Detailed view for Rv2711

Basic information

TDR Targets ID: 6244
Mycobacterium tuberculosis, Iron-dependent repressor and activator IdeR
Source Database / ID:  Tuberculist 

pI: 5.046 | Length (AA): 230 | MW (Da): 25233 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01325   Iron dependent repressor, N-terminal DNA binding domain
PF02742   Iron dependent repressor, metal binding and dimerisation domain
PF04023   FeoA domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0046983   protein dimerization activity  
GO:0046914   transition metal ion binding  
GO:0005506   iron ion binding  
GO:0003700   transcription factor activity  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 72 2wte (A) 137 208 22.00 0 0.92 0.765743 -1.95
1 230 1fx7 (A) 1 230 99.99 0 1 2.2688 -1.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1B1B:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1FX7:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1U8R:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2FVH:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2ISY:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2ISZ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2IT0:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_132027)

Species Accession Gene Product
Escherichia coli b0817   Mn(2+)-responsive manganese regulon transcriptional regulator
Mycobacterium leprae ML1013c   IRON-DEPENDENT REPRESSOR AND ACTIVATOR IDER
Mycobacterium tuberculosis Rv2711   Iron-dependent repressor and activator IdeR
Mycobacterium tuberculosis Rv2788   Probable transcriptional repressor SirR
Mycobacterium ulcerans MUL_2145   transcriptional repressor SirR
Mycobacterium ulcerans MUL_3351   iron-dependent repressor and activator IdeR
Treponema pallidum TP0167   cation-activated repressor protein (troR)

Essentiality

Rv2711 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0817 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
response to drug (GO:0042493) decreased sensitivity toward (PATO:0001550) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium tuberculosis 5089   216208  
Annotator: crowther@u.washington.edu. Comment: 2007-12-05. References: 10645447
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-11. References: 12065475
response to drug (GO:0042493) increased sensitivity toward (PATO:0001549) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium smegmatis 205696  
Annotator: crowther@u.washington.edu. Comment: 2007-12-11. References: 8939436

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium leprae IRON-DEPENDENT REPRESSOR AND ACTIVATOR IDER Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1841 0.6792 0.6791
0.1805 0.6791 0.6791
0.2245 0.6798 0.6797
0.1821 0.6796 0.6793
0.1805 0.679 0.679
0.1821 0.6796 0.6793
0.1877 0.6724 0.6724
0.1841 0.6792 0.6791
0.1958 0.6794 0.6792
0.1974 0.6724 0.6724
0.2191 0.6783 0.6782
0.2245 0.5181 0.6661
0.1878 0.6792 0.6791
0.1821 0.6796 0.6793
0.1841 0.6792 0.6791
0.1841 0.6791 0.6791
0.2245 0.5181 0.6661
0.1877 0.6724 0.6724
0.1821 0.6796 0.6793
0.2245 0.5181 0.6661
0.1893 0.6763 0.6724
0.1918 0.6791 0.6791

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

3 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Rv2711 (Mycobacterium tuberculosis), Iron-dependent repressor and activator IdeR
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