Detailed view for Smp_149040
Basic information
Schistosoma mansoni, phosphorylase B kinase alpha kpb1
Source Database / ID: GeneDB
pI: 6.9001 |
Length (AA): 1298 |
MW (Da): 146725 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0003824 catalytic activity
GO:0005977 glycogen metabolic process
Metabolic Pathways
Structural information
Modbase 3D models:
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_130768)
| Species | Accession | Gene Product |
|---|---|---|
| Brugia malayi | Bm1_22925 | hypothetical protein |
| Brugia malayi | Bm1_22930 | phosphorylase B kinase alpha regulatory chain |
| Caenorhabditis elegans | CELE_C14B9.8 | Protein C14B9.8 |
| Drosophila melanogaster | Dmel_CG7766 | CG7766 gene product from transcript CG7766-RI |
| Echinococcus granulosus | EgrG_000568500 | phosphorylase b kinase regulatory |
| Echinococcus multilocularis | EmuJ_000568500 | phosphorylase b kinase regulatory |
| Homo sapiens | ENSG00000044446 | phosphorylase kinase, alpha 2 (liver) |
| Homo sapiens | ENSG00000067177 | phosphorylase kinase, alpha 1 (muscle) |
| Loa Loa (eye worm) | LOAG_12149 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_10953 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_10321 | hypothetical protein |
| Mus musculus | ENSMUSG00000031295 | phosphorylase kinase alpha 2 |
| Mus musculus | ENSMUSG00000034055 | phosphorylase kinase alpha 1 |
| Onchocerca volvulus | OVOC9057 | Putative phosphorylase b kinase regulatory subunit alpha |
| Schistosoma japonicum | Sjp_0035630 | ko:K00871 phosphorylase kinase gamma subunit [EC2.7.11.19], putative |
| Schistosoma mansoni | Smp_149040 | phosphorylase B kinase alpha kpb1 |
| Schmidtea mediterranea | mk4.001511.04 | |
| Schmidtea mediterranea | mk4.001511.00 | Probable phosphorylase b kinase regulatory subunit alpha |
| Schmidtea mediterranea | mk4.001511.01 | Probable phosphorylase b kinase regulatory subunit alpha |
| Schmidtea mediterranea | mk4.001511.02 | Probable phosphorylase b kinase regulatory subunit alpha |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Homo sapiens | phosphorylase kinase, alpha 1 (muscle) | Compounds | References |
| Homo sapiens | phosphorylase kinase, alpha 2 (liver) | Compounds | References |
By sequence similarity to non orthologous druggable targets
Obtained from network model
Ranking Plot
Putative Drugs List
Assayability
Assay information
Reagent availability
Bibliographic References