Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Candida albicans | Involved in protection against oxidative damage | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0156 | 0.2381 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0275 | 1 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0275 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0275 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0275 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 94 nM | inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 20299219 |
Kinact (binding) | = 5.2 10'6nM | Inhibition of human recombinant CA3 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 7 nM | Inhibition of human recombinant CA14 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 40.8 nM | Inhibition of human recombinant CA2 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 47 nM | Inhibition of mouse recombinant CA15 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 58 nM | Inhibition of human recombinant CA7 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 60 nM | Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 63 nM | Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 619 nM | Inhibition of human recombinant CA5A by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 659 nM | Inhibition of human recombinant CA1 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 672 nM | Inhibition of human recombinant CA5B by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 759 nM | Inhibition of mouse recombinant CA13 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 2912 nM | Inhibition of human recombinant CA4 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 4450 nM | Inhibition of human recombinant CA6 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.