Detailed view for PF3D7_0831800

Basic information

TDR Targets ID: 321992
Plasmodium falciparum, histidine-rich protein II
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.0161 | Length (AA): 305 | MW (Da): 32409 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05403   Plasmodium histidine-rich protein (HRPII/III)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
123 299 4ke2 (A) 6 169 39.00 0.009 0.01 0.713228 1.8
274 303 2eoz (A) 8 37 7.00 0.016 0 -0.103639 2.29
29 80 2k8i (A) 122 171 36.00 0.14 0.01 0.30587 2.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Oocyst, Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Female Gametocyte. Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_210391)

Species Accession Gene Product
Plasmodium falciparum PF3D7_1372200   histidine-rich protein III
Plasmodium falciparum PF3D7_0831800   histidine-rich protein II

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

83 chemical compounds are associated with this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.2633 1 1
1.01514 0.406599 1
3.6427 0.5575 1
0.8578 1 1
0.773 0.4586 1
0.256 0.723 1
7.0016 1 1
0.256 1 1
0.2438 1 1
0.4903 0.693 1
10.2339 1 1
0.2896 1 0.5
1.3794 1 1
0.256 1 1
0.3048 1 1
2.2469 1 1
4.4625 1 1
1.01514 0.406599 1
1.4999 1 1
0.3048 0.2852 0.5
7.0016 1 1
0.2545 1 1
0.2871 1 1
7.0016 1 1
0.3048 1 0.5
0.2438 0.9406 1
3.43459 1 1
1.01514 0.406599 1
0.3048 1 0.5
1.0067 1 0.5
0.246 0.3143 0.769
0.237 0.296 1
4.0491 1 1
0.398824 0.257248 1
1.1414 0.3377 1
0.5048 1 1
1.0822 1 1
0.2482 1 1
0.2585 1 1
1.3975 1 1
0.5081 1 1
0.2758 1 1
1.3794 1 1
1.01514 0.406599 1
3.6427 0.5575 1
1.0084 1 1
0.2467 1 1
0.3048 1 0.5
0.264 1 1
7.0016 1 1
0.5012 1 1
7.0016 1 1
3.6427 0.5575 1
0.263 0.9933 1
0.2857 0.2797 1
0.3074 1 1
0.2779 1 1
0.2505 0.9681 1
0.5 1 1
0.785 0.4688 1
0.5013 1 0.5
0.5463 1 0.5
0.2465 0.7347 1
0.5371 1 0.5
0.5073 1 1
2.6249 1 1
0.3048 1 1
0.3236 1 1
3.6905 1 1
0.3048 1 1
6.5105 1 1
0.2444 1 1
0.2651 1 1
0.246 0.3143 0.769
8.6138 1 1
1.5829 1 0.5
3.803 1 1
0.5317 0.5 0.5
0.4903 0.693 1
0.246 1 1
1.0611 1 0.5
1.01514 0.406599 1
0.246 0.3143 0.769
0.398824 0.25725 1
1.0736 1 1
0.2911 0.7782 1
3.6427 0.5575 1
0.25 0.3761 1
0.8009 1 1
0.2896 1 1
0.3074 1 1
0.4208 0.6745 1
1.5894 0.5 0.5
0.2482 1 1
1.8487 1 1
4.3053 1 1
0.6615 0.2748 1
1.0653 1 0.5
0.2521 0.4797 1
1.5652 1 0.5
4.4552 1 1
0.7706 1 0.5
0.8188 0.5872 1
0.3048 1 1
0.584 1 1
6.6084 1 1
0.7633 1 1
3.6427 0.5575 1
3.6427 0.5575 1
0.2438 1 1
0.2496 0.7687 1
1.4373 1 1
0.7831 1 1
1.4512 1 1
0.3062 1 1
0.5178 0.8995 1
0.4226 1 1
1.2777 0.5 0.5
0.5052 1 1
1.0509 1 0.5
0.8053 1 1
0.7839 1 1
7.0016 1 1
1.5829 1 0.5
1.01514 0.406599 1
0.2876 1 1
7.0016 1 1
0.246 0.3143 0.769
3.6427 0.5575 1
0.2472 1 1
