Detailed information for compound 1039474

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 307.409 | Formula: C19H17NOS
  • H donors: 0 H acceptors: 1 LogP: 4.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(c1cccnc1)Sc1ccccc1
  • InChi: 1S/C19H17NOS/c1-21-17-11-9-15(10-12-17)19(16-6-5-13-20-14-16)22-18-7-3-2-4-8-18/h2-14,19H,1H3
  • InChiKey: YPZVNIWZTCHCDE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum histidine-rich protein II Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum histidine-rich protein III Get druggable targets OG5_210391 All targets in OG5_210391
Plasmodium falciparum histidine-rich protein II Get druggable targets OG5_210391 All targets in OG5_210391
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0027 0.0419
Brugia malayi glutathione reductase 0.0046 0.0126 0.0443
Loa Loa (eye worm) hypothetical protein 0.0166 0.0519 0.147
Trypanosoma cruzi Heat shock protein 83, putative 0.0048 0.0134 0.0472
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0453 0.1465 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.0226
Brugia malayi MH1 domain containing protein 0.0014 0.0019 0.0069
Trypanosoma brucei heat shock protein, putative 0.0048 0.0134 0.0472
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0003 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0061 0.0216
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0029 0.0069 0.0234
Echinococcus multilocularis muscleblind protein 0.0166 0.0519 0.1771
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0025 0.0071
Mycobacterium leprae Probable two-component sensor kinase 0.0048 0.0134 0.3738
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0048 0.0134 0.4126
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0014 0.0021 0.0021
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.011 0.0313
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0027 0.0095
Trypanosoma brucei multidrug resistance protein E 0.0027 0.0064 0.0226
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0039 0.0039
Schistosoma mansoni pyruvate dehydrogenase 0.0821 0.2674 0.9439
Schistosoma mansoni multidrug resistance protein 0.0027 0.0064 0.0226
Echinococcus granulosus Smad4 0.0025 0.0056 0.0197
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0029 0.0069 0.0242
Schistosoma mansoni Smad4 0.0025 0.0056 0.0197
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0048 0.0134 0.0472
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0048 0.0134 0.0472
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0111
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0203 0.0643 0.2269
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0424 0.1496
Schistosoma mansoni smad1 5 8 and 0.0025 0.0056 0.0197
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0048 0.0134 0.0472
Mycobacterium ulcerans hypothetical protein 0.0026 0.0061 0.095
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0025 0.0085
Trypanosoma brucei p-glycoprotein 0.0027 0.0064 0.0226
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0027 0.0095
Entamoeba histolytica heat shock protein 90, putative 0.0048 0.0134 0.2079
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0056 0.0158
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0011 0.0031
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0061 0.0216
Loa Loa (eye worm) hypothetical protein 0.0048 0.0134 0.0378
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0061 0.095
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0027 0.0064 0.0181
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0126 0.604
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0029 0.0069 0.0242
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0048 0.0134 0.0912
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0048 0.0134 0.0912
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0095
Echinococcus granulosus heat shock protein 90 0.0048 0.0134 0.0472
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0208 0.0589
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0206 0.0582
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0056 0.0197
Mycobacterium ulcerans putative regultory protein 0.0048 0.0134 0.2079
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0088
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0319 0.2177
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0052 0.0184
Mycobacterium tuberculosis Probable reductase 0.0105 0.0319 0.2177
Echinococcus multilocularis tar DNA binding protein 0.007 0.0206 0.0701
Echinococcus multilocularis microtubule associated protein 2 0.0765 0.249 0.8497
Loa Loa (eye worm) TOPoisomerase family member 0.0048 0.0134 0.0378
Plasmodium falciparum heat shock protein 90 0.0048 0.0134 0.0134
Giardia lamblia Synaptic glycoprotein SC2 0.0029 0.0069 0.3905
Onchocerca volvulus 0.0106 0.0324 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0437 0.1542
Echinococcus granulosus tar DNA binding protein 0.007 0.0206 0.0726
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0111
Mycobacterium tuberculosis Conserved protein 0.0071 0.0208 0.1419
Brugia malayi RNA binding protein 0.007 0.0206 0.0726
Echinococcus multilocularis protein dispatched 1 0.0053 0.015 0.0513
Brugia malayi MH2 domain containing protein 0.0362 0.1164 0.411
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0027 0.0095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0134 0.0378
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0208 0.0734
