TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 493.087 | Formula: C28H37ClN6
H donors: 3 H acceptors: 1 LogP: 4.2 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)nccc2NCCCN1CCN(CC1)CCCN[C@@H]1NCc2c(C1)cccc2
InChi: 1S/C28H37ClN6/c29-24-7-8-25-26(9-12-31-27(25)20-24)30-10-3-13-34-15-17-35(18-16-34)14-4-11-32-28-19-22-5-1-2-6-23(22)21-33-28/h1-2,5-9,12,20,28,32-33H,3-4,10-11,13-19,21H2,(H,30,31)/t28-/m1/s1
InChiKey: LPTCMGDBLJZDIZ-MUUNZHRXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	tubulin gamma chain, putative	0.128253	0.316782	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.00493273	0.00538709	0.014515
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.00493273	0.00538709	0.014515
Loa Loa (eye worm)	hypothetical protein	0.0140356	0.0283728	0.0894459
Brugia malayi	Tubulin beta chain	0.0391166	0.0917045	0.288399
Leishmania major	beta tubulin	0.128253	0.316782	1
Loa Loa (eye worm)	integrin beta-2	0.0331274	0.0765814	0.241648
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0397626	0.0933358	0.289162
Loa Loa (eye worm)	SRC-1	0.00493273	0.00538709	0.0168763
Trichomonas vaginalis	tubulin beta chain, putative	0.0967322	0.237189	0.67069
Echinococcus granulosus	peroxisome assembly protein 26	0.0967322	0.237189	0.748111
Loa Loa (eye worm)	hypothetical protein	0.00582889	0.00764997	0.0240206
Brugia malayi	Tubulin alpha chain	0.032536	0.075088	0.235864
Brugia malayi	sodium-independent organic anion transporter family protein	0.00582889	0.00764997	0.0226526
Giardia lamblia	Alpha-tubulin	0.0967322	0.237189	0.67069
Loa Loa (eye worm)	tubulin beta-2A chain	0.128253	0.316782	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.00353389	0.00185488	0.00333647
Loa Loa (eye worm)	alpha-tubulin	0.0967322	0.237189	0.748714
Trypanosoma cruzi	epsilon tubulin, putative	0.0788792	0.192109	0.5967
Mycobacterium tuberculosis	Cell division protein FtsZ	0.032536	0.075088	0.5
Loa Loa (eye worm)	tubulin beta chain	0.032536	0.075088	0.236933
Loa Loa (eye worm)	hypothetical protein	0.00582889	0.00764997	0.0240206
Echinococcus multilocularis	tubulin delta chain	0.032536	0.075088	0.235101
Echinococcus multilocularis	Tubulin beta 2C chain	0.128253	0.316782	1
Echinococcus multilocularis		0.0048252	0.00511556	0.0136557
Loa Loa (eye worm)	hypothetical protein	0.0641961	0.155033	0.489333
Echinococcus multilocularis	tubulin alpha chain	0.0967322	0.237189	0.748111
Loa Loa (eye worm)	agrin synaptic family protein	0.00376568	0.00244018	0.00757238
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0107907	0.020179	0.0613276
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Trypanosoma brucei	beta tubulin	0.128253	0.316782	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111011	0.0209629	0.0647428
Plasmodium falciparum	histidine-rich protein II	0.398824	1	1
Schistosoma mansoni	tyrosine kinase	0.00493273	0.00538709	0.0170057
Schistosoma mansoni	tyrosine kinase	0.00828756	0.0138583	0.0437473
Loa Loa (eye worm)	tubulin alpha 2	0.0641961	0.155033	0.489333
Trichomonas vaginalis	tubulin alpha chain, putative	0.0391166	0.0917045	0.0687504
Schistosoma mansoni	tubulin subunit delta	0.032536	0.075088	0.237034
Brugia malayi	Tubulin beta chain	0.032536	0.075088	0.235864
Entamoeba histolytica	tubulin alpha chain, putative	0.0967322	0.237189	0.747268
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.128253	0.316782	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0576156	0.138416	0.436871
Loa Loa (eye worm)	tubulin alpha chain	0.0967322	0.237189	0.748714