0.5246 1 1
1.9984 1 1
0.2508 1 1
8.6138 1 1
0.3048 0.2549 0.9967
0.2505 0.3279 1
0.2894 1 1
3.6427 0.5575 1
0.7545 1 1
1.01514 0.406599 1
8.6138 1 1
0.2779 1 1
0.8108 1 1
6.5105 1 1
1.3123 1 1
7.0016 1 1
4.0491 1 1
1.4048 1 0.5
0.6717 1 1
0.2494 0.9649 1
0.3048 1 0.5
0.7659 0.5 0.5
0.5085 0.3593 0.7793
7.0016 1 1
7.0016 1 1
8.6138 1 1
0.3 0.9135 1
0.5337 1 1
3.6427 0.5575 1
3.6905 1 1
1.0582 1 1
0.2894 1 1
0.2618 1 1
0.8418 1 1
0.2502 0.3227 1
0.246 0.3143 0.769
1.01514 0.406599 1
1.0584 1 1
0.28 0.4435 1
0.9716 0.3504 1
6.6084 1 1
2.6249 1 1
0.9984 1 1
0.2899 1 0.5
0.2502 0.3227 1
0.2917 0.5454 1
7.0016 1 1
2.6092 1 1
6.6084 1 1
0.5184 1 1
1.8743 1 1
4.3053 1 1
1.0174 1 1
0.7647 1 1
0.4985 1 1
1.5669 1 1
1.7966 0.2934 1
7.0016 1 1
0.8053 1 1
1.0577 1 1
0.2382 0.2886 1
0.5162 1 1
0.2673 1 1
1.2777 0.5 0.5
1.01514 0.406599 1
0.9984 1 1
1.0148 1 1
0.2438 1 1
1.4048 1 0.5
0.2911 0.7782 1
0.579 1 1
0.2508 1 1
0.2687 1 1
0.8053 1 1
0.7994 1 0.5
0.2508 1 1
7.0016 1 1
0.749 1 1
0.2779 1 1
0.5085 0.3593 0.7793
7.0016 1 1
0.28 0.4435 1
0.9984 1 1
2.6249 1 1
1.01514 0.406599 1
1.0577 1 1
0.3048 0.5 0.5
0.2438 1 1
0.256 0.723 1
3.6427 0.5575 1
0.4536 1 0.5
0.246 0.3143 0.769
0.437 1 1
1.5894 0.5 0.5
0.7736 1 1
3.43459 1 1
1.0597 1 0.5
0.2871 1 1
0.2491 1 1
0.2662 1 1
1.071 1 1
0.5137 1 1
3.6427 0.5575 1
3.6427 0.5575 1
0.28 0.4435 1
3.6427 0.5575 1
0.4903 1 1
1.0694 1 1
7.0016 1 1
6.5105 1 1
0.9984 1 1
7.0016 1 1
0.2482 1 1
0.5085 0.3593 0.7793
0.2505 0.3279 1
1.0302 1 1
3.6905 1 1
1.3794 1 1
7.0016 1 1
0.3048 1 0.5
0.2673 1 1
6.6084 1 1
0.9213 1 1
0.5012 1 1
4.4552 1 1
6.6084 1 1
0.2642 1 1
0.5215 0.5 0.5
0.5328 1 1
0.786 1 1
1.9912 0.5921 1
0.7567 1 1
0.4903 1 1
1.01514 0.406599 1
0.3048 1 0.5
3.6905 1 1
0.2502 0.7422 1
7.0016 1 1
0.2911 1 1
3.6427 0.5575 1
7.0016 1 1
0.5085 0.3593 0.7793
3.6427 0.5575 1
0.246 0.3143 0.769
0.2689 1 0.5
7.0016 1 1
0.6855 0.6809 1
0.5323 1 1
1.5829 1 0.5
1.3344 1 1
1.6523 1 0.5
0.579 1 1
0.2836 1 1
0.2734 0.398 1
0.246 0.3143 0.769
1.01514 0.406599 1
2.5806 1 1
0.8414 1 1
0.4932 0.6573 1
0.2593 1 1
3.6427 0.5575 1
1.9364 1 1
0.283 0.5321 1
3.43459 1 1
0.4188 1 1
6.6084 1 1
0.2462 0.7448 1
0.2505 0.3279 1
0.398824 0.257248 1
0.246 0.3143 0.769
1.5192 1 1
6.5105 1 1
1.0638 1 1
0.4981 1 0.5
0.5462 1 0.5
6.6084 1 1
0.25 0.3761 1
0.5329 1 1
0.5107 1 1
3.6427 0.5575 1
1.5894 0.5 0.5
3.6427 0.5575 1
0.3048 1 1
3.6427 0.5575 1
4.1347 1 1
7.0016 1 1
0.4008 0.2523 1
8.6138 1 1
0.2836 1 1
0.6897 0.4381 1
4.4625 1 1
7.0016 1 1
0.5085 0.3593 0.7793
0.3048 0.6182 1
0.246 0.3143 0.769
7.0016 1 1
0.5789 1 1
3.6427 0.5575 1
0.27 1 1
7.0016 1 1
0.9984 1 1
0.237 0.4774 1
0.283 0.5321 1
0.8578 1 1
0.542 1 1
1.3975 1 1
1.6228 0.3494 1
0.2445 1 1
7.0016 1 1
1.0754 1 1
7.67 0.3141 1
