Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.061 | 0.1071 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0888 | 0.3366 | 0.3366 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Leishmania major | cathepsin L-like protease | 0.0888 | 0.3366 | 1 |
Onchocerca volvulus | 0.0888 | 0.3366 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0662 | 0.1508 | 0.4479 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0888 | 0.3366 | 0.257 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Onchocerca volvulus | 0.0888 | 0.3366 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0888 | 0.3366 | 0.3366 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Onchocerca volvulus | 0.0888 | 0.3366 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0888 | 0.3366 | 0.3366 |
Leishmania major | cathepsin L-like protease | 0.0888 | 0.3366 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0888 | 0.3366 | 0.3366 |
Loa Loa (eye worm) | cathepsin B | 0.0662 | 0.1508 | 0.0489 |
Leishmania major | cathepsin L-like protease | 0.0888 | 0.3366 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0888 | 0.3366 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.061 | 0.1071 | 0.1071 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0888 | 0.3366 | 0.3366 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0888 | 0.3366 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.061 | 0.1071 | 0.1071 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0888 | 0.3366 | 0.3366 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Leishmania major | cathepsin L-like protease | 0.0888 | 0.3366 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0888 | 0.3366 | 0.3366 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0888 | 0.3366 | 0.257 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.061 | 0.1071 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.0888 | 0.3366 | 1 |
Onchocerca volvulus | 0.0888 | 0.3366 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0888 | 0.3366 | 0.3366 |
Leishmania major | cathepsin L-like protease | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1692 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0662 | 0.1508 | 0.5 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0888 | 0.3366 | 0.3366 |
Loa Loa (eye worm) | cysteine protease | 0.0888 | 0.3366 | 0.257 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0888 | 0.3366 | 0.3366 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0888 | 0.3366 | 0.3366 |
Plasmodium vivax | vivapain-2 | 0.0888 | 0.3366 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0888 | 0.3366 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0888 | 0.3366 | 0.3366 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Leishmania major | cathepsin L-like protease | 0.0888 | 0.3366 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.061 | 0.1071 | 0.1071 |
Onchocerca volvulus | 0.0888 | 0.3366 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.061 | 0.1071 | 0.1071 |
Brugia malayi | Cathepsin L-like precursor | 0.0888 | 0.3366 | 0.3366 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.061 | 0.1071 | 0.1071 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1692 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0662 | 0.1508 | 0.4479 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0888 | 0.3366 | 0.3366 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0888 | 0.3366 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0888 | 0.3366 | 0.3366 |
Onchocerca volvulus | 0.0888 | 0.3366 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.061 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | ctsf protein | 0.0888 | 0.3366 | 0.257 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1692 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1692 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1692 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0888 | 0.3366 | 1 |
Echinococcus granulosus | cathepsin b | 0.1692 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Echinococcus granulosus | cathepsin b | 0.1692 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1692 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0888 | 0.3366 | 0.3366 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0888 | 0.3366 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1692 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0888 | 0.3366 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0888 | 0.3366 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0888 | 0.3366 | 0.3366 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.061 | 0.1071 | 0.1071 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Onchocerca volvulus | 0.0888 | 0.3366 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1692 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0662 | 0.1508 | 0.1508 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0888 | 0.3366 | 0.257 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0888 | 0.3366 | 0.3366 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0662 | 0.1508 | 0.1508 |
Loa Loa (eye worm) | hypothetical protein | 0.0888 | 0.3366 | 0.257 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.061 | 0.1071 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0888 | 0.3366 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0888 | 0.3366 | 0.3366 |
Leishmania major | cathepsin L-like protease | 0.0888 | 0.3366 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0888 | 0.3366 | 0.3366 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0888 | 0.3366 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0888 | 0.3366 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0888 | 0.3366 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0888 | 0.3366 | 0.3366 |
Giardia lamblia | Cathepsin B precursor | 0.0662 | 0.1508 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0888 | 0.3366 | 0.3366 |
Giardia lamblia | Cathepsin B precursor | 0.0662 | 0.1508 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0888 | 0.3366 | 0.3366 |
Leishmania major | cathepsin L-like protease | 0.0888 | 0.3366 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 28.7 uM | Inhibition of human liver microsome CYP3A4 in assessed as [14C]formaldehyde formation | ChEMBL. | 15679319 |
IC50 (ADMET) | > 100 uM | Inhibition of human liver microsome CYP2D6 in assessed as [14C]formaldehyde formation | ChEMBL. | 15679319 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.