Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Echinococcus granulosus | biogenic amine 5HT receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | zinc metalloprotease | 0.0092 | 0.0192 | 0.5 |
Toxoplasma gondii | peptidase family M13 protein | 0.0092 | 0.0192 | 0.5 |
Brugia malayi | hypothetical protein | 0.031 | 0.1114 | 0.094 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0092 | 0.0192 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0098 | 0.0007 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0675 | 0.2653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0098 | 0.0007 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0675 | 0.2653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0098 | 0.0007 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.2417 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0192 | 0.0102 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0098 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0192 | 0.0102 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0457 | 0.1734 | 0.6536 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0675 | 0.2653 | 0.2586 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0675 | 0.2653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0192 | 0.0102 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0457 | 0.1734 | 0.6265 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0098 | 0.0007 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0457 | 0.1734 | 0.6265 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0092 | 0.0192 | 0.0724 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0092 | 0.0192 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0098 | 0.0007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 223 nM | Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane | ChEMBL. | 18456500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.