Trypanosoma brucei heat shock protein, putative 0.0048 0.0134 0.0472
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0036 0.0243
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0029 0.0069 0.1067
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0052 0.0147
Echinococcus multilocularis smad 0.0025 0.0056 0.019
Echinococcus granulosus snurportin 1 0.0341 0.1097 0.3871
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0129 0.0439
Plasmodium vivax DNA topoisomerase II, putative 0.0048 0.0134 0.6425
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0092
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0048 0.0164
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0056 0.0197
Brugia malayi beta-lactamase family protein 0.0071 0.0208 0.0734
Loa Loa (eye worm) transcription factor SMAD2 0.0362 0.1164 0.3296
Echinococcus granulosus Niemann Pick C1 protein 0.0156 0.0487 0.1721
Loa Loa (eye worm) hypothetical protein 0.005 0.0139 0.0392
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0319 0.2177
Mycobacterium tuberculosis Conserved protein 0.0071 0.0208 0.1419
Brugia malayi CHE-14 protein 0.0047 0.0129 0.0454
Entamoeba histolytica DNA topoisomerase II, putative 0.0048 0.0134 0.2079
Brugia malayi Niemann-Pick C1 protein precursor 0.0109 0.0333 0.1177
Loa Loa (eye worm) hypothetical protein 0.0081 0.0242 0.0686
Entamoeba histolytica hypothetical protein 0.004 0.0106 0.1646
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0095
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0061 0.095
Echinococcus granulosus smad 0.0025 0.0056 0.0197
Echinococcus multilocularis protein patched 0.0047 0.0129 0.0439
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0208 1
Leishmania major trypanothione reductase 0.0046 0.0126 0.0443
Loa Loa (eye worm) hypothetical protein 0.0166 0.0519 0.147
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0029 0.0069 0.3299
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0055
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Loa Loa (eye worm) hypothetical protein 0.0109 0.0333 0.0944
Schistosoma mansoni smad 0.0025 0.0056 0.0197
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0064 0.0997
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0029 0.0069 0.1067
Mycobacterium tuberculosis Conserved protein 0.0048 0.0134 0.0912
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0126 0.0857
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0048 0.0134 0.2079
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0134 0.0472
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0029 0.0069 0.0242
Schistosoma mansoni Smad4 0.0011 0.0011 0.0038
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0048 0.0134 0.0912
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0048 0.0134 0.0472
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0027 0.0419
Giardia lamblia Heat shock protein HSP 90-alpha 0.0048 0.0134 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.006 0.0211
Loa Loa (eye worm) hypothetical protein 0.0047 0.0129 0.0364
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.008 0.0226
Echinococcus multilocularis multidrug resistance associated protein 1 0.0027 0.0064 0.0219
Schistosoma mansoni multidrug resistance protein 0.0027 0.0064 0.0226
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0196 0.0692
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0027 0.0064 0.0226
Loa Loa (eye worm) beta-lactamase 0.0071 0.0208 0.0589
Echinococcus multilocularis bloom syndrome protein 0.0016 0.0028 0.0095
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0208 0.1419
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0011 0.0031
Entamoeba histolytica hypothetical protein 0.004 0.0106 0.1646
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0357 0.2439
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0129 0.0364
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0048 0.017
Trichomonas vaginalis DNA helicase recq, putative 0.0009 0.0003 0.0047
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Schistosoma mansoni microtubule-associated protein tau 0.0765 0.249 0.879
Trypanosoma brucei heat shock protein, putative 0.0048 0.0134 0.0472
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0011 0.0037
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.011 0.5314
Trypanosoma cruzi DNA topoisomerase II, putative 0.0048 0.0134 0.0472
Echinococcus multilocularis heat shock protein 90 0.0048 0.0134 0.0456
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0134 0.0471
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0095
Echinococcus granulosus synaptic glycoprotein sc2 0.0029 0.0069 0.0242
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0048 0.0134 1
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0048 0.0134 0.2079
Echinococcus granulosus geminin 0.0356 0.1146 0.4045
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0208 0.1419
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0208 0.0734
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0027 0.0076
Toxoplasma gondii DNA topoisomerase 2, putative 0.0048 0.0134 0.0378
Mycobacterium leprae Probable lipase LipE 0.0071 0.0208 0.5818
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0061 0.095
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0208 0.1419
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Brugia malayi Synaptic glycoprotein SC2 0.0029 0.0069 0.0242
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0126 0.0443
