TDR Targets

Basic information

Technical information

TDR Targets ID: 979406
Name: 1H-indol-2-yl-[4-(phenylmethyl)piperazin-1-yl ]methanone
MW: 319.4 | Formula: C20H21N3O
H donors: 1 H acceptors: 1 LogP: 3.15 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cc2c([nH]1)cccc2)N1CCN(CC1)Cc1ccccc1
InChi: 1S/C20H21N3O/c24-20(19-14-17-8-4-5-9-18(17)21-19)23-12-10-22(11-13-23)15-16-6-2-1-3-7-16/h1-9,14,21H,10-13,15H2
InChiKey: IKKXRHVVWDOOGY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1H-indol-2-yl-[4-(phenylmethyl)-1-piperazinyl]methanone
[4-(benzyl)piperazin-1-yl]-(1H-indol-2-yl)methanone
STOCK6S-27875

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0264	0.5496	1
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0161	0.311	0.5048
Schistosoma mansoni	kinase	0.0049	0.0519	0.0945
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.1615	0.2938
Brugia malayi	beta-lactamase family protein	0.0072	0.1049	0.1701
Loa Loa (eye worm)	hypothetical protein	0.005	0.0543	0.0881
Brugia malayi	beta-lactamase	0.0072	0.1049	0.1701
Echinococcus granulosus	transient receptor potential cation channel	0.0157	0.3016	0.414
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0419	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0293	0.6162	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0096	0.1615	0.2621
Onchocerca volvulus		0.005	0.0543	0.0988
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0419	0.0763
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0264	0.5496	0.7545
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0419	0.0763
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.1049	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0419	0.068
Leishmania major	eukaryotic initiation factor 4a, putative	0.0264	0.5496	1
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0264	0.5496	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.1615	0.1273
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1615	0.2247
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1615	0.2247
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0264	0.5496	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0419	0.0763
Brugia malayi	PAS domain containing protein	0.0052	0.059	0.0958
Echinococcus multilocularis	transfer RNA-Lys	0.0039	0.0278	0.0381
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0264	0.5496	1
Treponema pallidum	ATP-dependent RNA helicase	0.0264	0.5496	0.5
Onchocerca volvulus		0.0039	0.0278	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1049	0.1701
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1615	0.2247
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0096	0.1615	0.2217
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0419	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0175	0.3423	0.5555
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1049	0.1701
Brugia malayi	eukaryotic initiation factor 4A	0.0264	0.5496	0.8918
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0543	0.0988
Echinococcus multilocularis	ankyrin repeat protein	0.0154	0.2943	0.4041
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.1049	1
Echinococcus granulosus	muscleblind protein	0.0293	0.6162	0.8461
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1049	0.1701
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0264	0.5496	1
Echinococcus multilocularis	tumor protein p63	0.0342	0.7284	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.1049	0.1701
Loa Loa (eye worm)	hypothetical protein	0.0293	0.6162	1
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1615	0.2247
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1615	0.2247
Brugia malayi	bHLH-PAS transcription factor	0.0039	0.0278	0.0451
Schistosoma mansoni	single-minded	0.0052	0.059	0.1074
Brugia malayi	beta-lactamase family protein	0.0072	0.1049	0.1701
Mycobacterium ulcerans	lipase LipD	0.0072	0.1049	1
Echinococcus multilocularis	muscleblind protein 1	0.0293	0.6162	0.8461
Schistosoma mansoni	hypothetical protein	0.0171	0.3347	0.6091
Echinococcus granulosus	tumor protein p63	0.0342	0.7284	1
Onchocerca volvulus		0.0072	0.1049	0.1908
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1615	0.2247
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.1049	0.5
Mycobacterium ulcerans	hypothetical protein	0.0072	0.1049	1
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0264	0.5496	0.7545
Brugia malayi	serine/threonine-protein kinase plk-2	0.0096	0.1615	0.2621
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0264	0.5496	1
Schistosoma mansoni	hypothetical protein	0.0171	0.3347	0.6091
Onchocerca volvulus		0.0072	0.1049	0.1908
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.1049	0.1116
Echinococcus multilocularis	geminin	0.0171	0.3347	0.4596
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0419	0.068
Schistosoma mansoni	eyes absent homolog	0.0087	0.1396	0.2541
Loa Loa (eye worm)	hypothetical protein	0.0264	0.5496	0.8918
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0264	0.5496	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.1049	0.1116
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.1049	0.1701
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.1049	0.1116
Brugia malayi	hypoxia-induced factor 1	0.0161	0.311	0.5048
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0154	0.2943	0.5356
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1615	0.2247
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0264	0.5496	1
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0264	0.5496	1
Onchocerca volvulus		0.0072	0.1049	0.1908
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0096	0.1615	0.2217
Schistosoma mansoni	aryl hydrocarbon receptor	0.0052	0.059	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1396	0.2266
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0264	0.5496	0.4968
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1049	0.1701
Echinococcus granulosus	ankyrin repeat protein	0.0154	0.2943	0.4041
Trichomonas vaginalis	esterase, putative	0.0072	0.1049	0.1116
Trypanosoma brucei	polo-like protein kinase	0.0096	0.1615	0.1273
Loa Loa (eye worm)	beta-lactamase	0.0072	0.1049	0.1701
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0419	0.0575
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0264	0.5496	1
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0264	0.5496	0.7545
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.1615	0.1273
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.1049	0.144
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1049	0.1701
Plasmodium vivax	RNA helicase-1, putative	0.0264	0.5496	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.1049	0.1116
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0096	0.1615	0.1273
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1396	0.2266
Brugia malayi	Muscleblind-like protein	0.0293	0.6162	1
Brugia malayi	hypothetical protein	0.0175	0.3423	0.5555
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0264	0.5496	0.7545
Brugia malayi	hypothetical protein	0.0087	0.1396	0.2266
Echinococcus multilocularis	transient receptor potential cation channel	0.0157	0.3016	0.414
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.1049	0.1908
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0264	0.5496	1
Mycobacterium ulcerans	beta-lactamase	0.0072	0.1049	1
Echinococcus granulosus	geminin	0.0171	0.3347	0.4596
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.1049	0.1908
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0096	0.1615	0.2938
Leishmania major	eukaryotic initiation factor 4a, putative	0.0264	0.5496	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.1049	0.1116
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0419	0.0575
Echinococcus granulosus	single minded 2	0.0039	0.0278	0.0381
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0264	0.5496	1
Echinococcus multilocularis	muscleblind protein	0.0293	0.6162	0.8461
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.1049	0.144
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0264	0.5496	0.5
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1049	0.1701
Mycobacterium leprae	Probable lipase LipE	0.0072	0.1049	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 2 %	Antagonist activity at PAR1 expressed in CHO cells assessed as inhibition of SFLLR-NH2-induced calcium release at 10 uM by FLIPR assay	ChEMBL.	20137929

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL476624

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 979406