Detailed view for Bm1_22930

Basic information

TDR Targets ID: 238484
Brugia malayi, phosphorylase B kinase alpha regulatory chain
Source Database / ID:  GenBank

pI: 5.3734 | Length (AA): 883 | MW (Da): 100607 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00723   Glycosyl hydrolases family 15

Gene Ontology

Mouse over links to read term descriptions.
GO:0005516   calmodulin binding  
GO:0003824   catalytic activity  
GO:0005977   glycogen metabolic process  

Metabolic Pathways

Calcium signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
43 833 2bpt (A) 23 741 10.00 0 0.55 0.87011 0.52
115 815 1z3h (B) 72 763 13.00 0 0.71 0.818184 0.76
366 606 4k92 (A) 298 538 14.00 0 0.13 0.437233 -0.64
478 524 2vso (E) 639 683 33.00 0.92 0.66 0.404128 -0.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130768)

Species Accession Gene Product
Brugia malayi Bm1_22925   hypothetical protein
Brugia malayi Bm1_22930   phosphorylase B kinase alpha regulatory chain
Caenorhabditis elegans CELE_C14B9.8   Protein C14B9.8
Drosophila melanogaster Dmel_CG7766   CG7766 gene product from transcript CG7766-RI
Echinococcus granulosus EgrG_000568500   phosphorylase b kinase regulatory
Echinococcus multilocularis EmuJ_000568500   phosphorylase b kinase regulatory
Homo sapiens ENSG00000044446   phosphorylase kinase, alpha 2 (liver)
Homo sapiens ENSG00000067177   phosphorylase kinase, alpha 1 (muscle)
Loa Loa (eye worm) LOAG_12149   hypothetical protein
Loa Loa (eye worm) LOAG_10953   hypothetical protein
Loa Loa (eye worm) LOAG_10321   hypothetical protein
Mus musculus ENSMUSG00000031295   phosphorylase kinase alpha 2
Mus musculus ENSMUSG00000034055   phosphorylase kinase alpha 1
Onchocerca volvulus OVOC9057   Putative phosphorylase b kinase regulatory subunit alpha
Schistosoma japonicum Sjp_0035630   ko:K00871 phosphorylase kinase gamma subunit [EC2.7.11.19], putative
Schistosoma mansoni Smp_149040   phosphorylase B kinase alpha kpb1
Schmidtea mediterranea mk4.001511.04  
Schmidtea mediterranea mk4.001511.00   Probable phosphorylase b kinase regulatory subunit alpha
Schmidtea mediterranea mk4.001511.01   Probable phosphorylase b kinase regulatory subunit alpha
Schmidtea mediterranea mk4.001511.02   Probable phosphorylase b kinase regulatory subunit alpha

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphorylase kinase, alpha 2 (liver) Compounds References
Homo sapiens phosphorylase kinase, alpha 1 (muscle) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1062 0.516 0.516
0.0532 0.4781 0.4926
0.0548 0.9776 1
0.0988 0.4374 0.4374
0.102 0.6711 0.6948
0.0859 0.4655 0.4792
0.0946 0.3825 0.3791
0.0987 0.7242 0.7494
0.101 0.3716 0.3626
0.092 0.5392 0.5454
0.1062 0.516 0.516
0.0505 0.9778 1
0.1062 0.501 0.501
0.1051 0.2775 0.5114
0.0987 0.7242 0.7494
0.1051 0.2775 0.5114
0.0507 0.4595 0.4675
0.0476 0.9777 1
0.0946 0.3782 0.4822

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_22930 (Brugia malayi), phosphorylase B kinase alpha regulatory chain
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