1.01514 0.406599 1
0.5408 1 1
6.5105 1 1
6.5105 1 1
0.3048 1 0.5
0.2723 1 1
0.265 0.2831 1
0.265 0.2831 1
0.2894 1 1
0.2758 1 1
3.0541 1 1
0.2836 0.4441 1
0.5246 1 1
0.7937 1 1
0.8418 1 1
0.2836 1 1
1.0743 1 1
0.2618 1 1
0.5303 1 0.5
0.3954 0.3106 1
1.3794 1 1
0.2857 0.2797 1
7.0016 1 1
4.0491 1 1
0.4927 1 1
0.532 1 1
0.5085 0.3593 0.7793
0.5085 0.3593 0.7793
0.2494 0.9561 1
3.6427 0.5575 1
3.4825 1 1
0.246 0.3143 0.769
1.01514 0.406599 1
7.0016 1 1
8.6138 1 1
0.3048 1 1
0.5648 1 1
0.8498 1 1
0.8509 1 1
8.6138 1 1
3.6427 0.5575 1
0.498 1 0.5
3.6427 0.5575 1
0.2894 1 1
0.329891 1 1
0.5085 0.3593 0.7793
7.0016 1 1
0.2857 0.2797 1
0.3048 1 1
3.6427 0.5575 1
1.0694 1 1
0.2876 1 1
0.2515 1 0.5
0.2894 1 1
8.6138 1 1
1.1106 1 1
1.3344 1 1
0.1473 0.904 1
0.283 1 1
1.0867 1 1
3.6905 1 1
0.5286 1 1
0.4932 0.6573 1
0.2619 1 1
0.2857 1 1
1.3794 1 1
0.5085 0.3593 0.7793
3.0541 1 1
0.2896 0.7143 1
7.0016 1 1
0.6897 0.3321 1
0.256 0.6766 0.6765
0.2592 1 1
1.0638 1 1
1.5822 1 1
0.2494 0.9648 1
7.0016 1 1
1.3794 1 1
0.2526 1 1
0.3048 0.5 0.5
0.2504 1 1
0.4963 1 1
1.01514 0.406599 1
7.0016 1 1
0.7993 1 1
7.0016 1 1
3.6905 1 1
0.2767 1 1
0.3048 0.5 0.5
0.246 0.3143 0.769
0.2775 1 1
1.01514 0.406599 1
7.0016 1 1
0.5912 1 1
0.2642 1 1
3.4825 1 1
0.246 0.3143 0.769
1.0466 1 1
0.2521 0.4797 1
7.0016 1 1
0.498 1 0.5
0.3048 1 1
0.2382 0.2886 1
0.3048 1 0.5
1.9984 1 1
0.759 1 1
2.7457 1 1
0.4985 0.5 0.5
0.5032 1 1
0.2505 0.3279 1
1.01514 0.406599 1
0.25 0.3761 1
0.2459 1 1
0.2857 0.2797 1
0.5034 1 1
0.265 0.2831 1
7.0016 1 1
3.6427 0.5575 1
7.0016 1 1
0.2601 1 1
1.9984 1 1
1.3254 1 1
6.5105 1 1
4.1347 1 1
0.98137 1 1
3.6427 0.5575 1
1.01514 0.406599 1
1.0536 1 1
0.3545 1 1
4.4247 1 1
3.6427 0.5575 1
0.246 0.3143 0.769
3.6427 0.5575 1
0.7789 1 1
0.2502 0.3227 1
0.6181 0.3262 1
0.506 1 1
1.0086 1 1
7.0016 1 1
1.4373 1 1
0.3048 1 1
0.2619 1 1
8.6138 1 1
7.0016 1 1
8.6138 1 1
0.2467 1 1
1.0736 1 1
0.398824 0.257248 1
0.6897 0.3321 1
0.4912 1 0.5
0.7534 0.5 0.5
4.3053 1 1
0.2911 0.7782 1
0.2824 0.8523 1
0.7922 1 1
0.5085 0.3593 0.7793
0.2496 0.7687 1
0.2487 1 1
1.2973 1 1
1.01514 0.406599 1
0.5381 1 1
7.0016 1 1
7.0016 1 1
0.4471 1 1
1.01514 0.406599 1
1.052 1 1
0.2505 0.9412 1
0.2797 1 1
0.3048 0.6453 1
0.2593 1 1
1.0638 1 1
7.0016 1 1
0.4205 1 1
6.5105 1 1
1.046 1 1
7.0016 1 1
0.2775 1 1
0.2512 1 1
0.2438 1 1
3.6427 0.5575 1
7.0016 1 1
0.576 1 1
0.3048 1 1
0.7948 1 1
0.2574 1 0.5
0.2521 0.4797 1
0.398824 0.257248 1
3.6427 0.5575 1
0.2857 0.2797 1
6.5105 1 1
3.6427 0.5575 1
3.6427 0.5575 1
0.5403 1 0.5
4.4625 1 1
1.2777 0.5 0.5
3.6427 0.5575 1
7.0016 1 1
6.5105 1 1
0.2894 1 1
0.4903 1 1
0.5046 1 1
0.2894 1 1
7.0016 1 1
7.0016 1 1
0.4932 0.6573 1
0.542 1 1
0.2494 0.9648 1
1.01514 0.406599 1
0.5221 1 1