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0048 0.0134 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0061 0.095
Schistosoma mansoni smad 0.0011 0.0011 0.0038
Mycobacterium leprae Probable two component sensor kinase MprB 0.0048 0.0134 0.3738
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.001 0.0029
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0319 0.2177
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0027 0.0076
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0064 0.0997
Schistosoma mansoni hypothetical protein 0.0045 0.0123 0.0434
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0048 0.0134 0.0912
Leishmania major ABC-thiol transporter 0.0027 0.0064 0.0226
Brugia malayi MH2 domain containing protein 0.0011 0.0011 0.0038
Trypanosoma brucei heat shock protein, putative 0.0048 0.0134 0.0472
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0048 0.0134 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0129 0.2001
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0111
Schistosoma mansoni hypothetical protein 0.0022 0.0048 0.017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0061 0.095
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0139 0.0489
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0869 0.2833 1
Schistosoma mansoni ran 0.0024 0.0052 0.0184
Echinococcus granulosus multidrug resistance associated protein 1 0.0027 0.0064 0.0226
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0208 0.3235
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0036 0.0243
Echinococcus multilocularis Niemann Pick C1 protein 0.0156 0.0487 0.1664
Loa Loa (eye worm) hypothetical protein 0.1082 0.3532 1
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0048 0.0134 0.0912
Toxoplasma gondii heat shock protein 90, putative 0.0048 0.0134 0.0378
Trichomonas vaginalis heat shock protein, putative 0.0048 0.0134 0.2079
Brugia malayi heat shock protein 90 0.0048 0.0134 0.0472
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0203 0.0643 1
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0208 0.5818
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0048 0.0134 0.0472
Entamoeba histolytica ABC transporter, putative 0.0027 0.0064 0.0997
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0027 0.0064 0.0226
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0056 0.019
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0333 0.1138
Brugia malayi ABC transporter transmembrane region family protein 0.0027 0.0064 0.0226
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0173
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0056 0.0197
Toxoplasma gondii ABC1 family protein 0.0071 0.0208 0.0589
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0048 0.0134 0.2079
Brugia malayi hypothetical protein 0.0032 0.008 0.0284
Leishmania major hypothetical protein, conserved 0.0071 0.0208 0.0734
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0048 0.0134 0.2079
Echinococcus granulosus microtubule associated protein 2 0.0765 0.249 0.879
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0095
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0126 0.0443
Schistosoma mansoni heat shock protein 0.0048 0.0134 0.0472
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0052 0.0184
Schistosoma mansoni blooms syndrome DNA helicase 0.0013 0.0017 0.0059
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0027 0.0095
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0048 0.0134 0.0378
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0208 0.3235
Plasmodium falciparum thioredoxin reductase 0.0046 0.0126 0.0126
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0208 0.071
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0181
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0208 0.3235
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0052 0.0184
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0208 0.1419
Echinococcus granulosus expressed conserved protein 0.0102 0.0312 0.11
Plasmodium falciparum histidine-rich protein II 0.3048 1 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0048 0.0134 0.6425
Loa Loa (eye worm) hypothetical protein 0.0071 0.0208 0.0589
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0134 0.0472
Schistosoma mansoni hypothetical protein 0.0341 0.1097 0.3871
Trichomonas vaginalis esterase, putative 0.0071 0.0208 0.3235
Entamoeba histolytica Ran family GTPase 0.0024 0.0052 0.0809
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0025 0.0085
Echinococcus multilocularis importin subunit beta 1 0.0032 0.008 0.0272
Schistosoma mansoni smad1 5 8 and 0.0025 0.0056 0.0197
Giardia lamblia Multidrug resistance-associated protein 1 0.0027 0.0064 0.3482
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0039 0.061
Trypanosoma brucei heat shock protein, putative 0.0048 0.0134 0.0472
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0106 0.0361
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0869 0.2833 1
Entamoeba histolytica hypothetical protein 0.0027 0.0064 0.0997
Echinococcus granulosus bloom syndrome protein 0.0016 0.0028 0.0098
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0061 0.0216
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0352 0.1133 0.3207
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0027 0.0419
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0203 0.0643 0.2269