Trypanosoma brucei	epsilon tubulin	0.0788792	0.192109	0.446089
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0087736	0.0150856	0.0452085
Plasmodium falciparum	tubulin beta chain	0.128253	0.316782	0.261315
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0101286	0.0185071	0.0560366
Trypanosoma brucei	beta tubulin	0.128253	0.316782	1
Echinococcus multilocularis	tubulin subunit TubB	0.0967322	0.237189	0.748111
Leishmania major	beta tubulin	0.128253	0.316782	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.00567968	0.0072732	0.0204841
Plasmodium falciparum	alpha tubulin 2	0.0967322	0.237189	0.175261
Brugia malayi	Kelch motif family protein	0.00497465	0.00549295	0.015833
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0967322	0.237189	0.748714
Echinococcus multilocularis	insulin receptor	0.00537913	0.00651428	0.0180823
Toxoplasma gondii	alpha tubulin TUBA1	0.0967322	0.237189	0.746797
Trypanosoma brucei	epsilon tubulin	0.0716526	0.173861	0.365015
Toxoplasma gondii	beta-1 tubulin, putative	0.128253	0.316782	1
Loa Loa (eye worm)	alpha-tubulin	0.0967322	0.237189	0.748714
Brugia malayi	hypothetical protein	0.00497465	0.00549295	0.015833
Schistosoma mansoni	tubulin subunit alpha	0.032536	0.075088	0.237034
Leishmania major	beta tubulin	0.128253	0.316782	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0159869	0.0332998	0.105001
Echinococcus granulosus	integrin alpha ps	0.00343488	0.00160487	0.00254526
Loa Loa (eye worm)	BEN-1 protein	0.128253	0.316782	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0967322	0.237189	0.67069
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0967322	0.237189	0.67069
Schistosoma mansoni	tubulin subunit alpha	0.0967322	0.237189	0.748747
Treponema pallidum	cell division protein FtsZ	0.032536	0.075088	0.5
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.00376568	0.00244018	0.00618138
Trypanosoma cruzi	alpha tubulin, putative	0.0967322	0.237189	0.74253
Trypanosoma brucei	zeta tubulin	0.106608	0.262126	0.757168
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.00567968	0.0072732	0.0204841
Trypanosoma brucei	beta tubulin	0.128253	0.316782	1
Loa Loa (eye worm)	tubulin alpha chain	0.0967322	0.237189	0.748714
Trypanosoma cruzi	tubulin delta chain	0.0770183	0.18741	0.5815
Schistosoma mansoni	tubulin subunit beta	0.128253	0.316782	1
Brugia malayi	hypothetical protein	0.00582889	0.00764997	0.0226526
Echinococcus granulosus	tubulin alpha	0.0716526	0.173861	0.547693
Trichomonas vaginalis	tubulin alpha chain, putative	0.0391166	0.0917045	0.0687504
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.00493273	0.00538709	0.014515
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0107907	0.020179	0.0613276
Echinococcus multilocularis	tubulin subunit beta	0.128253	0.316782	1
Echinococcus multilocularis	beta tubulin	0.128253	0.316782	1
Schistosoma mansoni	tyrosine kinase	0.0087736	0.0150856	0.0476216
Echinococcus granulosus	Solute carrier organic anion transporter family	0.00582889	0.00764997	0.0216765
Trypanosoma brucei	zeta tubulin, putative	0.106608	0.262126	0.757168
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0967322	0.237189	0.748111
Brugia malayi	protein-tyrosine kinase	0.0042421	0.00364318	0.00998479
Schistosoma mansoni	tubulin subunit alpha	0.0967322	0.237189	0.748747
Schistosoma mansoni	tubulin subunit beta	0.128253	0.316782	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0133168	0.0265576	0.0824307
