Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sirtuin 1 | Starlite/ChEMBL | References |
Homo sapiens | sirtuin 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | transcriptional regulatory protein sir2a | sirtuin 2 | 234 aa | 207 aa | 26.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0171 | 1 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0154 | 0.8746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.6973 | 0.6973 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0154 | 0.8746 | 0.8746 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0154 | 0.8746 | 1 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0154 | 0.8746 | 0.8746 |
Giardia lamblia | Hypothetical protein | 0.0154 | 0.8746 | 0.8746 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0171 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0171 | 1 | 1 |
Mycobacterium ulcerans | Sir2-like regulatory protein | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0154 | 0.8746 | 0.8746 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0171 | 1 | 1 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0154 | 0.8746 | 0.8746 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0154 | 0.8746 | 0.8746 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0154 | 0.8746 | 1 |
Leishmania major | silent information regulator 2, putative | 0.0154 | 0.8746 | 1 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0171 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0154 | 0.8746 | 0.8746 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | transcriptional regulator | 0.0154 | 0.8746 | 0.8746 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.004 | 0 | 0.5 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0171 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0171 | 1 | 1 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.004 | 0 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0154 | 0.8746 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0154 | 0.8746 | 0.8746 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0154 | 0.8746 | 0.8746 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.004 | 0 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0154 | 0.8746 | 1 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0154 | 0.8746 | 0.8746 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0154 | 0.8746 | 0.8746 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Toxoplasma gondii | histone deacetylase SIR2-like | 0.004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 5.4 uM | Activation of N-terminal His6-tagged SIRT1 (156 to 664 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac-AMC as substrate after 45 mins by fluorometric analysis | ChEMBL. | 23316803 |
EC50 (binding) | = 16.5 uM | Activation of at N-terminal GST-tagged SIRT2 (34 to 356 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac-AMC as substrate after 45 mins by fluorometric analysis | ChEMBL. | 23316803 |
max activation (binding) | = 206 % | Activation of at N-terminal GST-tagged SIRT2 (34 to 356 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac-AMC as substrate at 50 uM after 45 mins by fluorometric analysis relative to control | ChEMBL. | 23316803 |
max activation (binding) | = 212 % | Activation of N-terminal His6-tagged SIRT1 (156 to 664 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac-AMC as substrate at 50 uM after 45 mins by fluorimetric analysis relative to control | ChEMBL. | 23316803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.