Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0222 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0222 | 1 |
Echinococcus granulosus | geminin | 0.0173 | 0.6283 | 0.6283 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0142 | 0.4876 | 0.4876 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.6283 | 0.6283 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0222 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0 | 0.5 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0142 | 0.4876 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0253 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.925 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.6283 | 0.6283 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0222 | 0.0222 |
Echinococcus multilocularis | geminin | 0.0173 | 0.6283 | 0.6283 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0138 | 0.4691 | 0.4691 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0142 | 0.4876 | 0.4876 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0222 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0061 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0142 | 0.4876 | 0.4876 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0 | 0.5 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0061 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0222 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0061 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.98 uM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
Inhibition (binding) | = 45 % | Inhibition of HSL in Wistar rat isolated fat cells at 1 uM by spectrophotometric assay | ChEMBL. | 18808096 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.