Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1332 | 0.8141 |
Echinococcus multilocularis | Multi antimicrobial extrusion protein MatE | 0.0068 | 0.3221 | 0.3221 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.1848 | 0.1848 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 1 | 1 |
Echinococcus granulosus | multidrug and toxin extrusion protein 2 | 0.0074 | 0.3594 | 0.3594 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0024 | 0.0702 | 0.0702 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0702 | 0.0702 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.3594 | 0.5 |
Brugia malayi | Doublecortin family protein | 0.0024 | 0.0702 | 0.4289 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.3594 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.3594 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.1848 | 0.1848 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0037 | 0.1485 | 0.5 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0702 | 0.0702 |
Echinococcus granulosus | RUN | 0.0024 | 0.0702 | 0.0702 |
Trypanosoma brucei | membrane transporter protein, putative | 0.0074 | 0.3594 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.3594 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0024 | 0.0702 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.004 | 0.1636 | 0.1636 |
Schistosoma mansoni | loxhd1 | 0.0024 | 0.0702 | 0.0702 |
Schistosoma mansoni | multidrug resistance protein | 0.0074 | 0.3594 | 0.3594 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.3594 | 0.5 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0024 | 0.0702 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.004 | 0.1636 | 1 |
Trypanosoma brucei | MATE efflux family protein, putative | 0.0074 | 0.3594 | 0.5 |
Schistosoma mansoni | polycystin 1-related | 0.0024 | 0.0702 | 0.0702 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0702 | 0.0702 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0702 | 0.0702 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.7523 | 0.7523 |
Loa Loa (eye worm) | doublecortin family protein | 0.0024 | 0.0702 | 0.4289 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.3594 | 0.5 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0024 | 0.0702 | 0.0702 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0702 | 0.4289 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.7523 | 0.7523 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0702 | 0.4289 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0702 | 0.4289 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0702 | 0.0702 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0702 | 0.0702 |
Echinococcus multilocularis | multidrug and toxin extrusion protein 2 | 0.0074 | 0.3594 | 0.3594 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.5059 | 0.5059 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0702 | 0.4289 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.004 | 0.1636 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0702 | 0.0702 |
Trypanosoma cruzi | membrane transporter protein, putative | 0.0074 | 0.3594 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0037 | 0.1485 | 0.5 |
Echinococcus multilocularis | RUN | 0.0024 | 0.0702 | 0.0702 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.004 | 0.1636 | 0.1636 |
Trypanosoma brucei | membrane transporter protein, putative | 0.0074 | 0.3594 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.0702 | 0.5 | |
Trypanosoma brucei | membrane transporter protein, putative | 0.0074 | 0.3594 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.7523 | 0.7523 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.3594 | 0.5 |
Echinococcus multilocularis | geminin | 0.0185 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0.0702 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.2 uM | Inhibitory activity against 5-lipoxygenase. | ChEMBL. | No reference |
IC50 (binding) | = 8.2 uM | Inhibitory activity against 5-lipoxygenase. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.