Schistosoma mansoni	tubulin subunit beta	0.128253	0.316782	1
Schistosoma mansoni	alpha tubulin	0.0967322	0.237189	0.748747
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Echinococcus multilocularis	tubulin alpha	0.0716526	0.173861	0.547693
Echinococcus multilocularis	Tubulin beta 2C chain	0.128253	0.316782	1
Echinococcus granulosus	integrin beta 2	0.0246413	0.055153	0.172011
Schistosoma mansoni	integrin alpha-ps	0.00373099	0.00235258	0.00742651
Loa Loa (eye worm)	hypothetical protein	0.00582889	0.00764997	0.0240206
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00493273	0.00538709	0.014515
Trypanosoma brucei	beta tubulin	0.128253	0.316782	1
Toxoplasma gondii	beta tubulin	0.128253	0.316782	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0967322	0.237189	0.748111
Loa Loa (eye worm)	hypothetical protein	0.00376568	0.00244018	0.00757238
Trichomonas vaginalis	tubulin gamma chain, putative	0.0788792	0.192109	0.48417
Echinococcus multilocularis	expressed protein	0.00376568	0.00244018	0.00518877
Leishmania major	beta tubulin	0.128253	0.316782	1
Loa Loa (eye worm)	hypothetical protein	0.0967322	0.237189	0.748714
Echinococcus granulosus	tyrosine protein kinase Lyn	0.00493273	0.00538709	0.014515
Echinococcus granulosus	tyrosine protein kinase Src42A	0.00375606	0.00241589	0.00511191
Schistosoma mansoni	integrin alpha	0.0174705	0.0370462	0.116945
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0770183	0.18741	0.588436
Trypanosoma brucei	alpha tubulin	0.0967322	0.237189	0.646378
Loa Loa (eye worm)	hypothetical protein	0.00376568	0.00244018	0.00757238
Trypanosoma cruzi	beta tubulin, putative	0.128253	0.316782	1
Schistosoma mansoni	tubulin subunit beta	0.128253	0.316782	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.032536	0.075088	0.5
Brugia malayi	Protein kinase domain containing protein	0.00537913	0.00651428	0.019062
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.00299139	0.000485026	0.00139966
Plasmodium vivax	tubulin alpha chain, putative	0.0967322	0.237189	0.67069
Trichomonas vaginalis	tubulin beta chain, putative	0.0967322	0.237189	0.67069
Loa Loa (eye worm)	TK/INSR protein kinase	0.00537913	0.00651428	0.020435
Echinococcus multilocularis	tubulin alpha 1C chain	0.0967322	0.237189	0.748111
Leishmania major	beta tubulin	0.128253	0.316782	1
Echinococcus multilocularis	integrin alpha 3	0.0137395	0.0276251	0.0848926
Brugia malayi	alpha-tubulin	0.0967322	0.237189	0.748362
Brugia malayi	beta-tubulin, identical	0.128253	0.316782	1
Giardia lamblia	Gamma tubulin	0.0789979	0.192409	0.48541
Loa Loa (eye worm)	hypothetical protein	0.00582889	0.00764997	0.0240206
Echinococcus granulosus	tubulin alpha chain	0.0967322	0.237189	0.748111
Leishmania major	beta tubulin	0.128253	0.316782	1
Leishmania major	zeta tubulin, putative	0.106608	0.262126	0.577528
Echinococcus multilocularis	tubulin alpha 3 chain	0.0967322	0.237189	0.748111
Schistosoma mansoni	alpha tubulin	0.0967322	0.237189	0.748747
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.00582889	0.00764997	0.0216765
Echinococcus multilocularis	tubulin alpha chain	0.0967322	0.237189	0.748111
Trichomonas vaginalis	tubulin beta chain, putative	0.0967322	0.237189	0.67069
Brugia malayi	Furin-like cysteine rich region family protein	0.0159869	0.0332998	0.103747
Echinococcus multilocularis	integrin beta 2	0.0246413	0.055153	0.172011
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00493273	0.00538709	0.014515
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Loa Loa (eye worm)	hypothetical protein	0.00582889	0.00764997	0.0240206
