pI: 7.3605 |
Length (AA): 92 |
MW (Da): 10051 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 79 | 1th7 (A) | 7 | 76 | 36.00 | 0.00000093 | 1 | 1.23 | -0.77 |
13 | 80 | 1h64 (1) | 3 | 72 | 34.00 | 0 | 1 | 1.29 | -1.42 |
18 | 79 | 1i4k (A) | 9 | 71 | 37.00 | 0.0000035 | 1 | 1.28 | -1.6 |
3 | 79 | 1th7 (A) | 7 | 76 | 36.00 | 0.0000039 | 0.92 | 0.994256 | 1.52 |
12 | 80 | 1i4k (A) | 3 | 72 | 33.00 | 0 | 1 | 1.1971 | -0.41 |
12 | 80 | 1mgq (A) | 12 | 81 | 36.00 | 0 | 1 | 1.2101 | -0.24 |
14 | 85 | 4c92 (G) | 26 | 109 | 35.00 | 0 | 1 | 1.17071 | 0.28 |
16 | 81 | 3swn (C) | 26 | 99 | 38.00 | 0.0000000000064 | 1 | 1.15249 | 0.01 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_128343)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G03870 | U6 snRNA-associated Sm-like protein LSm7 |
Babesia bovis | BBOV_III001070 | LSM domain containing protein |
Brugia malayi | Bm1_31505 | U6 snRNA-associated Sm-like protein LSm7 |
Caenorhabditis elegans | CELE_ZK593.7 | Protein LSM-7 |
Cryptosporidium parvum | cgd7_3520 | hypothetical protein |
Dictyostelium discoideum | DDB_G0289499 | LSM domain-containing protein |
Drosophila melanogaster | Dmel_CG13277 | CG13277 gene product from transcript CG13277-RC |
Entamoeba histolytica | EHI_025840 | LSM domain containing protein |
Homo sapiens | ENSG00000130332 | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
Leishmania braziliensis | LbrM.26.0020 | Lsm7p protein, putative |
Leishmania donovani | LdBPK_260010.1 | Lsm7p protein, putative |
Leishmania infantum | LinJ.26.0010 | Lsm7p protein, putative |
Leishmania major | LmjF.26.0005 | Lsm7p protein, putative |
Leishmania mexicana | LmxM.26.0005 | Lsm7p protein, putative |
Loa Loa (eye worm) | LOAG_01816 | hypothetical protein |
Mus musculus | ENSMUSG00000035215 | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
Neospora caninum | NCLIV_014070 | u6 snRNA-associated Sm-like protein, putative |
Oryza sativa | 4344803 | Os08g0177700 |
Plasmodium berghei | PBANKA_0607600 | U6 snRNA-associated Sm-like protein LSm7, putative |
Plasmodium falciparum | PF3D7_1209200 | U6 snRNA-associated Sm-like protein LSm7, putative |
Plasmodium knowlesi | PKNH_1309100 | U6 snRNA-associated Sm-like protein LSm7, putative |
Plasmodium vivax | PVX_084490 | U6 snRNA-associated Sm-like protein LSm7, putative |
Plasmodium yoelii | PY03614 | u6 snRNA-associated sm-like protein lsm7 |
Saccharomyces cerevisiae | YNL147W | Sm-like protein LSM7 |
Schmidtea mediterranea | mk4.002749.00 | |
Trypanosoma brucei gambiense | Tbg972.5.5570 | U6 snRNA-associated Sm-like protein LSm7p |
Trypanosoma brucei | Tb927.5.4030 | U6 snRNA-associated Sm-like protein LSm7p |
Trypanosoma congolense | TcIL3000_5_4560 | U6 snRNA-associated Sm-like protein LSm7p, putative |
Trypanosoma cruzi | TcCLB.506855.209 | U6 snRNA-associated Sm-like protein LSm7p |
Trypanosoma cruzi | TcCLB.503479.49 | U6 snRNA-associated Sm-like protein LSm7p |
Toxoplasma gondii | TGME49_286560 | U6 snRNA-associated Sm family protein |
Theileria parva | TP03_0732 | U6 snRNA-associated protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.4030 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.4030 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.4030 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.5.4030 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_ZK593.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK593.7 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_ZK593.7 | Caenorhabditis elegans | slow growth | wormbase |
CELE_ZK593.7 | Caenorhabditis elegans | sterile | wormbase |
YNL147W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_286560 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.