Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Metabotropic glutamate receptor 2 | 872 aa | 774 aa | 20.4 % | |
Schistosoma mansoni | metabotropic glutamate receptor | Metabotropic glutamate receptor 2 | 872 aa | 892 aa | 26.9 % |
Onchocerca volvulus | Golgi-associated plant pathogenesis-related protein 1 homolog | Metabotropic glutamate receptor 2 | 872 aa | 884 aa | 35.3 % |
Loa Loa (eye worm) | hypothetical protein | Metabotropic glutamate receptor 2 | 872 aa | 822 aa | 21.2 % |
Onchocerca volvulus | Cell death abnormality protein 8 homolog | Metabotropic glutamate receptor 2 | 872 aa | 883 aa | 43.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0724 | 0.0724 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0061 | 0.0524 | 0.0446 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0055 | 0.0443 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.4945 | 0.4945 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0439 | 0.5868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0069 | 0.0642 | 0.097 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0075 | 0.0724 | 0.062 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0439 | 0.5868 | 1 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0439 | 0.5868 | 0.5834 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0075 | 0.0724 | 0.062 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.0384 | 0.0523 |
Loa Loa (eye worm) | glutamate receptor | 0.0061 | 0.0524 | 0.0524 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0732 | 1 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0439 | 0.5868 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0439 | 0.5868 | 0.5868 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0732 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0732 | 1 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0439 | 0.5868 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 26 nM | Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamate | ChEMBL. | 18812259 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.