Detailed view for Smp_161470.3

Basic information

TDR Targets ID: 284353
Schistosoma mansoni, soluble guanylate cyclase gcy
Source Database / ID:  GeneDB

pI: 6.2158 | Length (AA): 1056 | MW (Da): 119446 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00211   Adenylate and Guanylate cyclase catalytic domain
PF00415   Regulator of chromosome condensation (RCC1) repeat
PF07700   Haem-NO-binding
PF07701   Heme NO binding associated
PF13540   Regulator of chromosome condensation (RCC1) repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0020037   heme binding  
GO:0016849   phosphorus-oxygen lyase activity  
GO:0004383   guanylate cyclase activity  
GO:0009190   cyclic nucleotide biosynthetic process  
GO:0007242   intracellular signaling cascade  
GO:0006182   cGMP biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 162 6bde (A) 1 160 22.00 0 0.98 0.509509 -0.87
1 162 4u9b (A) 1 159 19.00 0 1 0.498509 -1.11
1 176 3tfg (A) 1 177 30.00 0 1 0.632267 -0.91
711 1051 5xgs (A) 60 357 40.00 0 1 0.541617 0.65
843 994 4jhn (A) 37 172 35.00 0.000000000014 0.77 0.470639 -0.16
860 1007 3mvd (K) 255 389 30.00 0.0018 1 0.425852 -0.02
863 1037 1a12 (A) 29 198 32.00 0.0000042 0.99 0.39142 0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_171802)

Species Accession Gene Product
Echinococcus granulosus EgrG_001099350   Williams Beuren syndrome chromosomal region 16
Echinococcus multilocularis EmuJ_001099350   Williams Beuren syndrome chromosomal region 16
Schistosoma japonicum Sjp_0046960   Williams-Beuren syndrome chromosomal region 16 protein homolog, putative
Schistosoma japonicum Sjp_0046990   Soluble guanylate cyclase 88E, putative
Schistosoma japonicum Sjp_0046970   hypothetical protein
Schistosoma japonicum Sjp_0046980   Soluble guanylate cyclase 88E, putative
Schistosoma mansoni Smp_161470.1   soluble guanylate cyclase gcy
Schistosoma mansoni Smp_161470.3   soluble guanylate cyclase gcy
Schistosoma mansoni Smp_161470.2   soluble guanylate cyclase gcy
Schmidtea mediterranea mk4.010056.00  
Schmidtea mediterranea mk4.018252.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0299 0.8293 0.8293
0.0148 0.2808 0.2808
0.0141 0.8293 0.8293
0.0314 0.2808 0.2808
0.0309 0.8293 0.8293
0.0149 0.8477 0.8477
0.0146 0.3122 0.3122
0.0164 0.3822 0.3822
0.0301 0.8293 0.8293
0.014 0.2808 0.2808
0.0141 0.5868 0.8293
0.0308 0.4476 0.8293
0.0141 0.5868 0.8293
0.0315 0.4113 0.4104
0.03 0.8293 0.8293
0.0145 0.8293 0.8293
0.0142 0.2808 0.2808
0.0144 0.8293 0.8293
0.0297 0.8293 0.8293
0.0153 0.8293 0.8293
0.0139 0.8293 0.8293
0.0288 0.8293 0.8293
0.0291 0.8293 0.8293
0.0305 0.6808 0.8293
0.0315 0.4113 0.4104
0.0146 0.8293 0.8293
0.0309 0.8293 0.8293
0.0305 0.6808 0.8293
0.017 0.8293 0.8293
0.017 0.2808 0.2808
0.017 0.8233 0.8233

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_161470.3 (Schistosoma mansoni), soluble guanylate cyclase gcy
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