Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor protein alpha-7 subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Brugia malayi | Kinesin-like protein klp-3 | 0.0045 | 0.3506 | 0.3506 |
Echinococcus multilocularis | kinesin family member c | 0.0045 | 0.3506 | 0.9998 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.9187 | 0.9187 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0015 | 0 | 0.5 |
Giardia lamblia | Kinesin-14 | 0.0045 | 0.3506 | 0.5 |
Onchocerca volvulus | 0.0101 | 1 | 1 | |
Onchocerca volvulus | 0.0101 | 1 | 1 | |
Echinococcus granulosus | glycine receptor subunit beta | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 1 | 1 |
Trypanosoma cruzi | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | nAChR subunit | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0101 | 1 | 1 | |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | kinesin protein KIFC3 | 0.0045 | 0.3506 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Trypanosoma cruzi | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Trypanosoma brucei | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0 | 0.5 |
Leishmania major | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Leishmania major | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5100 nM | Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysis | ChEMBL. | 24814197 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.