansoni	hypothetical protein	0.005	0.2082	0.2082
Echinococcus multilocularis	neuropeptide receptor A26	0.005	0.2082	0.2082
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0042	0.1605	0.1605
Echinococcus multilocularis	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	TYRA-2 protein	0.005	0.2082	0.2082
Echinococcus granulosus	peptide allatostatin:somatostatin	0.005	0.2082	0.2082
Schistosoma mansoni	neurotransmitter gated ion channel	0.0031	0.0976	0.0976
Onchocerca volvulus		0.0067	0.3054	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.005	0.2082	0.2082
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.3054	0.3054
Onchocerca volvulus	Putative nachr subunit	0.0067	0.3054	1
Brugia malayi	Dopamine receptor protein 1	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Schistosoma mansoni	amine GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Echinococcus granulosus	neuropeptide Y receptor	0.005	0.2082	0.2082
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0067	0.3054	0.3054
Echinococcus multilocularis	serotonin receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus granulosus	alpha 1A adrenergic receptor	0.005	0.2082	0.2082
Schistosoma mansoni	biogenic amine receptor	0.005	0.2082	0.2082
Echinococcus multilocularis	sex peptide receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.005	0.2082	0.2082
Brugia malayi	G-protein coupled receptor	0.005	0.2082	0.2082
Echinococcus granulosus	nAChR subunit	0.0067	0.3054	0.3054
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.005	0.2082	0.2082
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0031	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	neuropeptide receptor	0.005	0.2082	0.2082
Echinococcus granulosus	serine:threonine protein kinase TAO1	0.0187	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.0187	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.3054	0.3054
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.3054	0.3054
Brugia malayi	sulfakinin receptor protein	0.005	0.2082	0.2082
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0067	0.3054	0.3054
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0067	0.3054	0.3054
Brugia malayi	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1275	0.1275
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.3054	0.3054
Echinococcus granulosus	neuropeptide receptor A26	0.005	0.2082	0.2082
Echinococcus multilocularis	glycine receptor subunit beta	0.0067	0.3054	0.3054
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.005	0.2082	0.2082
Echinococcus granulosus	serotonin receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	excitatory GABA receptor EXP-1A	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Echinococcus multilocularis	g protein coupled receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus granulosus	g protein coupled receptor	0.005	0.2082	0.2082
Echinococcus granulosus	g protein coupled receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	amine GPCR	0.005	0.2082	0.2082
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0067	0.3054	0.3054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.005	0.2082	0.2082
Echinococcus multilocularis	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0031	0.0976	0.0976
Onchocerca volvulus		0.005	0.2082	0.5326
Brugia malayi	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.005	0.2082	0.2082
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0067	0.3054	0.3054
Echinococcus granulosus	dro:myosuppressin receptor	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.005	0.2082	0.2082
Echinococcus granulosus	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Onchocerca volvulus		0.005	0.2082	0.5326
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1275	0.1275
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Echinococcus multilocularis	G protein coupled receptor 139	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	hypothetical protein	0.005	0.2082	0.2082
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0031	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1275	0.1275
Onchocerca volvulus		0.005	0.2082	0.5326
Echinococcus granulosus	sex peptide receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.005	0.2082	0.2082
Echinococcus granulosus	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	hypothetical protein	0.0031	0.0976	0.0976
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0036	0.1275	0.1275
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.3054	0.3054
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0067	0.3054	0.3054
Schistosoma mansoni	opsin-like receptor	0.005	0.2082	0.2082
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0067	0.3054	0.3054
Brugia malayi	follicle stimulating hormone receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0067	0.3054	0.3054
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0042	0.1643	0.5
Schistosoma mansoni	amine GPCR	0.005	0.2082	0.2082
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0031	0.0976	0.0976
Brugia malayi	Dopamine receptor protein 2	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1275	0.1275
Echinococcus multilocularis	g-protein coupled receptor	0.005	0.2082	0.2082
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.005	0.2082	0.2082
Echinococcus granulosus	G protein coupled receptor 139	0.005	0.2082	0.2082
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.005	0.2082	0.2082
Onchocerca volvulus		0.0036	0.1275	0.1438
Loa Loa (eye worm)	G-protein coupled receptor	0.005	0.2082	0.2082
Echinococcus granulosus	nAChR subunit	0.0036	0.1275	0.1275
Echinococcus multilocularis	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0036	0.1275	0.1275
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0067	0.3054	0.3054
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0031	0.0976	0.0976
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.1812	0.1812
Echinococcus granulosus	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0042	0.1605	0.1605
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Echinococcus multilocularis	g protein coupled receptor	0.005	0.2082	0.2082
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.3054	0.3054
Echinococcus granulosus	somatostatin receptor	0.005	0.2082	0.2082
Schistosoma mansoni	adenoreceptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Echinococcus multilocularis	nAChR subunit	0.0036	0.1275	0.1275
Schistosoma mansoni	serine/threonine protein kinase	0.0187	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0042	0.1605	0.1605
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0031	0.0976	0.0976
Echinococcus granulosus	allatostatin A receptor	0.005	0.2082	0.2082
Echinococcus granulosus	neuropeptide Y receptor	0.005	0.2082	0.2082
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0031	0.0976	0.0976
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0031	0.0976	0.0976
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.005	0.2082	0.2082
Echinococcus granulosus	g protein coupled receptor	0.005	0.2082	0.2082
Echinococcus granulosus	tm gpcr rhodopsin	0.005	0.2082	0.2082
Schistosoma mansoni	hypothetical protein	0.0055	0.2364	0.2364
Schistosoma mansoni	nAChR subunit	0.0031	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0036	0.1275	0.1275
Brugia malayi	Tachykinin-like peptides receptor 99D	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Echinococcus granulosus	rhodopsin orphan GPCR	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0067	0.3054	0.3054
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	hypothetical protein	0.005	0.2082	0.2082
Brugia malayi	hypothetical protein	0.005	0.2082	0.2082
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.005	0.2082	0.2082
Schistosoma mansoni	nAChR subunit	0.0067	0.3054	0.3054
Brugia malayi	Serotonin receptor	0.005	0.2082	0.2082
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0031	0.0976	0.0976
Brugia malayi	G-protein coupled receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.2082	0.2082
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.005	0.2082	0.2082
Brugia malayi	neuropeptide F receptor	0.005	0.2082	0.2082
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.005	0.2082	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0976	0.0976
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.005	0.2082	0.2082
Schistosoma mansoni	biogenic amine (5HT) receptor	0.005	0.2082	0.2082
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0042	0.1643	0.1643

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	> 242 uM	Cytotoxicity against human MT4 cells by MTT assay	ChEMBL.	18692274

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL475427

Bibliographic References

No literature references available for this target.

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Detailed information for compound 977842