Leishmania major	beta tubulin	0.128253	0.316782	1
Leishmania major	beta tubulin	0.128253	0.316782	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0967322	0.237189	0.67069
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042421	0.00364318	0.00899598
Echinococcus granulosus	epidermal growth factor receptor	0.0159869	0.0332998	0.102852
Loa Loa (eye worm)	tubulin beta chain	0.128253	0.316782	1
Schistosoma mansoni	tyrosine kinase	0.00537913	0.00651428	0.0205639
Echinococcus granulosus	tubulin alpha 3 chain	0.0967322	0.237189	0.748111
Loa Loa (eye worm)	hypothetical protein	0.00872975	0.0149749	0.0471467
Schistosoma mansoni	tyrosine kinase	0.00493273	0.00538709	0.0170057
Echinococcus granulosus	tubulin alpha chain	0.0967322	0.237189	0.748111
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.00376568	0.00244018	0.00618138
Brugia malayi	Integrin beta pat-3 precursor	0.0331274	0.0765814	0.240586
Loa Loa (eye worm)	hypothetical protein	0.00582889	0.00764997	0.0240206
Onchocerca volvulus		0.00582889	0.00764997	0.0583637
Echinococcus multilocularis	integrin alpha ps	0.00716587	0.011026	0.0323607
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0042421	0.00364318	0.00899598
Loa Loa (eye worm)	tubulin gamma chain	0.0789979	0.192409	0.607334
Trichomonas vaginalis	tubulin beta chain, putative	0.0967322	0.237189	0.67069
Onchocerca volvulus		0.00582889	0.00764997	0.0583637
Leishmania major	beta tubulin	0.128253	0.316782	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.00493273	0.00538709	0.014515
Echinococcus multilocularis	tubulin alpha chain	0.0967322	0.237189	0.748111
Brugia malayi	Tubulin beta-1 chain	0.128253	0.316782	1
Leishmania major	beta tubulin	0.128253	0.316782	1
Schistosoma mansoni	hypothetical protein	0.00343488	0.00160487	0.00506618
Schistosoma mansoni	tubulin subunit beta	0.128253	0.316782	1
Leishmania major	beta tubulin	0.128253	0.316782	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0967322	0.237189	0.748111
Echinococcus granulosus	alpha tubulin	0.0967322	0.237189	0.748111
Echinococcus multilocularis	tubulin gamma 1 chain	0.0789979	0.192409	0.606391
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Schistosoma mansoni	tyrosine kinase	0.0087736	0.0150856	0.0476216
Schistosoma mansoni	tubulin subunit alpha	0.0967322	0.237189	0.748747
Trichomonas vaginalis	tubulin beta chain, putative	0.0391166	0.0917045	0.0687504
Loa Loa (eye worm)	TK protein kinase	0.0111011	0.0209629	0.0660518
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Echinococcus multilocularis	tubulin epsilon chain	0.0788792	0.192109	0.605442
Echinococcus granulosus	tubulin subunit TubB	0.0967322	0.237189	0.748111
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00493273	0.00538709	0.014515
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.00376568	0.00244018	0.00618138
Echinococcus multilocularis	Tubulin beta 2C chain	0.128253	0.316782	1
Plasmodium vivax	tubulin beta chain, putative	0.128253	0.316782	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0227547	0.0503893	0.158956
Brugia malayi	tubulin alpha-2 chain	0.0967322	0.237189	0.748362
Schistosoma mansoni	tyrosine kinase	0.0220465	0.048601	0.153421
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0391166	0.0917045	0.0687504
Trypanosoma brucei	epsilon tubulin	0.0788792	0.192109	0.446089
Echinococcus granulosus	tubulin alpha 3 chain	0.0967322	0.237189	0.748111
Plasmodium vivax	tubulin alpha chain, putative	0.0967322	0.237189	0.67069
