Detailed view for Tb927.11.9110

Basic information

TDR Targets ID: 11133
Trypanosoma brucei, C-terminal motor kinesin, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.9121 | Length (AA): 669 | MW (Da): 75092 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00225   Kinesin motor domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0003777   microtubule motor activity  
GO:0008017   microtubule binding  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_126975)

Species Accession Gene Product
Arabidopsis thaliana AT4G27180   kinesin 2
Arabidopsis thaliana AT4G21270   kinesin-like motor protein heavy chain
Arabidopsis thaliana AT4G05190   kinesin 5
Arabidopsis thaliana AT1G72250   Di-glucose binding protein with Kinesin motor domain
Arabidopsis thaliana AT5G54670   kinesin 3
Arabidopsis thaliana AT2G22610   Di-glucose binding protein with Kinesin motor domain
Brugia malayi Bm1_12505   Kinesin-like protein klp-3
Candida albicans CaO19.11581   C terminus of kinesin motor domain protein
Candida albicans CaO19.564   N terminus of kinesin motor domain protein
Candida albicans CaO19.4100   C terminus of kinesin motor domain protein
Caenorhabditis elegans CELE_T09A5.2   Protein KLP-3, isoform C
Caenorhabditis elegans CELE_W02B12.7   Protein KLP-17
Cryptosporidium hominis Chro.30298   kinesin-related protein K2
Cryptosporidium parvum cgd3_2590   kinesin-related protein K2
Dictyostelium discoideum DDB_G0267396   kinesin family member 2
Drosophila melanogaster Dmel_CG7831   non-claret disjunctional
Entamoeba histolytica EHI_119530   kinesin, putative
Echinococcus multilocularis EmuJ_000585600   kinesin family member c
Echinococcus multilocularis EmuJ_001123400   kinesin protein KIFC3
Giardia lamblia GL50803_8886   Kinesin-14
Homo sapiens ENSG00000237649   kinesin family member C1
Homo sapiens ENSG00000140859   kinesin family member C3
Leishmania braziliensis LbrM.28.2020   C-terminal motor kinesin, putative
Leishmania braziliensis LbrM.19.0570   C-terminal motor kinesin, putative
Leishmania donovani LdBPK_190250.1   C-terminal motor kinesin, putative
Leishmania donovani LdBPK_281970.1   C-terminal motor kinesin, putative
Leishmania infantum LinJ.19.0250   C-terminal motor kinesin, putative
Leishmania infantum LinJ.28.1970   C-terminal motor kinesin, putative
Leishmania major LmjF.19.0260   C-terminal motor kinesin, putative
Leishmania major LmjF.28.1850   C-terminal motor kinesin, putative
Leishmania mexicana LmxM.19.0260   C-terminal motor kinesin, putative
Leishmania mexicana LmxM.28.1850   C-terminal motor kinesin, putative
Mus musculus ENSMUSG00000024301   kinesin family member C5B
Mus musculus ENSMUSG00000079553   kinesin family member C1
Mus musculus ENSMUSG00000031788   kinesin family member C3
Oryza sativa 4342193   Os07g0105700
Oryza sativa 4334882   Os03g0862200
Oryza sativa 4337093   Os04g0629700
Oryza sativa 4352796   Os12g0616000
Oryza sativa 4331382   Os03g0114000
Saccharomyces cerevisiae YPR141C   Kar3p
Schmidtea mediterranea mk4.000314.08  
Schmidtea mediterranea mk4.000786.13  
Trypanosoma brucei gambiense Tbg972.11.10180   C-terminal motor kinesin, putative
Trypanosoma brucei gambiense Tbg972.10.18070   C-terminal motor kinesin, putative
Trypanosoma brucei Tb927.11.9110   C-terminal motor kinesin, putative
Trypanosoma brucei Tb11.v5.0625   C-terminal motor kinesin, putative
Trypanosoma brucei Tb927.10.14890   C-terminal motor kinesin, putative
Trypanosoma congolense TcIL3000.11.9460   C-terminal motor kinesin, putative
Trypanosoma cruzi TcCLB.510901.50   C-terminal motor kinesin, putative
Trypanosoma cruzi TcCLB.506211.114   C-terminal motor kinesin, putative

Essentiality

Tb927.11.9110 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14890 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.14890 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.14890 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.14890 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.0850 this record Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.0850 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.0850 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.0850 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T09A5.2 Caenorhabditis elegans embryonic arrest wormbase
CELE_T09A5.2 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) increased (PATO:0000470) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens kinesin family member C1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0024 1 0.5
0.0045 0.3506 0.5
0.0045 0.3506 0.5
0.0024 1 0.5
0.0024 1 0.5
0.0045 0.3506 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.11.9110 (Trypanosoma brucei), C-terminal motor kinesin, putative
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