Trichomonas vaginalis DNA helicase recq1, putative 0.0016 0.0028 0.0432
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0196 0.0692
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.0339 0.1197
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0056 0.0158
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0869 0.2833 0.9666
Schistosoma mansoni smad1 5 8 and 0.0025 0.0056 0.0197
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0025 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0196 0.3049
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0048 0.0134 0.2079
Schistosoma mansoni survival motor neuron protein 0.0106 0.0324 0.1143
Echinococcus granulosus muscleblind protein 0.0166 0.0519 0.1833
Schistosoma mansoni pyruvate dehydrogenase 0.0821 0.2674 0.9439
Echinococcus granulosus survival motor neuron protein 1 0.052 0.1687 0.5954
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.008 0.0281
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0052 0.2347
Schistosoma mansoni importin beta-1 0.0032 0.008 0.0281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0149 0.0524
Trypanosoma brucei heat shock protein 90, putative 0.0048 0.0134 0.0472
Schistosoma mansoni tar DNA-binding protein 0.007 0.0206 0.0726
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0208 0.1419
Leishmania major hypothetical protein, conserved 0.0048 0.0134 0.0472
Entamoeba histolytica hypothetical protein 0.004 0.0106 0.1646
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0203 0.0643 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0061 0.095
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0196 0.0692
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0208 0.1419
Loa Loa (eye worm) hypothetical protein 0.0033 0.0083 0.0236
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0088
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0052 0.0177
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0048 0.0134 0.2079
Leishmania major developmentally regulated phosphoprotein-like protein 0.0869 0.2833 1
Brugia malayi hypothetical protein 0.052 0.1687 0.5954
Trichomonas vaginalis receptor histidine kinase, putative 0.0048 0.0134 0.2079
Schistosoma mansoni hypothetical protein 0.0045 0.0123 0.0434
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0013 0.0046
Trichomonas vaginalis sensor histidine kinase, putative 0.0048 0.0134 0.2079
Chlamydia trachomatis DNA gyrase subunit B 0.0048 0.0134 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0048 0.0134 0.0378
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0064 0.0997
Schistosoma mansoni tar DNA-binding protein 0.007 0.0206 0.0726
Leishmania major importin beta-1 subunit, putative 0.0026 0.006 0.0211
Trypanosoma brucei trypanothione reductase 0.0046 0.0126 0.0443
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0095
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0304 0.0974 0.2757
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0029 0.0069 0.0242
Loa Loa (eye worm) nuclear factor I 0.0014 0.0019 0.0055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0149 0.0524
Schistosoma mansoni hypothetical protein 0.0045 0.0123 0.0434
Echinococcus multilocularis heat shock protein 0.0048 0.0134 0.0456
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Plasmodium falciparum importin beta, putative 0.0032 0.008 0.008
Loa Loa (eye worm) RNA binding protein 0.007 0.0206 0.0582
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0083 0.0294
Mycobacterium ulcerans lipase LipD 0.0071 0.0208 0.3235
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0027 0.0095
Loa Loa (eye worm) acetyltransferase 0.014 0.0437 0.1236
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0173
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0027 0.0184
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0099 0.1543
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0139 0.0139
Trichomonas vaginalis importin beta-1, putative 0.0026 0.006 0.0931
Leishmania major p-glycoprotein e 0.0027 0.0064 0.0226
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0048 0.0134 0.0472
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0048 0.0134 0.2079
Leishmania major DNA topoisomerase ii 0.0048 0.0134 0.0472
Schistosoma mansoni heat shock protein 0.0048 0.0134 0.0472
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0027 0.0095
Plasmodium vivax endoplasmin, putative 0.0048 0.0134 0.6425
Onchocerca volvulus 0.0071 0.0208 0.6422
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0029 0.0069 0.0069
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0126 0.0356
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0027 0.0064 0.0226
Schistosoma mansoni endoplasmin 0.0048 0.0134 0.0472
Loa Loa (eye worm) hypothetical protein 0.0071 0.0208 0.0589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0149 0.0524
Schistosoma mansoni hypothetical protein 0.0356 0.1146 0.4045
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0208 0.3235
Onchocerca volvulus 0.0029 0.0069 0.2118
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0139 0.0489
Brugia malayi MH1 domain containing protein 0.0025 0.0056 0.0197
Trypanosoma brucei heat shock protein, putative 0.0048 0.0134 0.0472
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.006 0.0931
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0203 0.0643 0.2269
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0095
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0106 0.0373
