Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2079 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0 | 0.000002044 | 0.000002044 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0 | 0.000002044 | 0.000002044 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0009 | 0.0467 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0083 | 0.4689 | 0.4689 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0097 | 0.5486 | 0.5486 |
Echinococcus multilocularis | kelch protein 3 | 0 | 0.000002044 | 0.000002044 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0083 | 0.4689 | 0.4689 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0467 | 0.0467 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0467 | 0.0467 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0083 | 0.4689 | 0.4689 |
Echinococcus granulosus | kelch protein 3 | 0 | 0.000002044 | 0.000002044 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0097 | 0.5502 | 0.5502 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.4689 | 0.4689 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0467 | 0.0467 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0097 | 0.5486 | 0.5486 |
Echinococcus multilocularis | ferritin | 0.0009 | 0.0467 | 0.0467 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2079 | 0.5 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0467 | 0.0467 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0467 | 0.0467 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0176 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0176 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0083 | 0.4689 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0009 | 0.0467 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0083 | 0.4689 | 0.4689 |
Echinococcus multilocularis | carbonic anhydrase | 0.0083 | 0.4689 | 0.4689 |
Echinococcus granulosus | kelch protein 18 | 0 | 0.000002044 | 0.000002044 |
Brugia malayi | hypothetical protein | 0.0037 | 0.2079 | 0.2079 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.4689 | 0.4689 |
Plasmodium falciparum | carbonic anhydrase | 0.0083 | 0.4689 | 0.5 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0009 | 0.0467 | 0.5 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0467 | 0.0467 |
Echinococcus granulosus | ferritin | 0.0009 | 0.0467 | 0.0467 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.2079 | 0.2079 |
Schistosoma mansoni | carbonic anhydrase | 0.0083 | 0.4689 | 0.4689 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0176 | 1 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.2079 | 0.2079 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0009 | 0.0467 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0083 | 0.4689 | 0.4689 |
Leishmania major | carbonic anhydrase-like protein | 0.0176 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0083 | 0.4689 | 0.4689 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.5502 | 0.5502 |
Schistosoma mansoni | hypothetical protein | 0 | 0.000002044 | 0.000002044 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0083 | 0.4689 | 0.4689 |
Schistosoma mansoni | hypothetical protein | 0 | 0.000002044 | 0.000002044 |
Echinococcus granulosus | carbonic anhydrase | 0.0083 | 0.4689 | 0.4689 |
Echinococcus granulosus | kelch protein 12 | 0 | 0.000002044 | 0.000002044 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2079 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0083 | 0.4689 | 0.4689 |
Echinococcus multilocularis | expressed protein | 0.0009 | 0.0467 | 0.0467 |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0 | 0.000002044 | 0.000002044 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.2079 | 0.2079 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0083 | 0.4689 | 0.4689 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0176 | 1 | 1 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0.0467 | 0.5 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0097 | 0.5486 | 0.5486 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0009 | 0.0467 | 0.5 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0009 | 0.0467 | 0.5 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0097 | 0.5486 | 0.5486 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0176 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0083 | 0.4689 | 0.4689 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0097 | 0.5486 | 0.5486 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0176 | 1 | 1 |
Echinococcus granulosus | expressed protein | 0.0009 | 0.0467 | 0.0467 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0009 | 0.0467 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0176 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0176 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0 | 0.000002044 | 0.000002044 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0083 | 0.4689 | 0.4689 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0467 | 0.0467 |
Echinococcus multilocularis | kelch protein 12 | 0 | 0.000002044 | 0.000002044 |
Echinococcus multilocularis | kelch protein 18 | 0 | 0.000002044 | 0.000002044 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.2079 | 0.2079 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.4689 | 0.4689 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0083 | 0.4689 | 0.4689 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2079 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.4689 | 0.4689 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0176 | 1 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0467 | 0.0467 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0083 | 0.4689 | 0.4689 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 5.62 % | Displacement of [125I]iodocyanopindolol from human adrenergic beta-3 receptor at 1 uM | ChEMBL. | 19081260 |
Inhibition (binding) | = 16.18 % | Displacement of [125I]iodocyanopindolol from human adrenergic beta-3 receptor at 10 uM | ChEMBL. | 19081260 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.