Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.0042 | 0.0086 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0227 | 0.0366 |
Trypanosoma cruzi | kinesin, putative | 0.0043 | 0.0078 | 0.0059 |
Echinococcus granulosus | calpain A | 0.0061 | 0.0227 | 0.0322 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0227 | 0.0366 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.064 | 0.4902 | 1 |
Onchocerca volvulus | 0.0258 | 0.1815 | 0.3513 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0124 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0124 | 0.0254 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.064 | 0.4902 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0044 | 0.0088 | 0.0081 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.064 | 0.4902 | 0.4902 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0318 | 0.2303 | 0.4145 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0104 | 0.0572 | 0.0919 |
Echinococcus granulosus | cathepsin b | 0.0274 | 0.1946 | 0.3305 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0051 | 0.0144 | 0.0194 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.009 | 0.0462 | 0.0851 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.064 | 0.4902 | 0.8437 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0274 | 0.1946 | 0.1946 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0751 | 0.5803 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.009 | 0.0462 | 0.0851 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.064 | 0.4902 | 0.8437 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0318 | 0.2303 | 0.4643 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0318 | 0.2303 | 0.4643 |
Trypanosoma cruzi | kinesin, putative | 0.0043 | 0.0078 | 0.0059 |
Loa Loa (eye worm) | cathepsin B | 0.009 | 0.0462 | 0.0943 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0177 | 0.1165 | 0.1949 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0051 | 0.0144 | 0.0293 |
Brugia malayi | calpain 7 | 0.0061 | 0.0227 | 0.0464 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0177 | 0.1165 | 0.2376 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.009 | 0.0462 | 0.0851 |
Brugia malayi | eukaryotic initiation factor 4A | 0.064 | 0.4902 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0274 | 0.1946 | 0.3305 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0318 | 0.2303 | 0.4643 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.064 | 0.4902 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0044 | 0.0088 | 0.0081 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.064 | 0.4902 | 1 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0061 | 0.0227 | 0.0366 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.0061 | 0.0227 | 0.0227 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0061 | 0.0227 | 0.0366 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0051 | 0.0144 | 0.0194 |
Loa Loa (eye worm) | calpain 5 | 0.0043 | 0.0078 | 0.016 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.064 | 0.4902 | 1 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0177 | 0.1158 | 0.1938 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.064 | 0.4902 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0751 | 0.5803 | 0.5803 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0318 | 0.2303 | 0.4643 |
Echinococcus granulosus | calpain | 0.0061 | 0.0227 | 0.0322 |
Trypanosoma brucei | calpain-like protein, putative | 0.0061 | 0.0227 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0144 | 0.0293 |
Schistosoma mansoni | calpain (C02 family) | 0.0061 | 0.0227 | 0.0227 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0051 | 0.0144 | 0.0293 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0163 | 0.1046 | 0.1046 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0699 | 0.1426 |
Echinococcus multilocularis | calpain family protein 1, d | 0.012 | 0.0699 | 0.1141 |
Trypanosoma brucei | calpain-like protein, putative | 0.0061 | 0.0227 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1946 | 0.397 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.055 | 0.1122 |
Trypanosoma brucei | calpain-like protein, putative | 0.0061 | 0.0227 | 0.0366 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.005 | 0.0101 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0318 | 0.2303 | 0.4643 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0227 | 0.0366 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.064 | 0.4902 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.064 | 0.4902 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0274 | 0.1946 | 0.1946 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Echinococcus multilocularis | cathepsin b | 0.0274 | 0.1946 | 0.3305 |
Brugia malayi | calpain family protein 1 | 0.0163 | 0.1046 | 0.2133 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0051 | 0.0144 | 0.0194 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0751 | 0.5803 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0177 | 0.1158 | 0.1158 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0274 | 0.1946 | 0.397 |
Leishmania major | kinesin, putative | 0.0043 | 0.0078 | 0.0059 |
Brugia malayi | Pepsin A precursor | 0.0051 | 0.0144 | 0.0293 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.064 | 0.4902 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0274 | 0.1946 | 0.1946 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.064 | 0.4902 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0163 | 0.1046 | 0.2133 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1046 | 0.2133 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0177 | 0.1165 | 0.2376 |
Echinococcus granulosus | calpain A | 0.0177 | 0.1162 | 0.1944 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0177 | 0.1165 | 0.1949 |
Brugia malayi | calpain family protein 1 | 0.0163 | 0.1046 | 0.2133 |
Schistosoma mansoni | calpain C (C02 family) | 0.0061 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.005 | 0.0101 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0051 | 0.0144 | 0.0194 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.064 | 0.4902 | 0.8437 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Echinococcus granulosus | calpain 5 | 0.0061 | 0.0227 | 0.0322 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0155 | 0.0988 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0177 | 0.1165 | 0.1949 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0274 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0144 | 0.0293 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0227 | 0.0366 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0318 | 0.2303 | 0.4643 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0144 | 0.0293 |