Mycobacterium ulcerans two component regulator - sensor kinase 0.0048 0.0134 0.2079
Brugia malayi Smad1 0.0025 0.0056 0.0197
Plasmodium vivax glutathione reductase, putative 0.0046 0.0126 0.604
Trichomonas vaginalis DNA topoisomerase II, putative 0.0048 0.0134 0.2079
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0069 0.1067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0036 0.0243
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0027 0.0064 0.0226
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0194
Entamoeba histolytica hypothetical protein 0.004 0.0106 0.1646
Echinococcus multilocularis GPCR, family 2 0.0015 0.0025 0.0085
Loa Loa (eye worm) hypothetical protein 0.1082 0.3532 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0011 0.0038
Plasmodium falciparum DNA gyrase subunit B 0.0048 0.0134 0.0134
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0208 0.0734
Loa Loa (eye worm) hypothetical protein 0.0048 0.0134 0.0378
Schistosoma mansoni multidrug resistance protein 0.0027 0.0064 0.0226
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0052 0.25
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0208 0.0734
Schistosoma mansoni hypothetical protein 0.0356 0.1146 0.4045
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0061 0.0417
Chlamydia trachomatis DNA gyrase subunit B 0.0048 0.0134 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0437 0.149
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0027 0.0027
Brugia malayi Importin beta-1 subunit 0.0032 0.008 0.0281
Trypanosoma brucei heat shock protein, putative 0.0048 0.0134 0.0472
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0029 0.0069 0.1067
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0061 0.095
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0203 0.0643 0.2269
Brugia malayi kinase, mitochondrial precursor 0.0869 0.2833 1
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.1082 0.3532 1
Echinococcus multilocularis muscleblind protein 1 0.0166 0.0519 0.1771
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0106 0.0373
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Loa Loa (eye worm) TAR-binding protein 0.007 0.0206 0.0582
Schistosoma mansoni DNA topoisomerase II 0.0048 0.0134 0.0472
Onchocerca volvulus 0.0026 0.0061 0.1885
Onchocerca volvulus 0.0071 0.0208 0.6422
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0139 0.6661
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0319 0.2177
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0048 0.0134 0.2079
Trypanosoma cruzi DNA topoisomerase II, putative 0.0048 0.0134 0.0472
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.011 0.039
Toxoplasma gondii hypothetical protein 0.1082 0.3532 1
Echinococcus granulosus GPCR family 2 0.0015 0.0025 0.0088
Mycobacterium ulcerans DNA gyrase subunit B 0.0048 0.0134 0.2079
Trypanosoma brucei heat shock protein 90, putative 0.0048 0.0134 0.0472
Toxoplasma gondii heat shock protein HSP90 0.0048 0.0134 0.0378
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0048 0.0134 0.0472
Echinococcus multilocularis geminin 0.0356 0.1146 0.391
Plasmodium falciparum endoplasmin, putative 0.0048 0.0134 0.0134
Echinococcus granulosus multidrug resistance associated protein 4 0.0021 0.0043 0.0153
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.011 0.0313
Mycobacterium tuberculosis Conserved protein 0.0071 0.0208 0.1419
Leishmania major GTP-binding protein, putative 0.0024 0.0052 0.0184
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0139 0.0392
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0173
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Brugia malayi MH1 domain containing protein 0.0014 0.0019 0.0069
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0099 0.0099
Trichomonas vaginalis receptor histidine kinase, putative 0.0048 0.0134 0.2079
Echinococcus granulosus heat shock protein 0.0048 0.0134 0.0472
Giardia lamblia ABC transporter, putative 0.0027 0.0064 0.3482
Giardia lamblia MRP-like ABC transporter 0.0027 0.0064 0.3482
Brugia malayi beta-lactamase 0.0071 0.0208 0.0734
Schistosoma mansoni hypothetical protein 0.004 0.0106 0.0373
Brugia malayi MH1 domain containing protein 0.0025 0.0056 0.0197
Echinococcus granulosus multidrug resistance associated protein 7 0.0027 0.0064 0.0226
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0029 0.0069 0.0194
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0048 0.0134 0.0472
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0061 0.1708
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0208 0.0734
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0048 0.0134 0.4126
Mycobacterium ulcerans beta-lactamase 0.0071 0.0208 0.3235
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0056 0.019
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0304 0.0974 0.3438
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0027 0.1296
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0194
Trichomonas vaginalis heat shock protein, putative 0.0048 0.0134 0.2079
Loa Loa (eye worm) hypothetical protein 0.0071 0.0208 0.0589
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.008 0.0281
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0048 0.0134 0.0912
Echinococcus multilocularis expressed conserved protein 0.0102 0.0312 0.1064
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0048 0.0134 0.0912
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.011 0.1719