8.6138 1 1
0.3048 1 1
3.6905 1 1
0.59 1 0.5
0.3 0.9135 1
0.3048 1 0.5
3.6427 0.5575 1
7.0016 1 1
0.8188 0.5872 1
3.6427 0.5575 1
0.2382 0.2886 1
0.541 1 1
0.246 0.3143 0.769
1.01514 0.406599 1
1.0644 1 1
0.2869 1 1
0.2525 1 1
6.5105 1 1
0.2527 1 1
6.5105 1 1
8.6138 1 1
0.5012 1 1
0.5646 1 1
0.2458 0.7368 1
0.256 0.6766 0.6765
0.2462 0.7448 1
1.01514 0.406599 1
0.5453 1 0.5
3.6905 1 1
0.2512 1 1
1.9984 1 1
3.6427 0.5575 1
0.246 0.3143 0.769
0.5085 0.3593 0.7793
0.246 0.3143 0.769
0.246 0.3143 0.769
1.052 1 1
1.0638 1 1
1.9984 1 1
0.2762 0.4029 1
0.2495 1 1
1.0603 1 1
0.5085 0.3593 0.7793
0.3048 1 1
0.5119 1 0.5
3.0541 1 1
0.5085 0.3593 0.7793
1.01514 0.406599 1
0.398824 1 0.5
0.2601 1 1
0.254 1 1
6.5105 1 1
0.7975 1 1
0.398824 0.257248 1
0.2496 0.7687 1
0.8414 1 1
0.2444 1 0.5
0.2445 1 1
0.8108 0.7674 1
0.2472 1 1
1.01514 0.406599 1
7.0016 1 1
0.28 0.4435 1
0.2584 1 1
0.5396 0.9303 1
2.3695 0.5662 1
0.2857 0.2797 1
1.3794 1 1
6.6084 1 1
1.4048 1 0.5
0.398824 0.257248 1
0.4903 1 1
0.2472 1 1
0.3434 1 0.5
0.2465 0.7347 1
0.2894 1 1
0.2494 1 1
3.6427 0.5575 1
1.0168 1 1
7.0016 1 1
1.0736 1 1
0.3048 0.6182 1
0.246 1 1
0.7608 0.5 0.5
0.5112 1 1
1.01514 0.406599 1
0.2619 1 1
0.2521 1 1
0.2917 1 1
0.2911 0.7782 1
0.398824 0.257248 1
11.8412 1 1
0.7659 0.5 0.5
3.6427 0.5575 1
1.5188 1 1
0.2739 1 1
0.7726 1 1
0.5361 1 1
7.0016 1 1
0.25 0.3761 1
4.0491 1 1
0.2841 1 1
0.703 0.5 0.5
0.2521 0.4792 1
0.2491 1 1
0.2914 1 1
7.0016 1 1
1.01514 0.406599 1
1.043 0.5 0.5
0.773 0.5875 1
0.5178 0.8995 1
0.246 0.3143 0.769
0.5085 0.3593 0.7793
0.398824 0.25725 1
7.0016 1 1
7.0016 1 1
3.6427 0.5575 1
0.2521 0.4792 1
0.3048 1 0.5
0.2714 1 1
7.0016 1 1
3.6427 0.5575 1
0.2642 1 1
1.8743 1 1
3.6905 1 1
0.5347 1 1
0.2505 0.3279 1
3.6427 0.5575 1
0.5085 0.3593 0.7793
1.01514 0.406599 1
2.6249 1 1
1.6242 1 1
8.6138 1 1
3.6427 0.5575 1
0.370336 1 1
0.2797 1 1
8.6138 1 1
0.3048 1 1
0.9213 0.3508 1
0.2911 0.7782 1
8.6138 1 1
1.3123 1 1
0.2613 0.5681 1
0.4536 1 0.5
0.2496 0.7687 1
0.2462 0.7218 1
1.0731 1 1
4.3053 1 1
0.2445 1 0.5
3.6427 0.5575 1
1.0731 1 1
0.5085 0.3593 0.7793
7.0016 1 1
1.6242 1 1
0.5002 1 0.5
0.7789 0.5 0.5
0.3048 1 0.5
6.5105 1 1
0.3048 1 1
7.0016 1 1
6.6084 1 1
0.2841 1 1
1.01514 0.406599 1
0.8498 1 1
0.8578 1 1
0.7911 1 0.5
7.0016 1 1
0.7909 1 1
0.8128 1 1
0.3048 1 1
0.3048 0.5 0.5
1.3261 1 1
1.01514 0.406599 1
0.256 0.723 1
0.2472 1 1
7.0016 1 1
3.6427 0.5575 1
1.052 1 1
3.6427 0.5575 1
0.5085 0.3593 0.7793
0.2467 0.8975 1
0.5894 0.604 1
0.2502 0.6788 1
3.6905 1 1
0.3236 1 1
3.6427 0.5575 1
7.0016 1 1
1.9984 1 1
3.6427 0.5575 1
1.3975 1 1
0.2525 1 1
0.2521 0.6553 1
7.0016 1 1
7.0016 1 1
1.5148 1 0.5
0.9716 1 1
0.9984 1 1
0.5521 1 1
7.0016 1 1
1.0754 1 1
0.2508 1 1
0.9419 1 0.5
3.6905 1 1