Brugia malayi	Tubulin gamma chain	0.0789979	0.192409	0.606784
Echinococcus multilocularis	integrin alpha ps	0.00343488	0.00160487	0.00254526
Schistosoma mansoni	follistatin	0.00376568	0.00244018	0.00770302
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.00493273	0.00538709	0.014515
Brugia malayi	Tubulin alpha chain	0.0967322	0.237189	0.748362
Brugia malayi	Tubulin alpha-2 chain	0.0967322	0.237189	0.748362
Leishmania major	beta tubulin	0.128253	0.316782	1
Echinococcus multilocularis	integrin alpha ps	0.00716587	0.011026	0.0323607
Echinococcus granulosus	tyrosine kinase	0.0042421	0.00364318	0.00899598
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.00376568	0.00244018	0.00757238
Echinococcus granulosus	Tubulin beta 2C chain	0.128253	0.316782	1
Brugia malayi	tubulin alpha chain - mouse	0.0967322	0.237189	0.748362
Trichomonas vaginalis	tubulin beta chain, putative	0.0967322	0.237189	0.67069
Giardia lamblia	Beta tubulin	0.128253	0.316782	1
Echinococcus multilocularis	hypothetical protein	0.0967322	0.237189	0.748111
Echinococcus granulosus	tubulin alpha chain	0.0967322	0.237189	0.748111
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0716526	0.173861	0.545333
Schistosoma mansoni	tyrosine kinase	0.0159869	0.0332998	0.105119
Onchocerca volvulus	Putative organic anion transporter	0.00582889	0.00764997	0.0583637
Schistosoma mansoni	tyrosine kinase	0.00537913	0.00651428	0.0205639
Echinococcus granulosus	tubulin alpha 1C chain	0.0967322	0.237189	0.748111
Schistosoma mansoni	tyrosine kinase	0.00828756	0.0138583	0.0437473
Echinococcus multilocularis	epidermal growth factor receptor	0.0159869	0.0332998	0.102852
Echinococcus granulosus	tyrosine protein kinase Fyn	0.00493273	0.00538709	0.014515
Onchocerca volvulus		0.00582889	0.00764997	0.0583637
Leishmania major	beta tubulin	0.128253	0.316782	1
Schistosoma mansoni	tubulin subunit beta	0.032536	0.075088	0.237034
Brugia malayi	hypothetical protein	0.00582889	0.00764997	0.0226526
Leishmania major	gamma-tubulin	0.0789979	0.192409	0.0386377
Echinococcus granulosus	tubulin delta chain	0.032536	0.075088	0.235101
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0967322	0.237189	0.67069
Trypanosoma brucei	tubulin delta chain	0.0770183	0.18741	0.425212
Schistosoma mansoni	tubulin subunit beta	0.128253	0.316782	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0967322	0.237189	0.748111
Echinococcus granulosus	Tubulin alpha 1 chain	0.0967322	0.237189	0.748111
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Schistosoma mansoni	tubulin subunit epsilon	0.0788792	0.192109	0.606439
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0227547	0.0503893	0.156936
Trichomonas vaginalis	tubulin beta chain, putative	0.128253	0.316782	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.128253	0.316782	1
Loa Loa (eye worm)	hypothetical protein	0.00343488	0.00160487	0.0049352
Echinococcus granulosus	agrin	0.00376568	0.00244018	0.00518877
Brugia malayi	sodium-independent organic anion transporter family protein	0.00582889	0.00764997	0.0226526
Brugia malayi	Tyrosine-protein kinase abl-1	0.0101286	0.0185071	0.0569785
Echinococcus granulosus	tubulin gamma 1 chain	0.0789979	0.192409	0.606391
Echinococcus multilocularis	follistatin	0.00376568	0.00244018	0.00518877
Entamoeba histolytica	tubulin gamma chain	0.0789979	0.192409	0.605073
Brugia malayi	Integrin alpha pat-2 precursor	0.0174705	0.0370462	0.115591
