Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0023 | 0.0536 | 0.0536 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0023 | 0.0536 | 0.0536 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0023 | 0.0536 | 0.0536 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0101 | 0.6229 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0081 | 0.478 | 0.478 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0023 | 0.0536 | 0.0536 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0023 | 0.0536 | 0.0536 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0077 | 0.4505 | 0.4505 |
Echinococcus granulosus | glutamate receptor 2 | 0.0023 | 0.0536 | 0.0536 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0077 | 0.4505 | 0.4505 |
Echinococcus multilocularis | glutamate receptor 2 | 0.002 | 0.0261 | 0.0261 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0023 | 0.0536 | 0.0536 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0081 | 0.478 | 0.478 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0023 | 0.0536 | 0.0536 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0085 | 0.5041 | 0.5041 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0023 | 0.0536 | 0.0536 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0023 | 0.0536 | 0.0536 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.002 | 0.0261 | 0.0261 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0085 | 0.5041 | 0.5041 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.002 | 0.0261 | 0.0261 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.005 uM | Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay | ChEMBL. | 21640588 |
IC50 (functional) | = 0.025 uM | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production treated 1 hr before LPS challenge measured after 18 hrs | ChEMBL. | 21640588 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21640588 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.