Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0135 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | potassium large conductance calcium activated | 0.0056 | 0.2958 | 0.2958 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0056 | 0.2958 | 0.2958 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0135 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.0052 | 0.2609 | 0.2609 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0135 | 1 | 1 |
Echinococcus granulosus | calcium activated potassium channel variant | 0.0052 | 0.2609 | 0.2609 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0052 | 0.2609 | 0.2609 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | MaxiK calcium-activated potassium channel | 0.0037 | 0.1282 | 0.1282 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1282 | 0.1282 |
Echinococcus multilocularis | calcium activated potassium channel variant | 0.0052 | 0.2609 | 0.2609 |
Echinococcus multilocularis | acetylcholinesterase | 0.0135 | 1 | 1 |
Brugia malayi | Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog | 0.0037 | 0.1282 | 0.1282 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0135 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0135 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0135 | 1 | 1 |
Echinococcus granulosus | calcium activated potassium channel | 0.0056 | 0.2958 | 0.2958 |
Echinococcus multilocularis | acetylcholinesterase | 0.0135 | 1 | 1 |
Echinococcus multilocularis | potassium large conductance calcium activated | 0.0056 | 0.2958 | 0.2958 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Schistosoma mansoni | calcium-activated potassium channel | 0.0056 | 0.2958 | 0.2958 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.06 | Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone | ChEMBL. | 19026552 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.