Loa Loa (eye worm)	BEN-1 protein	0.128253	0.316782	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.128253	0.316782	1
Mycobacterium leprae	cell division protein FtsZ	0.032536	0.075088	0.5
Brugia malayi	Cell division protein ftsZ	0.032536	0.075088	0.235864
Plasmodium falciparum	tubulin epsilon chain, putative	0.0788792	0.192109	0.126521
Entamoeba histolytica	tubulin family protein	0.128253	0.316782	1
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Trypanosoma cruzi	tubulin delta chain	0.0770183	0.18741	0.5815
Trypanosoma brucei	alpha tubulin	0.0967322	0.237189	0.646378
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0120908	0.0234619	0.0726433
Echinococcus multilocularis	agrin	0.00376568	0.00244018	0.00518877
Trypanosoma cruzi	zeta tubulin, putative	0.106608	0.262126	0.823196
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0107907	0.020179	0.0613276
Loa Loa (eye worm)	hypothetical protein	0.0103046	0.0189517	0.0597019
Schistosoma mansoni	integrin alpha-ps	0.00716587	0.011026	0.0348063
Schistosoma mansoni	agrin	0.00376568	0.00244018	0.00770302
Echinococcus multilocularis	Tubulin beta 2C chain	0.128253	0.316782	1
Leishmania major	beta tubulin	0.128253	0.316782	1
Schistosoma mansoni	alpha tubulin	0.0967322	0.237189	0.748747
Onchocerca volvulus	Putative organic anion transporter	0.00582889	0.00764997	0.0583637
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0641961	0.155033	0.33077
Schistosoma mansoni	tubulin subunit gamma	0.0789979	0.192409	0.607386
Trichomonas vaginalis	tubulin, putative	0.0391166	0.0917045	0.0687504
Toxoplasma gondii	transporter, major facilitator family protein	0.00582889	0.00764997	0.0165737
Trichomonas vaginalis	tubulin epsilon chain, putative	0.128253	0.316782	1
Echinococcus granulosus	tubulin epsilon chain	0.0788792	0.192109	0.605442
Trichomonas vaginalis	tubulin, putative	0.128253	0.316782	1
Toxoplasma gondii	beta-tubulin, putative	0.128253	0.316782	1
Leishmania major	beta tubulin	0.128253	0.316782	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.128253	0.316782	1
Schistosoma mansoni	tyrosine kinase	0.0107907	0.020179	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0576156	0.138416	0.436871
Echinococcus granulosus	follistatin	0.00376568	0.00244018	0.00518877
Trypanosoma cruzi	tubulin gamma chain	0.0789979	0.192409	0.59767
Trichomonas vaginalis	tubulin alpha chain, putative	0.0716526	0.173861	0.408671
Loa Loa (eye worm)	hypothetical protein	0.00376568	0.00244018	0.00757238
Leishmania major	beta tubulin	0.128253	0.316782	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0576156	0.138416	0.262019
Loa Loa (eye worm)	tubulin alpha 2	0.0250796	0.0562598	0.17749
Loa Loa (eye worm)	tubulin beta-4 chain	0.128253	0.316782	1
Schistosoma mansoni	tyrosine kinase	0.00828756	0.0138583	0.0437473
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.00497465	0.00549295	0.0172105
Echinococcus granulosus	Tubulin beta 2C chain	0.128253	0.316782	1
Echinococcus granulosus	insulin receptor	0.00537913	0.00651428	0.0180823
Loa Loa (eye worm)	hypothetical protein	0.00582889	0.00764997	0.0240206
Echinococcus granulosus	tyrosine protein kinase Blk	0.0042421	0.00364318	0.00899598
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Trichomonas vaginalis	tubulin alpha chain, putative	0.0391166	0.0917045	0.0687504
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.00493273	0.00538709	0.014515
Schistosoma mansoni	organic anion transporter	0.00582889	0.00764997	0.024149
Echinococcus granulosus	Tubulin beta 2C chain	0.128253	0.316782	1
