Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0219 | 0.4659 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0219 | 0.4659 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0219 | 0.4659 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0219 | 0.4659 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0219 | 0.4659 | 0.4659 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0219 | 0.4659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.4659 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0219 | 0.4659 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0219 | 0.4659 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0219 | 0.4659 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0219 | 0.4659 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.4659 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0219 | 0.4659 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.67 uM | Agonist activity at human PPARgamma expressed in african green monkey CV-1 co-transfected with GAL4 by by dual-glo luciferase reporter gene assay | ChEMBL. | 18771917 |
EC50 (functional) | = 3.24 uM | Agonist activity at human PPARalpha expressed in african green monkey CV-1 by co-transfected with GAL4 by by dual-glo luciferase reporter gene assay | ChEMBL. | 18771917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.