0.3954 0.3106 1
3.6905 1 1
0.2642 1 1
7.0016 1 1
1.3344 1 1
0.28 0.4435 1
0.59 1 0.5
7.0016 1 1
0.7675 1 1
0.2894 1 1
0.256 0.723 1
0.2519 1 1
6.6084 1 1
0.265 0.2831 1
0.2494 1 1
0.2584 1 1
0.7642 1 0.5
0.2505 0.3279 1
7.0016 1 1
8.6138 1 1
3.6427 0.5575 1
1.0067 1 0.5
7.0016 1 1
0.2508 1 1
0.5112 1 1
0.5085 0.3593 0.7793
0.6897 0.4381 1
0.5063 1 0.5
1.4048 1 0.5
0.2505 1 1
0.246 0.3143 0.769
0.8188 0.5872 1
3.6427 0.5575 1
0.3048 0.5 0.5
3.0541 1 1
3.6427 0.5575 1
3.6905 1 1
1.0148 1 1
0.542 1 1
7.0016 1 1
2.2886 1 1
0.2445 1 1
0.28 0.4435 1
0.3048 1 0.5
0.3048 1 0.5
7.0016 1 1
0.7908 0.5 0.5
8.6138 1 1
0.2894 1 1
0.2573 1 1
0.2521 1 1
0.25 0.3761 1
0.2505 0.9681 1
0.3048 1 0.5
1.01514 0.406599 1
0.7814 1 0.5
3.43459 1 1
0.2506 0.4779 1
0.2779 1 1
3.6427 0.5575 1
7.0016 1 1
0.4953 1 1
0.8188 0.5872 1
6.2864 0.7619 1
0.7789 1 1
1.0644 1 1
1.4373 1 1
1.9334 1 1
1.9984 1 1
0.8418 1 1
2.6249 1 1
0.4188 1 1
0.25 0.3761 1
0.7641 0.8376 1
0.5088 1 1
7.0016 1 1
0.254 1 1
1.668 1 1
0.8128 1 1
0.265 0.2831 1
0.7641 0.8376 1
8.6138 1 1
0.2687 1 1
0.2446 0.7374 1
0.5012 1 1
0.7888 1 0.5
0.398824 1 0.5
0.9984 1 1
7.0016 1 1
8.6138 1 1
3.6427 0.5575 1
0.2869 1 1
0.5184 1 1
0.8127 1 0.5
0.7775 1 1
7.0016 1 1
0.246 0.3143 0.769
0.2444 1 1
1.0536 1 1
0.246 0.3143 0.769
7.0016 1 1
0.2625 1 1
3.6427 0.5575 1
1.0378 1 1
2.6249 1 1
0.5155 1 1
0.8418 1 1
0.5315 1 1
1.5148 1 0.5
3.6427 0.5575 1
3.6427 0.5575 1
0.2814 1 1
6.5105 1 1
0.5013 1 0.5
0.2602 1 1
7.0016 1 1
0.8418 1 1
1.9984 1 1
0.8188 0.5872 1
1.5623 1 1
3.0541 1 1
7.0016 1 1
0.2521 1 1
0.4422 1 0.5
3.6427 0.5575 1
2.6249 1 1
3.0541 1 1
0.4208 0.6745 1
0.2459 1 1
0.5085 0.3593 0.7793
0.2589 1 1
0.2491 1 1
0.4579 0.5 0.5
0.9089 0.3718 1
0.9984 1 1
0.6123 1 0.5
0.3048 1 1
7.0016 1 1
0.4208 0.6745 1
7.0016 1 1
1.0086 1 1
1.9569 0.7622 1
1.0067 1 0.5
0.7901 1 1
1.0576 1 1
0.782 1 1
0.7348 1 1
7.0016 1 1
0.3048 1 1
3.6427 0.5575 1
0.7922 1 1
3.6427 0.5575 1
0.2687 1 1
8.6138 1 1
1.01514 0.406599 1
8.6138 1 1
8.6138 1 1
6.6084 1 1
3.6905 1 1
0.7641 0.8376 1
1.01514 0.406599 1
0.2876 1 1
7.0016 1 1
0.3048 0.5 0.5
0.9577 1 1
0.2487 1 0.5
7.0016 1 1
0.265 0.2831 1
0.7641 0.8376 1
0.5012 1 1
8.6138 1 1
0.2684 1 1
7.0016 1 1
0.5178 0.8995 1
7.0016 1 1
1.3794 1 1
0.7875 1 0.5
1.3794 1 1
3.0541 1 1
1.0536 1 1
0.5085 0.3593 0.7793
3.6427 0.5575 1
0.2601 1 1
0.2589 1 1
0.2527 1 1
3.43459 1 1
0.2576 1 1
0.4927 1 1
0.7839 1 0.5
0.2447 1 1
7.0016 1 1
0.5004 1 1
8.6138 1 1
0.4522 1 1
5.6316 0.6144 1
0.3048 1 1
0.5085 0.3593 0.7793
3.6905 1 1
0.9984 1 1
6.6084 1 1
3.43459 1 1
0.2491 1 1
4.1347 1 1
1.0644 1 1
0.3048 1 0.5
1.3794 1 1
0.7545 1 1
0.2444 1 0.5
0.2641 0.5 0.5
7.0016 1 1
3.6427 0.5575 1
0.8418 1 1
1.0319 1 1
0.5012 1 1
0.6895 0.491 1
7.0016 1 1
0.2494 1 1
