Detailed view for Smp_149980

Basic information

TDR Targets ID: 292962
Schistosoma mansoni, soluble guanylate cyclase gcy
Source Database / ID:  GeneDB

pI: 5.1789 | Length (AA): 696 | MW (Da): 79197 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00211   Adenylate and Guanylate cyclase catalytic domain
PF07700   Haem-NO-binding
PF07701   Heme NO binding associated

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0020037   heme binding  
GO:0016849   phosphorus-oxygen lyase activity  
GO:0004383   guanylate cyclase activity  
GO:0009190   cyclic nucleotide biosynthetic process  
GO:0007242   intracellular signaling cascade  
GO:0006182   cGMP biosynthetic process  

Metabolic Pathways

Purine metabolism (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
311 600 1y10 (A) 92 374 23.00 0 1 0.548067 0.4
346 684 4rl5 (B) 210 582 27.00 0.93 0.97 0.535369 0.52
419 593 4ni2 (A) 475 646 48.00 0 1 0.884837 -0.89
421 603 5oyh (A) 448 625 37.00 0 1 0.821231 -1.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128451)

Species Accession Gene Product
Brugia malayi Bm1_16095   Adenylate and Guanylate cyclase catalytic domain containing protein
Caenorhabditis elegans CELE_C46E1.2   Protein GCY-36
Caenorhabditis elegans CELE_T04D3.4   Protein GCY-35, isoform C
Caenorhabditis elegans CELE_C06B3.8   Protein GCY-32
Caenorhabditis elegans CELE_F57F5.2   Protein GCY-33, isoform A
Caenorhabditis elegans CELE_T07D1.1   Protein GCY-31, isoform A
Caenorhabditis elegans CELE_M04G12.3   Protein GCY-34
Drosophila melanogaster Dmel_CG1470   Guanylyl cyclase beta-subunit at 100B
Drosophila melanogaster Dmel_CG4154   Guanylyl cyclase at 88E
Homo sapiens ENSG00000061918   guanylate cyclase 1, soluble, beta 3
Loa Loa (eye worm) LOAG_01062   guanylyl cyclase/natriuretic peptide receptor
Loa Loa (eye worm) LOAG_01677   hypothetical protein
Mus musculus ensembl-mmu:ENSMUSG00000028005   guanylate cyclase 1, soluble, beta 3
Mus musculus ENSMUSG00000021933   guanylate cyclase 1, soluble, beta 2
Onchocerca volvulus OVOC10925  
Schistosoma japonicum Sjp_0042760   Soluble guanylate cyclase 88E, putative
Schistosoma japonicum Sjp_0103840   Soluble guanylate cyclase gcy-33, putative
Schistosoma mansoni Smp_149980   soluble guanylate cyclase gcy
Schmidtea mediterranea mk4.020607.00   Guanylate cyclase
Schmidtea mediterranea mk4.011788.02   Soluble guanylate cyclase gcy-31
Schmidtea mediterranea mk4.037184.00   Soluble guanylate cyclase gcy-31
Schmidtea mediterranea mk4.002386.01  
Schmidtea mediterranea mk4.001829.00  
Schmidtea mediterranea mk4.004824.04   Soluble guanylate cyclase gcy-33
Schmidtea mediterranea mk4.002386.04  
Schmidtea mediterranea mk4.026152.00  
Schmidtea mediterranea mk4.015094.00   Soluble guanylate cyclase gcy-33
Schmidtea mediterranea mk4.002742.01   Soluble guanylate cyclase gcy-33
Schmidtea mediterranea mk4.024294.00   Soluble guanylate cyclase gcy-33
Schmidtea mediterranea mk4.011788.00  
Schmidtea mediterranea mk4.006066.01  
Schmidtea mediterranea mk4.002386.02   Head-specific guanylate cyclase
Schmidtea mediterranea mk4.000049.24   Head-specific guanylate cyclase

Essentiality

Smp_149980 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F57F5.2 Caenorhabditis elegans adult lethal wormbase
CELE_F57F5.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F57F5.2 Caenorhabditis elegans larval lethal wormbase
CELE_F57F5.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens guanylate cyclase 1, soluble, beta 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0161 0.7075 1
0.0358 0.4704 0.4696
0.0165 1 1
0.0341 1 1
0.0161 1 1
0.0163 1 1
0.0158 1 1
0.0173 1 1
0.0338 1 1
0.0328 1 1
0.0331 1 1
0.0358 0.4704 0.4696
0.0166 1 1
0.0346 0.796 1
0.0351 1 1
0.0346 0.796 1
0.0193 1 1
0.0193 1 1
0.0193 1 1
0.0339 1 1
0.0168 1 1
0.016 1 1
0.0357 1 1
0.0351 1 1
0.017 1 1
0.0166 0.3582 0.3582
0.0186 0.4609 0.4609
0.0342 1 1
0.0159 1 1
0.0161 0.7075 1
0.035 0.5397 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_149980 (Schistosoma mansoni), soluble guanylate cyclase gcy
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