Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Homo sapiens | carboxylesterase 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Brugia malayi | Carboxylesterase family protein | carboxylesterase 1 | 567 aa | 532 aa | 24.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0173 | 0.9424 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.9424 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.9424 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 0.9424 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.9424 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.9424 | 1 |
Brugia malayi | Lipase family protein | 0.0173 | 0.9424 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.6346 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0182 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.6346 | 0.6733 |
Schistosoma mansoni | amidase | 0.0123 | 0.6346 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.6346 | 0.6733 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.6346 | 0.6733 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.6346 | 0.6733 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.9424 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.9424 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.9424 | 0.5 |
Brugia malayi | amidase | 0.0123 | 0.6346 | 0.6733 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.6346 | 0.6733 |
Loa Loa (eye worm) | lipase | 0.0173 | 0.9424 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.9424 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5 | Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes using para-nitrophenylbutyrate by colorimetric assay | ChEMBL. | 26584396 |
IC50 (binding) | = 0.1 uM | Inhibition of TGH | ChEMBL. | 18630870 |
IC50 (binding) | = 0.3 uM | Inhibition of rat FAAH expressed in Escherichia coli | ChEMBL. | 18630870 |
IC50 (binding) | > 100 uM | Inhibition of KIAA1363 hydrolase | ChEMBL. | 18630870 |
Ki (binding) | = 1.4 nM | Inhibition of rat FAAH expressed in Escherichia coli at pH 9.0 | ChEMBL. | 18630870 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.