0.2797 1 1
3.6427 0.5575 1
0.256 0.6766 0.6765
1.3145 1 1
0.498 1 0.5
0.5407 1 1
0.8414 1 1
0.1815 0.4343 1
8.6138 1 1
7.0016 1 1
0.2491 1 1
0.246 0.3143 0.769
0.2866 1 1
7.0016 1 1
1.1323 1 1
0.7728 0.6261 1
3.6427 0.5575 1
1.046 1 1
0.3954 0.3106 1
0.2824 0.8523 1
0.2445 1 1
0.2569 1 1
0.7641 0.8376 1
0.2824 0.8523 1
0.3048 0.7002 0.5
0.2779 1 1
0.3048 1 1
1.0638 1 1
0.7641 0.8376 1
0.2593 1 1
1.054 1 1
0.2521 0.4792 1
1.3975 1 1
0.5174 1 1
1.01514 0.406599 1
1.5623 1 1
0.398824 1 1
0.2445 1 1
3.43459 1 1
0.782 1 1
0.3048 1 0.5
0.2917 1 1
0.2896 0.7143 1
0.5229 1 1
3.6427 0.5575 1
1.3254 1 1
0.2438 1 1
0.25 0.3761 1
0.5085 0.3593 0.7793
3.1487 1 1
0.2894 1 1
0.2459 1 1
0.787 1 1
0.265 0.2831 1
1.3794 1 1
3.6427 0.5575 1
0.8128 1 1
0.2618 1 1
0.3062 1 1
0.2438 1 1
0.2438 1 1
6.6084 1 1
0.5396 0.9303 1
3.6427 0.5575 1
0.2382 0.2886 1
0.5155 1 1
1.0577 1 1
0.2687 1 1
0.4903 1 1
3.43459 1 1
8.6138 1 1
1.0577 1 1
0.8578 1 1
0.4993 1 1
7.0016 1 1
0.7425 1 1
0.2508 1 1
0.5085 0.3593 0.7793
0.3048 1 0.5
0.2595 0.7437 1
1.0577 1 1
0.283 0.3714 1
2.6249 1 1
0.5161 1 1
0.2917 0.5454 1
0.3116 0.2682 1
0.4903 1 1
0.265 0.2831 1
0.3048 0.5 0.5
0.5085 0.3593 0.7793
0.2521 0.4797 1
0.2836 0.4441 1
2.7457 1 1
4.4552 1 1
0.4987 1 1
3.6427 0.5575 1
7.0016 1 1
3.6427 0.5575 1
0.3048 0.6529 1
0.25 0.3761 1
3.6427 0.5575 1
0.532 1 1
7.0016 1 1
2.2886 1 1
0.246 0.3143 0.769
2.0648 1 0.5
0.5353 1 0.5
3.6905 1 1
0.246 0.3143 0.769
1.0638 1 1
3.6427 0.5575 1
0.498 1 1
0.2525 1 1
0.279 1 1
0.265 0.2831 1
0.283 0.3714 1
0.773 0.8024 1
0.2894 1 1
1.01514 0.406599 1
0.3048 1 0.5
1.052 1 1
0.7937 1 1
0.2894 1 1
0.25 0.3761 1
0.2446 0.7374 1
0.2204 0.3338 1
1.0644 1 1
6.6084 1 1
7.0016 1 1
1.3399 1 0.5
0.3074 1 1
0.2467 0.8975 1
1.27127 1 1
4.0491 1 1
0.2589 1 1
0.246 1 1
0.9984 1 1
3.6427 0.5575 1
0.2689 1 1
0.6065 0.5738 1
3.6427 0.5575 1
1.9334 1 1
3.6905 1 1
0.9439 0.2974 1
0.246 0.3143 0.769
0.4972 1 0.5
1.557 1 0.5
4.1347 1 1
0.841 1 1
1.3794 1 1
0.4932 0.6573 1
0.2527 0.9827 1
0.2824 0.8523 1
3.6427 0.5575 1
0.2445 1 1
0.2917 0.5454 1

Assayability

Assay information

  • Compound was evaluated for inhibition of haem detoxification by beta haematin formation employed by P. falciparum ChEMBL
  • Inhibition of beta-hematin formation in Plasmodium falciparum
  • Compound was evaluated for the inhibition of hematin polymerization ChEMBL
  • Inhibition of hematin polymerization
  • Inhibition of formation of beta hematin induced by 1-monooleoyl glycerol (MOG) ChEMBL
  • Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formation
  • Inhibition of beta-hematin formation ChEMBL
  • Inhibition of beta-hematin formation
  • Compound was tested for its ability to inhibit the formation of beta hematin induced by 1-monooleoyl glycerol (MOG) at 200 uM concentration ChEMBL
  • Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formation at 200 uM
  • Compound was tested for its ability to inhibit the formation of beta hematin induced by 1-monooleoyl glycerol (MOG) at a concentration of 200 uM ChEMBL
  • Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formation at 200 uM
  • Compound was tested for its inhibitory activity against beta-hematin formation ChEMBL
  • Inhibitory activity against beta-hematin formation
  • In vitro inhibition of beta-hematin formation. ChEMBL
  • In vitro inhibition of beta-hematin formation
  • Evaluated for the hemozoin in Chloroquine resistant P. berghei ChEMBL
  • Hemozoin formation in chloroquine-resistant Plasmodium berghei
  • Evaluated for the hemozoin in Chloroquine resistant P. berghei which is treated with 15 mg/kg body weight of compound for 10 days ChEMBL
  • Hemozoin formation in chloroquine-resistant Plasmodium berghei at 15 mg/kg for 10 days
  • Evaluated for the hemozoin in Chloroquine sensitive P. berghei ChEMBL
  • Hemozoin formation in chloroquine-sensitive Plasmodium berghei
  • Evaluated for the hemozoin in Chloroquine resistant P. yoelii ChEMBL
  • Hemozoin formation in chloroquine-resistant Plasmodium yoelii
  • Evaluated for the hemozoin in Chloroquine resistant P. yoelii which is treated with 15 mg/kg body weight of compound for 10 days ChEMBL
  • Hemozoin formation in chloroquine-resistant Plasmodium yoelii at 15 mg/kg for 10 days
  • Evaluated for the hemozoin in Chloroquine sensitive P. yoelii ChEMBL
  • Hemozoin formation in chloroquine-sensitive Plasmodium yoelii
  • Inhibition of hemozoin formation in mice infected with Plasmodium berghei at 5 uM ChEMBL
  • Inhibition of hemozoin formation in Plasmodium berghei infected mice (Mus musculus) at 5 uM
  • Inhibition of hemozoin formation in mice infected with Plasmodium berghei at 100 uM ChEMBL
  • Inhibition of hemozoin formation in Plasmodium berghei infected mice (Mus musculus) at 100 uM
  • In vitro ability of the compound to inhibit beta-hematin(synthetic equivalent of hemozoin) formation in Plasmodium falciparum (percentage of inhibition at 100 uM) ChEMBL
  • In vitro inhibition of beta-hematin formation in Plasmodium falciparum at 100 uM
  • Inhibition of beta-hematin formation induced by 1-monooleoyl glycerol ChEMBL
  • Inhibition of 1-monooleoyl glycerol induced beta-hematin formation
  • Inhibition of lipid-induced beta-hematin formation ChEMBL
  • Inhibition of lipid-induced beta-hematin formation
  • Inhibition of beta-hematin formation by BHIA assay ChEMBL
  • Inhibition of beta-hematin formation by BHIA assay
  • Inhibition of beta hematin formation ChEMBL