Giardia lamblia Multidrug resistance-associated protein 1 0.0027 0.0064 0.3482
Mycobacterium ulcerans hypothetical protein 0.0071 0.0208 0.3235
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0011 0.0508
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0095
Loa Loa (eye worm) hypothetical protein 0.0071 0.0208 0.0589
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0027 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0899 0.293 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0052 0.0052
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0869 0.2833 0.9666
Entamoeba histolytica hypothetical protein 0.0029 0.0069 0.1067
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0196 0.0669
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0357 1
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0111
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0025 0.0088
Mycobacterium ulcerans two component sensor kinase MprB 0.0048 0.0134 0.2079
Schistosoma mansoni tar DNA-binding protein 0.007 0.0206 0.0726
Trypanosoma cruzi heat shock protein 90, putative 0.0048 0.0134 0.0472
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0013 0.0046
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0003 0.0011
Schistosoma mansoni ran 0.0024 0.0052 0.0184
Echinococcus multilocularis Smad4 0.0025 0.0056 0.019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0061 0.0417
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0208 0.3235
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.011 0.1719
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0196 0.3049
Loa Loa (eye worm) hypothetical protein 0.0048 0.0134 0.0378
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0129 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0069 0.1067
Loa Loa (eye worm) hypothetical protein 0.052 0.1687 0.4775
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0129 0.0454
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Echinococcus multilocularis survival motor neuron protein 1 0.052 0.1687 0.5756
Trypanosoma brucei DNA topoisomerase ii 0.0048 0.0134 0.0472
Entamoeba histolytica recQ family helicase, putative 0.0009 0.0003 0.0047
Schistosoma mansoni hypothetical protein 0.0045 0.0123 0.0434
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0061 0.0216
Loa Loa (eye worm) hypothetical protein 0.0071 0.0208 0.0589
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0208 0.3235
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0011 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0111
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0027 0.0064 0.0226
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0048 0.0134 0.2079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0025 0.0088
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0203 0.0643 0.182
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0048 0.0134 0.2079
Brugia malayi MH2 domain containing protein 0.0025 0.0056 0.0197
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0319 0.8925
Mycobacterium ulcerans hypothetical protein 0.0203 0.0643 1
Brugia malayi multidrug resistance related protein 1 0.0027 0.0064 0.0226
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0357 0.2439
Trypanosoma brucei Heat shock protein 83, putative 0.0048 0.0134 0.0472
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0208 0.1419
Brugia malayi Bloom's syndrome protein homolog 0.0016 0.0028 0.0098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0095
Loa Loa (eye worm) endoplasmin 0.0048 0.0134 0.0378
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0003 0.0011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0419
Toxoplasma gondii thioredoxin reductase 0.0046 0.0126 0.0356
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0357 0.2439
Mycobacterium tuberculosis Probable two component sensor kinase 0.0048 0.0134 0.0912
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0025 0.0088
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0203 0.0643 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0061 0.095
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0319 0.2177
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0052 0.0184
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0039 0.1149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0149 0.0507
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0048 0.0134 0.2079
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0203 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0179
Leishmania major pentamidine resistance protein 1 0.0027 0.0064 0.0226
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0304 0.0974 0.3438
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0149 0.042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0149 0.0507
Brugia malayi RNA, U transporter 1 0.0091 0.0274 0.0966
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0341 0.1097 0.3105
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0027 0.0064 0.0226
Trypanosoma brucei heat shock protein, putative 0.0048 0.0134 0.0472
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0011 0.0335
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0039 0.0268
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0208 0.3235
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0011 0.0038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0134 0.0471
Giardia lamblia Pms1-like protein 0.0048 0.0134 1
