Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0694259 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0694259 | 1 | 1 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0694259 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00666754 | 0.074657 | 0.074657 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0694259 | 1 | 1 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.00160418 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.00781995 | 0.0916487 | 0.0916487 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0694259 | 1 | 1 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.00160418 | 0 | 0.5 |
Onchocerca volvulus | 0.0694259 | 1 | 0.5 | |
Loa Loa (eye worm) | CMGC/CDK/CDK9 protein kinase | 0.00666754 | 0.074657 | 0.074657 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.00160418 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.00666754 | 0.074657 | 0.074657 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.00666754 | 0.074657 | 0.074657 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.00160418 | 0 | 0.5 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0694259 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.00666754 | 0.074657 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0694259 | 1 | 1 |
Brugia malayi | cyclin-dependent kinase 9 | 0.00666754 | 0.074657 | 0.074657 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.00160418 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0694259 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.00781995 | 0.0916487 | 0.0916487 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.00160418 | 0 | 0.5 |
Plasmodium falciparum | MO15-related protein kinase | 0.00160418 | 0 | 0.5 |
Onchocerca volvulus | 0.0694259 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0347157 | 0.488215 | 0.488215 |
Trypanosoma brucei | protein kinase, putative | 0.00160418 | 0 | 0.5 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.00160418 | 0 | 0.5 |
Schistosoma mansoni | kinase | 0.00666754 | 0.074657 | 0.074657 |
Giardia lamblia | Kinase, CDC7 | 0.0694259 | 1 | 1 |
Trypanosoma brucei | Mitogen-activated protein kinase 10, putative | 0.00160418 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 24 ng/ml | Antimalarial activity after 48 hrs against Plasmodium falciparum NF54 infected human erythrocytes by [3H]hypoxanthine uptake | ChEMBL. | 11076547 |
IC50 (functional) | = 0.164 ug ml-1 | Antimalarial activity against Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake | ChEMBL. | 12193010 |
IC50 (functional) | > 1.87 ug ml-1 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by alamar blue assay | ChEMBL. | 12193010 |
IC50 (functional) | = 14.5 ug ml-1 | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen strain C2C4 containing galactosidase gene in rat L6 cells after 4 days | ChEMBL. | 12193010 |
IC50 (functional) | = 25.1 ug ml-1 | Antileishmanial activity against Leishmania donovani | ChEMBL. | 12193010 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 12193010 | ||
Plasmodium falciparum | ChEMBL23 | 11076547 | |
Trypanosoma cruzi | ChEMBL23 | 12193010 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.