Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Brucella suis biovar 1 (strain 1330) | Histidinol dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | Get druggable targets OG5_129099 | All targets in OG5_129099 |
Mycobacterium ulcerans | histidinol dehydrogenase | Get druggable targets OG5_129099 | All targets in OG5_129099 |
Candida albicans | Phosphoribosyl-AMP cyclohydrolase | Get druggable targets OG5_129099 | All targets in OG5_129099 |
Candida albicans | Phosphoribosyl-AMP cyclohydrolase | Get druggable targets OG5_129099 | All targets in OG5_129099 |
Mycobacterium leprae | Probable histidinol dehydrogenase HisD (HDH) | Get druggable targets OG5_129099 | All targets in OG5_129099 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0124 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0124 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0124 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0124 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0124 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0124 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0124 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0124 | 0.008 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0124 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0044 | 0.3523 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0124 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0124 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0124 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0124 | 1 |
Mycobacterium ulcerans | histidinol dehydrogenase | 0.0876 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0044 | 0.3523 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0124 | 0.5 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 0.0876 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0044 | 0.3523 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0124 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0124 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0124 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0124 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0124 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0124 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.