Schistosoma mansoni	organic anion transporter	0.00582889	0.00764997	0.024149
Echinococcus multilocularis	peroxisome assembly protein 26	0.0967322	0.237189	0.748111
Echinococcus granulosus	tubulin subunit beta	0.128253	0.316782	1
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.00582889	0.00764997	0.0240206
Brugia malayi	Tubulin alpha-2 chain	0.0967322	0.237189	0.748362
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0042421	0.00364318	0.00899598
Echinococcus granulosus	epidermal growth factor receptor	0.0087736	0.0150856	0.0452085
Trypanosoma cruzi	zeta tubulin, putative	0.106608	0.262126	0.823196
Mycobacterium ulcerans	cell division protein FtsZ	0.032536	0.075088	0.5
Echinococcus multilocularis	tubulin beta 1 chain	0.128253	0.316782	1
Echinococcus granulosus	tubulin beta 1 chain	0.128253	0.316782	1
Leishmania major	beta tubulin	0.128253	0.316782	1
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Plasmodium falciparum	histidine-rich protein III	0.398824	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0789979	0.192409	0.48541
Giardia lamblia	Beta tubulin	0.128253	0.316782	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0967322	0.237189	0.748111
Onchocerca volvulus		0.0391166	0.0917045	1
Echinococcus multilocularis	tubulin alpha chain	0.0967322	0.237189	0.748111
Echinococcus multilocularis	epidermal growth factor receptor	0.0087736	0.0150856	0.0452085
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0967322	0.237189	0.748111
Loa Loa (eye worm)	TK protein kinase	0.00353389	0.00185488	0.00572452
Loa Loa (eye worm)	beta-tubulin	0.128253	0.316782	1
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.00582889	0.00764997	0.0216765
Leishmania major	epsilon tubulin, putative	0.0788792	0.192109	0.0363211
Onchocerca volvulus	Putative organic anion transporter	0.00582889	0.00764997	0.0583637
Leishmania major	beta tubulin	0.128253	0.316782	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.00493273	0.00538709	0.014515
Trypanosoma brucei	alpha tubulin	0.0967322	0.237189	0.646378
Echinococcus multilocularis	beta tubulin	0.128253	0.316782	1
Brugia malayi	SRC-1	0.00493273	0.00538709	0.0154983
Brugia malayi	prostaglandin transporter	0.00582889	0.00764997	0.0226526
Trypanosoma brucei	tubulin gamma chain	0.0789979	0.192409	0.44742
Plasmodium vivax	tubulin gamma chain, putative	0.0789979	0.192409	0.48541
Schistosoma mansoni	cell adhesion molecule	0.00280591	0.0000166557	0.0000525778
Trypanosoma brucei	beta tubulin	0.0716526	0.173861	0.365015
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.00493273	0.00538709	0.014515
Echinococcus granulosus	tyrosine protein kinase Src64B	0.00493273	0.00538709	0.014515
Trichomonas vaginalis	tubulin alpha chain, putative	0.128253	0.316782	1
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Loa Loa (eye worm)	integrin alpha pat-2	0.0261264	0.0589032	0.185835
Loa Loa (eye worm)	tubulin alpha 2	0.0641961	0.155033	0.489333
Leishmania major	alpha tubulin	0.0967322	0.237189	0.384779
Echinococcus granulosus	tyrosine protein kinase Src42A	0.00493273	0.00538709	0.014515
Loa Loa (eye worm)	TK protein kinase	0.0042421	0.00364318	0.0113705
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0227547	0.0503893	0.156936
Brugia malayi	sodium-independent organic anion transporter family protein	0.00582889	0.00764997	0.0226526
Plasmodium vivax	tubulin epsilon chain, putative	0.0788792	0.192109	0.48417
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0641961	0.155033	0.489333
