Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor; Grin1/Grin2b | References | |
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Schistosoma mansoni | glutamate receptor NMDA | Glutamate NMDA receptor; Grin1/Grin2b | 938 aa | 933 aa | 39.1 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.5159 | 0.5159 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0104 | 0.5855 | 0.5855 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0046 | 0.1427 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0159 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1097 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0064 | 0.2786 | 0.2786 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1319 | 0.1319 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1319 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0122 | 0.7214 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.5159 | 0.5159 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1319 | 0.1319 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1319 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0046 | 0.1427 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0046 | 0.1427 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0046 | 0.1427 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0046 | 0.1427 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1097 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0104 | 0.5855 | 0.5855 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0046 | 0.1427 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.08 uM | Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method | ChEMBL. | 18800760 |
IC50 (binding) | = 1.2 uM | Displacement of [3H]astemizole from human ERG expressed in HEK293 cells | ChEMBL. | 18800760 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.