Trypanosoma brucei developmentally regulated phosphoprotein 0.0869 0.2833 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0061 0.1708
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.006 0.0931
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0029 0.0069 0.1067
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Trichomonas vaginalis ran, putative 0.0024 0.0052 0.0809
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0437 0.1542
Loa Loa (eye worm) MH2 domain-containing protein 0.0362 0.1164 0.3296
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0027 0.0064 0.0226
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0126 0.0429
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0048 0.0134 0.3738
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0061 0.0216
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0088
Schistosoma mansoni endoplasmin 0.0048 0.0134 0.0472
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0048 0.0134 0.4126
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Schistosoma mansoni multidrug resistance protein 0.0027 0.0064 0.0226
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.0294
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0048 0.0134 0.0912
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0048 0.0134 0.2079
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0061 0.095
Loa Loa (eye worm) glutathione reductase 0.0046 0.0126 0.0356
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0088
Plasmodium falciparum DNA topoisomerase 2 0.0048 0.0134 0.0134
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0196 0.0555
Schistosoma mansoni Smad4 0.0011 0.0011 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0061 0.0216
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0048 0.0134 0.0912
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0203 0.0643 0.2269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0149 0.0524
Plasmodium falciparum glutathione reductase 0.0046 0.0126 0.0126
Brugia malayi beta-lactamase family protein 0.0071 0.0208 0.0734
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0333 0.1177
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0048 0.0134 0.0912
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0095
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0048 0.0134 0.0456
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0206 0.0726
Schistosoma mansoni tar DNA-binding protein 0.007 0.0206 0.0726
Trypanosoma cruzi heat shock protein 90, putative 0.0048 0.0134 0.0472
Brugia malayi TAR-binding protein 0.007 0.0206 0.0726
Echinococcus granulosus importin subunit beta 1 0.0032 0.008 0.0281
Brugia malayi hypothetical protein 0.004 0.0106 0.0373
Plasmodium vivax heat shock protein 86, putative 0.0048 0.0134 0.6425
Trypanosoma cruzi hypothetical protein 0.0021 0.0043 0.0153
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0196 0.0692
Loa Loa (eye worm) multidrug resistance-associated protein 0.0021 0.0044 0.0125
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0109 0.0333 0.5189
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0029 0.0069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0181
Loa Loa (eye worm) heat shock protein 90 0.0048 0.0134 0.0378
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0027 0.0095
Brugia malayi Endoplasmin precursor 0.0048 0.0134 0.0472
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0134 0.0472
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0029 0.0069 0.1067
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0029 0.0069 0.0242
Entamoeba histolytica hypothetical protein 0.0026 0.006 0.0931
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0095
Plasmodium falciparum glutathione reductase 0.0016 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0071 0.0208 0.0589
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0048 0.0134 0.2079
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0048 0.0134 1
Echinococcus multilocularis synaptic glycoprotein sc2 0.0029 0.0069 0.0234
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0139 0.0489
Loa Loa (eye worm) hypothetical protein 0.1082 0.3532 1
Entamoeba histolytica heat shock protein 90, putative 0.0048 0.0134 0.2079
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0048 0.0134 0.0472
Leishmania major hypothetical protein, conserved 0.005 0.0139 0.0489
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0048 0.0134 0.3738
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0134 0.6425
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0139 0.0139
Plasmodium vivax importin-beta 2, putative 0.0032 0.008 0.3834
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0011 0.0037
Trypanosoma cruzi multidrug resistance protein E, putative 0.0027 0.0064 0.0226
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0048 0.0134 0.0912
Plasmodium vivax polyprenol reductase, putative 0.0029 0.0069 0.3299
Leishmania major mitochondrial DNA topoisomerase II 0.0048 0.0134 0.0472
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0061 0.095
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0052 0.0147
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0196 0.3049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0095
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0048 0.0134 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0027 0.0063 0.3415
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.0324 0.1143
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0036 0.0243
