Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor protein alpha-7 subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 1 | 1 |
Giardia lamblia | Kinesin-14 | 0.0045 | 0.3506 | 0.5 |
Brugia malayi | Kinesin-like protein klp-3 | 0.0045 | 0.3506 | 0.3506 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family member c | 0.0045 | 0.3506 | 0.9998 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 1 | 1 |
Onchocerca volvulus | 0.0101 | 1 | 1 | |
Trypanosoma brucei | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Trypanosoma cruzi | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Onchocerca volvulus | 0.0101 | 1 | 1 | |
Echinococcus granulosus | nAChR subunit | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Trypanosoma brucei | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Trypanosoma brucei | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | kinesin protein KIFC3 | 0.0045 | 0.3506 | 1 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0015 | 0 | 0.5 |
Leishmania major | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Leishmania major | C-terminal motor kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0045 | 0.3506 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.9187 | 0.9187 |
Onchocerca volvulus | 0.0101 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 46 nM | Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysis | ChEMBL. | 24814197 |
Inhibition (binding) | = 9 % | Inhibition of alpha1beta1gammadelta nAChR (unknown origin) at 10 uM | ChEMBL. | 24814197 |
Inhibition (ADMET) | = 33 % | Inhibition of CYP2C9 (unknown origin) at 10 uM | ChEMBL. | 24814197 |
Inhibition (binding) | = 36 % | Inhibition of human ERG at 1 uM by whole-cell voltage clamp assay | ChEMBL. | 24814197 |
Inhibition (ADMET) | = 49 % | Inhibition of CYP3A4 (unknown origin) at 10 uM | ChEMBL. | 24814197 |
Inhibition (ADMET) | = 50 % | Inhibition of CYP2D6 (unknown origin) at 10 uM | ChEMBL. | 24814197 |
Inhibition (ADMET) | = 63 % | Inhibition of CYP1A2 (unknown origin) at 10 uM | ChEMBL. | 24814197 |
Inhibition (ADMET) | = 78 % | Inhibition of CYP2C19 (unknown origin) at 10 uM | ChEMBL. | 24814197 |
Inhibition (binding) | = 83 % | Inhibition of human alpha4beta2 nAChR expressed in Xenopus oocytes at 10 uM by voltage clamp method | ChEMBL. | 24814197 |
Inhibition (binding) | = 99 % | Inhibition of 5-HT3 receptor (unknown origin) at 10 uM | ChEMBL. | 24814197 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.