Detailed view for PF3D7_1201800

Basic information

TDR Targets ID: 5066
Plasmodium falciparum, cytochrome c oxidase assembly protein COX19, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.5828 | Length (AA): 218 | MW (Da): 26160 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06747   CHCH domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 211 4u0r (A) 226 473 29.00 0.14 0.05 0.953103 0.8
22 203 4uos (A) 0 183 10.00 0.000064 0.01 1.01296 -1.2
24 55 1u96 (A) 26 57 25.00 0.91 0.3 0.435689 -0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 32 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 48 hs, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 40 hs, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 16 hs, Male Gametocyte. Otto TD Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_129033)

Species Accession Gene Product
Arabidopsis thaliana AT1G66590   cytochrome c oxidase 19-1
Arabidopsis thaliana AT1G69750   cytochrome c oxidase 19-2
Babesia bovis BBOV_IV008710   hypothetical protein
Babesia bovis BBOV_IV008720   hypothetical protein
Brugia malayi Bm1_24410   CHCH domain containing protein
Candida albicans CaO19.4967   Cytochrome oxidase
Candida albicans CaO19.12432   cytochrome oxidase
Caenorhabditis elegans CELE_F45H11.5   Protein F45H11.5
Dictyostelium discoideum DDB_G0288903   hypothetical protein
Drosophila melanogaster Dmel_CG42496   CG42496 gene product from transcript CG42496-RB
Homo sapiens 90639   COX19 cytochrome c oxidase assembly factor
Leishmania braziliensis LbrM.19.1380   hypothetical protein, conserved
Leishmania donovani LdBPK_191180.1   CHCH domain containing protein, putative
Leishmania infantum LinJ.19.1180   hypothetical protein, conserved
Leishmania major LmjF.19.1190   hypothetical protein, conserved
Leishmania mexicana LmxM.19.1190   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05188   CHCH domain-containing protein
Mus musculus 68033   cytochrome c oxidase assembly protein 19
Neospora caninum NCLIV_008520   hypothetical protein
Oryza sativa 4329136   Os02g0313500
Onchocerca volvulus OVOC240  
Plasmodium berghei PBANKA_0600800   cytochrome c oxidase assembly protein COX19, putative
Plasmodium falciparum PF3D7_1201800   cytochrome c oxidase assembly protein COX19, putative
Plasmodium knowlesi PKNH_1301700   cytochrome c oxidase assembly protein COX19, putative
Plasmodium vivax PVX_084115   cytochrome c oxidase assembly protein COX19, putative
Plasmodium yoelii PY04195   protein Saccharomyces cerevisiae YLL018c-a-related
Saccharomyces cerevisiae YLL018C-A   Cox19p
Schmidtea mediterranea mk4.014209.01  
Trypanosoma brucei gambiense Tbg972.10.19380   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.10.19340   hypothetical protein, unlikely
Trypanosoma brucei Tb927.10.15790   CHCH domain containing protein, putative
Trypanosoma congolense TcIL3000_10_13600   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511361.50   CHCH domain containing protein, putative
Trypanosoma cruzi TcCLB.508899.100   CHCH domain containing protein, putative
Toxoplasma gondii TGME49_254260   COX19 cytochrome c oxidase assembly family protein
Theileria parva TP01_0902   hypothetical protein

Essentiality

PF3D7_1201800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.15790 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.15790 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.15790 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.15790 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0600800 Plasmodium berghei Essential plasmo
TGME49_254260 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1201800 (Plasmodium falciparum), cytochrome c oxidase assembly protein COX19, putative
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