  • Inhibition of beta-hematin formation
  • Inhibition of Tween 20-induced beta hematin formation by colorimetric assay ChEMBL
  • Inhibition of Tween 20-induced beta-hematin formation by colorimetric assay
  • Inhibition of beta hematin polymerization ChEMBL
  • Inhibition of beta-hematin polymerization
  • Inhibition of hemozoin formation in presence of hemin chloride and acetate buffer at 1.25 uM to 25 mM after 48 hrs relative to control ChEMBL
  • Inhibition of hemozoin formation in presence of hemin chloride and acetate buffer at 1.25 uM to 25 mM after 48 hrs relative to control
  • Inhibition of beta-hematin formation at 5 mM ChEMBL
  • Inhibition of beta-hematin formation at 5 mM
  • Inhibition of beta-hematin formation at 10 mM ChEMBL
  • Inhibition of beta-hematin formation at 10 mM
  • Inhibition of beta-hematin formation at 1 to 20 mM ChEMBL
  • Inhibition of beta-hematin formation at 1 to 20 mM
  • Inhibition of beta-hematin formation at 5.7 mM ChEMBL
  • Inhibition of beta-hematin formation at 5.7 mM
  • Inhibition of beta-hematin formation at 11.4 mM ChEMBL
  • Inhibition of beta-hematin formation at 11.4 mM
  • Inhibition of beta-hematin formation at 4.2 mM ChEMBL
  • Inhibition of beta-hematin formation at 4.2 mM
  • Inhibition of beta-hematin formation at 8.4 ChEMBL
  • Inhibition of beta-hematin formation at 8.4
  • Inhibition of beta-hematin formation ChEMBL
  • Inhibition of beta-hematin formation
  • ChEMBL
  • Inhibition of beta-hematin formation by BHIA assay
  • ChEMBL
  • Inhibition of beta-hematin formation after 16 hrs
  • ChEMBL
  • Inhibition of hemozoin formation after 48 hrs in chloroquine-sensitive Plasmodium falciparum NF54
  • ChEMBL
  • Inhibition of hemozoin formation after 48 hrs in multi drug-resistant Plasmodium yoelii
  • ChEMBL
  • Inhibition of beta-hematin formation using synthetic hemin chloride
  • ChEMBL
  • Inhibition of beta-hematin formation assessed as inhibition of flavoprotein polymerization at 5 to 100 mM after 48 hrs
  • ChEMBL
  • Inhibition of acetate buffer-induced hemozoin formation at 1.25 to 25 mM/well after 48 hrs
  • ChEMBL
  • Inhibition of beta-hematin formation as molar equivalent relative to hemin causing blockade in BHIA
  • ChEMBL
  • Antiplasmodial activity as inhibition of beta-hematin against Plasmodium yoelii N67 infected Swiss mice (Mus musculus) erythrocytes
  • ChEMBL
  • Inhibition of beta-hematin formation after 18 hrs by microtiter plate assay
  • ChEMBL
  • Inhibition of beta-hematin formation at 5 milliequivalent after 18 hrs by microtiter plate assay

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0831800 (Plasmodium falciparum), histidine-rich protein II
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