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0196 0.1337
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0048 0.0134 0.0134
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0099 0.6772
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0027 0.0095
Brugia malayi Thioredoxin reductase 0.0046 0.0126 0.0443
Entamoeba histolytica multidrug resistance protein, putative 0.0027 0.0064 0.0997
Brugia malayi MH2 domain containing protein 0.0025 0.0056 0.0197
Brugia malayi hypothetical protein 0.005 0.0139 0.0489
Schistosoma mansoni hypothetical protein 0.0106 0.0324 0.1143
Plasmodium falciparum polyprenol reductase, putative 0.0029 0.0069 0.0069
Schistosoma mansoni pyruvate dehydrogenase 0.0869 0.2833 1
Plasmodium falciparum thioredoxin reductase 0.0016 0.0027 0.0027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0149 0.0524
Brugia malayi Muscleblind-like protein 0.0166 0.0519 0.1833
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0027 0.1296
Loa Loa (eye worm) hypothetical protein 0.0057 0.0163 0.0462
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0064 0.0997
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0027 0.0419
Loa Loa (eye worm) hypothetical protein 0.0869 0.2833 0.8019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0149 0.0524
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0304 0.0974 0.3438
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0208 0.0734
Loa Loa (eye worm) Smad1 0.0025 0.0056 0.0158
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0039 0.1885
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0208 0.0734
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0027 0.0064 0.0226
Trichomonas vaginalis endoplasmin, putative 0.0048 0.0134 0.2079
Leishmania major heat shock protein 83-1 0.0048 0.0134 0.0472
Schistosoma mansoni tar DNA-binding protein 0.007 0.0206 0.0726
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0027 0.0064 0.0181
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0052 0.0184
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0029 0.0069 0.0194
Mycobacterium tuberculosis Possible two component sensor kinase 0.0048 0.0134 0.0912
Loa Loa (eye worm) RecQ helicase 0.0016 0.0028 0.0079
Loa Loa (eye worm) hypothetical protein 0.0203 0.0643 0.182
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0071
Echinococcus multilocularis multidrug resistance associated protein 7 0.0027 0.0064 0.0219
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0095
Echinococcus multilocularis multidrug resistance associated protein 4 0.0021 0.0043 0.0148
Onchocerca volvulus 0.0071 0.0208 0.6422
Trichomonas vaginalis DNA helicase recq, putative 0.0016 0.0028 0.0432
Echinococcus multilocularis snurportin 1 0.0341 0.1097 0.3742
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0048 0.0134 1
Brugia malayi Probable DNA topoisomerase II 0.0048 0.0134 0.0472
Schistosoma mansoni patched 1 0.0047 0.0129 0.0454

Activities

Activity type Activity value Assay description Source Reference
%max (functional) Antiplasmodial activity as increased heme accumulation after 48 hrs against chloroquine-sensitive Plasmodium falciparum NF54 at 10-100 uM by spectrophotometry ChEMBL. 18025110
Activity (functional) Induction of oxidative stress as lipid peroxide formation after 48 hrs in chloroquine-sensitive Plasmodium falciparum NF54 ChEMBL. 18025110
Activity (functional) Induction of oxidative stress as increased hydroxyl radical formation after 48 hrs in chloroquine-sensitive Plasmodium falciparum NF54 by fast blue BB assay ChEMBL. 18025110
Activity (functional) Induction of oxidative stress as decreased glutathione after 48 hrs in chloroquine-sensitive Plasmodium falciparum NF54 by TCA assay ChEMBL. 18025110
Activity (functional) Induction of oxidative stress as increased H2O2 formation after 48 hrs in chloroquine-sensitive Plasmodium falciparum NF54 by spectrofluorimetry ChEMBL. 18025110
Activity (functional) = 20 % Antiplasmodial activity as reduced parasitaemia at day 4 against multi drug-resistant Plasmodium yoelii infected BALB/c mice (Mus musculus) at 10 mg/kg intraperitoneal dose 6 hrs post infection and daily for 3 days by Giemsa stain ChEMBL. 18025110
Activity (functional) = 30 % Antiplasmodial activity as reduced parasitaemia at day 4 against multi drug-resistant Plasmodium yoelii infected BALB/c mice (Mus musculus) at 25 mg/kg intraperitoneal dose 6 hrs post infection and daily for 3 days by Giemsa stain ChEMBL. 18025110
Activity (functional) = 60 % Antiplasmodial activity as reduced parasitaemia at day 4 against multi drug-resistant Plasmodium yoelii infected BALB/c mice (Mus musculus) at 50 mg/kg intraperitoneal dose 6 hrs post infection and daily for 3 days by Giemsa stain ChEMBL. 18025110
IC50 (functional) = 5 uM Antiplasmodial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum NF54 by [3H]hypoxanthine uptake ChEMBL. 18025110
IC50 (functional) = 11 uM Inhibition of hemozoin formation after 48 hrs in chloroquine-sensitive Plasmodium falciparum NF54 ChEMBL. 18025110
IC50 (functional) = 18 uM Inhibition of hemozoin formation after 48 hrs in multi drug-resistant Plasmodium yoelii ChEMBL. 18025110
IC50 (ADMET) = 1000 uM Cytotoxicity against human MCF7 cells assessed as cell viability after 24 hrs by MTT assay ChEMBL. 18025110

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18025110

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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