Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor; Grin1/Grin2b | References | |
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Schistosoma mansoni | glutamate receptor NMDA | Glutamate NMDA receptor; Grin1/Grin2b | 938 aa | 933 aa | 39.1 % |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glutamate receptor 2 precursor | 0.0018 | 0.0122 | 0.0613 |
Echinococcus granulosus | glutamate receptor 2 | 0.0027 | 0.0765 | 0.0651 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0212 | 0.0124 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0027 | 0.0765 | 0.0651 |
Chlamydia trachomatis | glutamine binding protein | 0.0046 | 0.2083 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0046 | 0.2083 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0027 | 0.0765 | 0.0651 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0018 | 0.0122 | 0.0613 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0027 | 0.0765 | 0.0651 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0212 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1983 | 0.1884 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0027 | 0.0765 | 0.0651 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0064 | 0.3338 | 0.3256 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1983 | 0.1884 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0046 | 0.2083 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0738 | 0.3723 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0212 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0027 | 0.0765 | 0.0651 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0212 | 0.1071 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1778 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0212 | 0.0092 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0212 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0104 | 0.6172 | 0.6125 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0018 | 0.0122 | 0.0613 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0027 | 0.0765 | 0.0651 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0212 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0212 | 0.1019 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1571 | 0.7925 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0027 | 0.0765 | 0.0651 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0212 | 0.1071 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1778 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0738 | 0.3723 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0159 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0212 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0027 | 0.0765 | 0.0651 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0212 | 0.0092 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0046 | 0.2083 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0212 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1983 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0212 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0212 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0212 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.5529 | 0.5474 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1983 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0212 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0027 | 0.0765 | 0.0651 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0212 | 0.0124 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0046 | 0.2083 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0046 | 0.2083 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2269 | 0.294 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2269 | 0.294 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0018 | 0.0122 | 0.0613 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0122 | 0.7427 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0104 | 0.6172 | 0.6125 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.5529 | 0.5474 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.068 uM | Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method | ChEMBL. | 18800760 |
IC50 (binding) | = 1.91 uM | Displacement of [3H]astemizole from human ERG expressed in HEK293 cells | ChEMBL. | 18800760 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.