Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.015 | 0.3756 | 0.3767 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0332 | 0.997 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.015 | 0.3756 | 0.3767 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.004 | 0 | 0.5 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.015 | 0.3756 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0332 | 0.997 | 1 |
Loa Loa (eye worm) | lipase | 0.015 | 0.3756 | 0.3767 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0332 | 0.997 | 1 |
Leishmania major | hypothetical protein, conserved | 0.015 | 0.3756 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0332 | 0.997 | 1 |
Brugia malayi | Lipase family protein | 0.015 | 0.3756 | 0.3767 |
Trichomonas vaginalis | lipase containing protein, putative | 0.015 | 0.3756 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.997 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.004 | 0 | 0.5 |
Schistosoma mansoni | amidase | 0.0332 | 0.997 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.015 | 0.3756 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.015 | 0.3756 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0333 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.015 | 0.3756 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.004 | 0 | 0.5 |
Brugia malayi | amidase | 0.0332 | 0.997 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.015 | 0.3756 | 0.5 | |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.004 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.015 | 0.3756 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0332 | 0.997 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.98 nM | Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometry | ChEMBL. | 18954042 |
IC50 (binding) | = 954 nM | Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHOK1 cells by liquid scintillation spectrometry | ChEMBL. | 18954042 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.