Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.012 | 0.562 | 0.562 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0102 | 0.383 | 0.6541 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.383 | 0.6816 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.012 | 0.562 | 0.562 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1788 | 0.1405 |
Plasmodium vivax | vivapain-2 | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1788 | 0.3182 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.012 | 0.562 | 0.5415 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0163 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.012 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0163 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.012 | 0.562 | 1 |
Plasmodium vivax | vivapain-2 | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.012 | 0.562 | 0.562 |
Onchocerca volvulus | Cathepsin L homolog | 0.012 | 0.562 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.012 | 0.562 | 0.5415 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0102 | 0.383 | 0.6816 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.012 | 0.562 | 0.5415 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.012 | 0.562 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0102 | 0.383 | 0.6816 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0082 | 0.1788 | 0.1788 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0163 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0082 | 0.1788 | 0.1788 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.383 | 0.383 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.383 | 0.6816 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.383 | 0.6816 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0102 | 0.383 | 0.383 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.012 | 0.562 | 0.562 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.012 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0068 | 0.0446 | 0.0446 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.012 | 0.562 | 0.5415 |
Echinococcus multilocularis | cathepsin b | 0.0163 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0082 | 0.1788 | 0.1788 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1788 | 0.1405 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.383 | 0.383 |
Echinococcus granulosus | cathepsin b | 0.0163 | 1 | 1 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.562 | 0.5415 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0102 | 0.383 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.012 | 0.562 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1788 | 0.1405 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.383 | 0.6541 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0068 | 0.0446 | 0.0446 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Leishmania major | cysteine peptidase A (CPA) | 0.012 | 0.562 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0102 | 0.383 | 0.383 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.012 | 0.562 | 0.562 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1788 | 0.3182 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.383 | 0.383 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0082 | 0.1788 | 0.1788 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0082 | 0.1788 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0102 | 0.383 | 0.6816 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.383 | 0.383 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.012 | 0.562 | 0.562 |
Brugia malayi | cathepsin L-like precursor | 0.0082 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.383 | 0.6541 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.383 | 0.6816 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.012 | 0.562 | 0.562 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.012 | 0.562 | 0.5415 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0102 | 0.383 | 0.533 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0068 | 0.0446 | 0.0794 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0082 | 0.1788 | 0.1788 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.383 | 0.3542 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0102 | 0.383 | 0.383 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0102 | 0.383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Entamoeba histolytica | cysteine protease, putative | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0102 | 0.383 | 0.383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0068 | 0.0446 | 0.0794 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0102 | 0.383 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.012 | 0.562 | 0.562 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0102 | 0.383 | 0.383 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.012 | 0.562 | 0.562 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.012 | 0.562 | 0.562 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0082 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at human FPR2 expressed in RBL-2H3 cells assessed as induction of calcium mobilization | ChEMBL. | 20870313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.