Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | platelet-derived growth factor receptor, beta polypeptide | Starlite/ChEMBL | References |
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Homo sapiens | fibroblast growth factor receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.018 | 0.018 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0044 | 0.018 | 0.018 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0122 | 0.2105 | 0.2105 |
Schistosoma mansoni | Protein orai-1 | 0.0444 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0053 | 0.0408 | 0.0408 |
Schistosoma mansoni | tyrosine kinase | 0.0122 | 0.2105 | 0.2105 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.0444 | 1 | 1 |
Echinococcus multilocularis | neuroglian | 0.0046 | 0.0229 | 0.0229 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0122 | 0.2105 | 0.2105 |
Loa Loa (eye worm) | TK protein kinase | 0.0132 | 0.2334 | 0.2334 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0408 | 0.0408 |
Echinococcus granulosus | twitchin | 0.0046 | 0.0229 | 0.0229 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0179 | 0.3501 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0132 | 0.2334 | 0.2334 |
Schistosoma mansoni | nephrin | 0.0046 | 0.0229 | 0.0229 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0122 | 0.2105 | 0.2105 |
Schistosoma mansoni | Protein orai-1 | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0214 | 0.4347 | 0.4347 |
Schistosoma mansoni | cell adhesion molecule | 0.0044 | 0.018 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0408 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 1 | 1 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0122 | 0.2105 | 0.2105 |
Echinococcus granulosus | roundabout 2 | 0.0053 | 0.0408 | 0.0408 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0214 | 0.4347 | 0.4347 |
Echinococcus granulosus | neuroglian | 0.0046 | 0.0229 | 0.0229 |
Echinococcus granulosus | calcium release activated calcium channel | 0.0444 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.002 uM | Inhibition of human recombinant PDGFRbeta | ChEMBL. | 19113866 |
IC50 (binding) | = 0.009 uM | Inhibition of human recombinant FGFR1 | ChEMBL. | 19113866 |
IC50 (binding) | = 0.027 uM | Inhibition of human recombinant VEGFR2 | ChEMBL. | 19113866 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.