Onchocerca volvulus | 0.0101 | 0.055 | 0.0854 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0227 | 0.1562 | 0.3187 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Trypanosoma brucei | calpain-like protein, putative | 0.0061 | 0.0227 | 0.0366 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.064 | 0.4902 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.064 | 0.4902 | 0.4902 |
Trypanosoma brucei | antigen, putative | 0.0061 | 0.0227 | 0.0366 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0066 | 0.0261 | 0.0533 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0124 | 0.0254 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0051 | 0.0144 | 0.0293 |
Echinococcus multilocularis | calpain | 0.0061 | 0.0227 | 0.0322 |
Brugia malayi | jmjC domain containing protein | 0.0104 | 0.0572 | 0.1166 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0274 | 0.1946 | 0.3908 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.0965 | 0.0965 |
Loa Loa (eye worm) | calpain family protein 1 | 0.012 | 0.0699 | 0.1426 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0227 | 0.0366 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0051 | 0.0144 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0171 | 0.0349 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0155 | 0.0988 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0318 | 0.2303 | 0.4643 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0144 | 0.0293 |
Entamoeba histolytica | calpain large subunit domain III containing protein | 0.0043 | 0.0078 | 0.0059 |
Schistosoma mansoni | jumonji domain containing protein | 0.0083 | 0.0399 | 0.0399 |
Brugia malayi | calpain 5 | 0.0043 | 0.0078 | 0.016 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0318 | 0.2303 | 0.4643 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0227 | 0.0366 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0227 | 0.0366 |
Trichomonas vaginalis | set domain proteins, putative | 0.0258 | 0.1815 | 0.3639 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.064 | 0.4902 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0051 | 0.0144 | 0.0177 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.0965 | 0.0965 |
Entamoeba histolytica | protein kinase, putative | 0.0043 | 0.0078 | 0.0059 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0177 | 0.1158 | 0.1158 |
Echinococcus multilocularis | calpain A | 0.0177 | 0.1162 | 0.1944 |
Toxoplasma gondii | cathepsin B | 0.009 | 0.0462 | 0.0851 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.064 | 0.4902 | 0.8437 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0061 | 0.0227 | 0.0366 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0039 | 0.005 | 0.0013 |
Onchocerca volvulus | 0.0103 | 0.056 | 0.0876 | |
Loa Loa (eye worm) | calpain | 0.0061 | 0.0227 | 0.0464 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.0061 | 0.0227 | 0.0227 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0061 | 0.0227 | 0.0366 |
Treponema pallidum | ATP-dependent RNA helicase | 0.064 | 0.4902 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.064 | 0.4902 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0318 | 0.2303 | 0.4643 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0061 | 0.0227 | 0.0366 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0177 | 0.1158 | 0.1938 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0039 | 0.005 | 0.0013 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.0042 | 0.0086 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0144 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0897 | 0.1829 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0042 | 0.0042 |
Echinococcus multilocularis | hypothetical protein | 0.0061 | 0.0227 | 0.0322 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0051 | 0.0144 | 0.0293 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0104 | 0.0572 | 0.0919 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0124 | 0.0254 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0051 | 0.0144 | 0.0293 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.064 | 0.4902 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.009 | 0.0462 | 0.0851 |
Brugia malayi | Pre-SET motif family protein | 0.0227 | 0.1562 | 0.3187 |
Echinococcus granulosus | calpain 7 C02 family | 0.0061 | 0.0227 | 0.0322 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0051 | 0.0144 | 0.0144 |
Echinococcus multilocularis | calpain 7 (C02 family) | 0.0061 | 0.0227 | 0.0322 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0318 | 0.2303 | 0.4643 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0051 | 0.0144 | 0.0194 |
Schistosoma mansoni | Mername-AA248 (C02 family) | 0.0061 | 0.0227 | 0.0227 |
Toxoplasma gondii | aspartyl protease | 0.0051 | 0.0144 | 0.0194 |
Plasmodium vivax | RNA helicase-1, putative | 0.064 | 0.4902 | 1 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0051 | 0.0144 | 0.0293 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0061 | 0.0227 | 0.0366 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0061 | 0.0227 | 0.0366 |
Echinococcus granulosus | cathepsin b | 0.0274 | 0.1946 | 0.3305 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0061 | 0.0227 | 0.0366 |
Trypanosoma brucei | kinesin, putative | 0.0043 | 0.0078 | 0.0059 |
Plasmodium vivax | calpain, putative | 0.0061 | 0.0227 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.4902 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.005 | 0.005 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.009 | 0.0462 | 0.0462 |
Echinococcus multilocularis | calpain 5 | 0.0061 | 0.0227 | 0.0322 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 11.3 % | Inhibition of human recombinant SIRT1 expressed in Escherichia coli at 50 uM incubated at 37 degC for 2 hrs by Fluor de Lys fluorescence assay | ChEMBL. | 21306905 |
Inhibition (binding) | = 81.2 % | Inhibition of human recombinant SIRT2 expressed in Escherichia coli at 50 uM incubated at 37 degC for 2 hrs by Fluor de Lys fluorescence assay | ChEMBL. | 21306905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.