Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0776 | 0.9606 |
Echinococcus multilocularis | geminin | 0.0198 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0281 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0808 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0023 | 0.034 | 1 |
Onchocerca volvulus | 0.0031 | 0.0808 | 0.5 | |
Echinococcus granulosus | nmda type glutamate receptor | 0.0127 | 0.6106 | 0.5993 |
Schistosoma mansoni | lamin | 0.0031 | 0.0808 | 0.0542 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0023 | 0.034 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0023 | 0.034 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.4338 | 0.4174 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.0281 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0023 | 0.034 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0032 | 0.0836 | 0.0571 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.01 | 0.4592 | 0.4436 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0281 | 0.3482 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.0281 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0109 | 0.5088 | 0.4946 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0281 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0127 | 0.6106 | 0.5993 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0281 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0281 | 0.3482 |
Echinococcus granulosus | lamin | 0.0031 | 0.0808 | 0.0542 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0281 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0808 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.0808 | 0.0542 |
Onchocerca volvulus | 0.0031 | 0.0808 | 0.5 | |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.4338 | 0.4174 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0281 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0281 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0808 | 0.0542 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0808 | 0.0542 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0808 | 0.0542 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0023 | 0.034 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0281 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0808 | 0.0542 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0808 | 0.0542 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0808 | 0.0542 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0281 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0808 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0281 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.01 | 0.4592 | 0.4436 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0281 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0808 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0808 | 1 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0023 | 0.034 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.628 uM | Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method | ChEMBL. | 18800760 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.