Echinococcus multilocularis	tubulin alpha chain	0.0967322	0.237189	0.748111
Plasmodium falciparum	tubulin gamma chain	0.0789979	0.192409	0.126845
Brugia malayi	SPARC precursor	0.00376568	0.00244018	0.00618138
Toxoplasma gondii	alpha-tubulin I, putative	0.0967322	0.237189	0.746797
Echinococcus granulosus	tubulin alpha chain	0.0967322	0.237189	0.748111
Loa Loa (eye worm)	hypothetical protein	0.0120908	0.0234619	0.0739413
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.00582889	0.00764997	0.0216765
Toxoplasma gondii	tubulin, putative	0.00722659	0.0111793	0.0278014
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0042421	0.00364318	0.00899598
Brugia malayi	secreted modular calcium-binding protein 1	0.00376568	0.00244018	0.00618138
Loa Loa (eye worm)	hypothetical protein	0.00376568	0.00244018	0.00757238
Schistosoma mansoni	integrin beta subunit	0.0196666	0.0425915	0.134451
Echinococcus granulosus	tubulin alpha chain	0.0967322	0.237189	0.748111
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.00493273	0.00538709	0.014515
Echinococcus granulosus	beta tubulin	0.128253	0.316782	1
Echinococcus granulosus	beta tubulin	0.128253	0.316782	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.00493273	0.00538709	0.014515
Giardia lamblia	Alpha-tubulin	0.0967322	0.237189	0.67069
Giardia lamblia	Epsilon tubulin	0.0397626	0.0933358	0.0754998
Echinococcus granulosus	Tubulin beta 2C chain	0.128253	0.316782	1
Trichomonas vaginalis	tubulin, putative	0.0398813	0.0936355	0.0767398
Trypanosoma brucei	alpha tubulin	0.0967322	0.237189	0.646378
Trypanosoma cruzi	epsilon tubulin, putative	0.0788792	0.192109	0.5967
Echinococcus multilocularis	Tubulin beta 2C chain	0.128253	0.316782	1
Loa Loa (eye worm)	hypothetical protein	0.00373099	0.00235258	0.00729583
Echinococcus granulosus	tyrosine protein kinase HCK	0.00353389	0.00185488	0.00333647
Echinococcus granulosus	Tubulin alpha 1 chain	0.0967322	0.237189	0.748111
Echinococcus granulosus	integrin alpha ps	0.00716587	0.011026	0.0323607
Echinococcus granulosus	integrin alpha 3	0.0137395	0.0276251	0.0848926
Giardia lamblia	Beta tubulin	0.128253	0.316782	1
Onchocerca volvulus		0.00582889	0.00764997	0.0583637
Entamoeba histolytica	tubulin family protein	0.128253	0.316782	1
Plasmodium falciparum	alpha tubulin 1	0.0967322	0.237189	0.175261
Echinococcus granulosus	Tubulin beta 2C chain	0.128253	0.316782	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0107907	0.020179	0.0613276
Entamoeba histolytica	tubulin alpha-1 chain	0.0967322	0.237189	0.747268
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.00376568	0.00244018	0.00618138
Echinococcus multilocularis	tubulin alpha 1C chain	0.0967322	0.237189	0.748111
Loa Loa (eye worm)	hypothetical protein	0.00497465	0.00549295	0.0172105
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.00375606	0.00241589	0.00511191
Onchocerca volvulus		0.00582889	0.00764997	0.0583637
Trichomonas vaginalis	tubulin, putative	0.0391166	0.0917045	0.0687504

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (functional)	= 4 uM	Cytotoxicity was tested on human diploid embryonic lung cell line (MRC-5) (in vitro)	ChEMBL.	12570376
IC50 (functional)	= 19 nM	Antimalarial activity was determined by its inhibition of Plasmodium falciparum FcB1 strain (in vitro)	ChEMBL.	12570376

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	12570376

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2111259

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1693548