Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | P38 map kinase family protein 2 | 0.0152 | 0.8755 | 0.836 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0162 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0162 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0162 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.8755 | 0.836 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0081 | 0 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0162 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0162 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0162 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.01 | 0.2407 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0082 | 0.0151 | 0.0151 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0162 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.8755 | 0.836 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.8755 | 0.4482 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0162 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.01 | 0.2407 | 0.2407 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0162 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0144 | 0.7743 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0162 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.8755 | 0.836 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.8755 | 0.836 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.8755 | 0.836 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0162 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0162 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0162 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0162 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0162 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0162 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0081 | 0 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0162 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.8755 | 0.836 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0162 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0144 | 0.7743 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 0.8755 | 0.836 |
Leishmania major | p450 reductase, putative | 0.0162 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0162 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2700 nM | Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human GST-tagged p38alpha by fluorescence polarisation assay | ChEMBL. | 18614366 |
Ki (binding) | = 430 nM | Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human GST-tagged p38alpha by fluorescence polarisation assay | ChEMBL. | 18614366 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.