Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GPI-anchor transamidase | 0.0214 | 0.1982 | 0.1961 |
Trypanosoma brucei | GPI-anchor transamidase subunit 8 (GPI8) | 0.0214 | 0.1982 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0921 | 1 | 1 |
Plasmodium falciparum | GPI-anchor transamidase, putative | 0.0214 | 0.1982 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0921 | 1 | 1 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.0921 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.1982 | 0.1941 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0921 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0052 | 0.0026 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0921 | 1 | 1 |
Echinococcus granulosus | GPI anchor transamidase | 0.0214 | 0.1982 | 0.2242 |
Schistosoma mansoni | hypothetical protein | 0.0707 | 0.7577 | 0.7571 |
Brugia malayi | Inositol-1 | 0.0043 | 0.0052 | 0.0026 |
Loa Loa (eye worm) | peptidase C13 family protein | 0.0921 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.115 | 0.1104 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0214 | 0.1982 | 0.1941 |
Entamoeba histolytica | GPI-anchor transamidase, putative | 0.0214 | 0.1982 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0214 | 0.1982 | 0.1941 |
Echinococcus multilocularis | GPI anchor transamidase | 0.0214 | 0.1982 | 0.2242 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.115 | 0.1127 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0043 | 0.0052 | 0.5 |
Leishmania major | GPI-anchor transamidase subunit 8 (GPI8), putative | 0.0214 | 0.1982 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0921 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.081 | 0.8751 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0921 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0052 | 0.0026 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.0921 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0921 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.0052 | 0.0029 |
Plasmodium vivax | GPI-anchor transamidase, putative | 0.0214 | 0.1982 | 0.5 |
Giardia lamblia | GPI-anchor transamidase, putative | 0.0214 | 0.1982 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0214 | 0.1982 | 0.1941 |
Schistosoma mansoni | microtubule-associated protein tau | 0.081 | 0.8751 | 0.8748 |
Schistosoma mansoni | glycosylphosphatidylinositol:protein transamidase (C13 family) | 0.0214 | 0.1982 | 0.1961 |
Schistosoma mansoni | family C13 non-peptidase homologue (C13 family) | 0.0921 | 1 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.081 | 0.8751 | 1 |
Toxoplasma gondii | peptidase c13 family protein | 0.0214 | 0.1982 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.0052 | 0.0029 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.0052 | 0.0131 |
Trypanosoma cruzi | cysteine peptidase, Clan CD, family C13, putative | 0.0214 | 0.1982 | 1 |
Onchocerca volvulus | Legumain homolog | 0.0921 | 1 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.115 | 0.1104 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.0052 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1.34 10'-5M | Growth inhibition of human A549 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
GI50 (functional) | > 100 mM | Growth inhibition of human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
GI50 (functional) | > 100 mM | Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
LC50 (functional) | > 2.34 10'-5M | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
LC50 (functional) | > 100 mM | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
LC50 (functional) | > 100 mM | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
TGI (functional) | > 2.34 10'-5M | Growth inhibition of human A549 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
TGI (functional) | > 100 mM | Growth inhibition of human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
TGI (functional) | > 100 mM | Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.