Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fibroinase | 0.012 | 0.562 | 0.5415 |
Echinococcus multilocularis | cathepsin b | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.01 | 0.37 | 0.6584 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0163 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0081 | 0.1788 | 0.1788 |
Plasmodium vivax | RNA helicase-1, putative | 0.01 | 0.37 | 0.6584 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.012 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Echinococcus multilocularis | cysteine protease | 0.012 | 0.562 | 0.562 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.012 | 0.562 | 0.5415 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.012 | 0.562 | 0.5415 |
Onchocerca volvulus | Cathepsin L homolog | 0.012 | 0.562 | 1 |
Plasmodium vivax | vivapain-2 | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.012 | 0.562 | 0.562 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0163 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Plasmodium vivax | vivapain-2 | 0.012 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1788 | 0.1405 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.012 | 0.562 | 0.562 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.1788 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.01 | 0.37 | 0.6584 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.01 | 0.37 | 0.629 |
Echinococcus granulosus | cathepsin b | 0.0163 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.01 | 0.37 | 0.37 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1788 | 0.1405 |
Brugia malayi | Cathepsin L-like precursor | 0.0081 | 0.1788 | 0.1788 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Treponema pallidum | ATP-dependent RNA helicase | 0.01 | 0.37 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.562 | 0.5415 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.012 | 0.562 | 0.562 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.012 | 0.562 | 0.5415 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0068 | 0.0446 | 0.0446 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.012 | 0.562 | 0.562 |
Brugia malayi | eukaryotic initiation factor 4A | 0.01 | 0.37 | 0.37 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.01 | 0.37 | 0.6584 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.01 | 0.37 | 0.37 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0081 | 0.1788 | 0.1788 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.01 | 0.37 | 0.6584 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Brugia malayi | cathepsin L-like precursor | 0.0081 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.01 | 0.37 | 0.37 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.01 | 0.37 | 0.6584 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.012 | 0.562 | 0.562 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0081 | 0.1788 | 0.3182 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0081 | 0.1788 | 0.1788 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.01 | 0.37 | 0.37 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.1788 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0068 | 0.0446 | 0.0446 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.01 | 0.37 | 0.37 |
Leishmania major | cysteine peptidase A (CPA) | 0.012 | 0.562 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.01 | 0.37 | 0.629 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1788 | 0.1405 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.012 | 0.562 | 0.562 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.01 | 0.37 | 0.37 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0081 | 0.1788 | 0.1788 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.012 | 0.562 | 0.562 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.01 | 0.37 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.01 | 0.37 | 0.37 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.37 | 0.3406 |
Brugia malayi | Cathepsin L-like precursor | 0.0081 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0068 | 0.0446 | 0.0794 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.01 | 0.37 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.012 | 0.562 | 0.562 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.01 | 0.37 | 0.37 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0068 | 0.0446 | 0.0794 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.01 | 0.37 | 0.4991 |
Brugia malayi | Papain family cysteine protease containing protein | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.01 | 0.37 | 0.6584 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.012 | 0.562 | 0.562 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.01 | 0.37 | 0.629 |
Entamoeba histolytica | cysteine proteinase, putative | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.012 | 0.562 | 0.5415 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 29 mm | Antimicrobial activity against Escherichia coli after 24 hrs by well diffusion method | ChEMBL. | 18930654 |
MIC (functional) | > 6.25 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay | ChEMBL. | 18930654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.