Detailed information for compound 1508788

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 415.146 | Formula: C14H13Br2N3S
  • H donors: 2 H acceptors: 0 LogP: 4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)Nc1cccc(c1)SCc1cc(Br)cc(c1)Br
  • InChi: 1S/C14H13Br2N3S/c15-10-4-9(5-11(16)6-10)8-20-13-3-1-2-12(7-13)19-14(17)18/h1-7H,8H2,(H4,17,18,19)
  • InChiKey: UUGXNUUNPUVLGL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lysine specific histone demethylase 1A 0.0095 0.0289 0.2063
Loa Loa (eye worm) hypothetical protein 0.0059 0.0156 0.1288
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0018 0.0006 0.0146
Mycobacterium tuberculosis Probable cytochrome C oxidase (subunit III) CtaE 0.0072 0.0206 0.0203
Loa Loa (eye worm) beta-lactamase 0.0043 0.0098 0.0807
Schistosoma mansoni hypothetical protein 0.0036 0.0075 0.0619
Trypanosoma brucei pteridine reductase 1 0.0025 0.0035 0.081
Brugia malayi Animal haem peroxidase family protein 0.004 0.0088 0.0724
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 1 0.0079 0.023 0.1534
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0133 0.0427 0.3266
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0807
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0044 0.0102 0.0527
Trichomonas vaginalis glutaminase, putative 0.0283 0.0974 0.7453
Loa Loa (eye worm) phosphofructokinase 0.0124 0.0393 0.3249
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0393 1
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0062
Schistosoma mansoni cytochrome-c oxidase 0.0072 0.0206 0.1704
Onchocerca volvulus 0.0025 0.0035 0.0383
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0289 0.2212
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0374 0.1306 1
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1255 0.4518 0.4517
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0393 0.3249
Echinococcus multilocularis 0.0095 0.0289 0.0875
Mycobacterium ulcerans glutaminase 0.0283 0.0974 0.0967
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0082 0.0242 0.1725
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0064 0.0489
Onchocerca volvulus Peroxidase homolog 0.004 0.0088 0.1018
Brugia malayi hypothetical protein 0.0095 0.0289 0.239
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0003 0.0022
Brugia malayi glutaminase DH11.1 0.0283 0.0974 0.8057
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0098 0.0728
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.004 0.0089 0.0735
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0102 0.0759
Brugia malayi AMP-binding enzyme family protein 0.0024 0.003 0.0245
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0159 0.1315
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.0679 0.2055
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0065 0.0535
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0001
Echinococcus multilocularis traf and tnf receptor associated protein 0.0017 0.0003 0.0008
Brugia malayi cytochrome c oxidase subunit I 0.0032 0.006 0.0496
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0003 0.002
Mycobacterium ulcerans iron-dependent repressor and activator IdeR 0.1878 0.6792 0.6789
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0393 0.3249
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0025 0.0035 0.081
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0137 0.0982
Echinococcus multilocularis musashi 0.0028 0.0044 0.0133
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.047
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.0242 0.1833
Leishmania major pteridine reductase 1 0.0033 0.0064 0.1494
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0098 0.009
Brugia malayi cysteinyl tRNA synthetase protein 1 0.004 0.0089 0.0735
Leishmania major hypothetical protein, conserved 0.0043 0.0098 0.2288
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0095 0.0289 0.026
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0099 0.0741
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0003 0.002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0035 0.0286
Trichomonas vaginalis hypothetical protein 0.0374 0.1306 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0098 0.0095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0098 0.0807
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0245
Onchocerca volvulus 0.0047 0.0114 0.1333
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0025 0.0035 0.0265
Toxoplasma gondii exonuclease III APE 0.0082 0.0242 0.185
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0001
Schistosoma mansoni inositol monophosphatase 0.0044 0.0102 0.084
Chlamydia trachomatis dihydrofolate reductase 0.0347 0.1209 0.8999
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.003 0.0022
Treponema pallidum cation-activated repressor protein (troR) 0.1329 0.4789 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0102 0.2382
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0098 0.0747
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0022
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0027 0.0625
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0102 0.0759
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Brugia malayi mbt repeat family protein 0.0047 0.0114 0.0941
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0017 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0062
Echinococcus multilocularis deoxyribonuclease 1 2 0.0017 0.0003 0.0008
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0017 0.0003 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0027 0.0625
Schistosoma mansoni cript-related 0.0017 0.0003 0.0022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0098 0.0807
Echinococcus granulosus peroxidasin 0.004 0.0088 0.0625
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0064 0.047
Brugia malayi hypothetical protein 0.0036 0.0075 0.0619
Onchocerca volvulus 0.004 0.0088 0.1018
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0017 0.0003 0.0062
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0033 0.0064 0.0056
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0033 0.0064 0.0056
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0347 0.1209 0.1207
Schistosoma mansoni lamin 0.0028 0.0044 0.0364
Schistosoma mansoni peroxidasin 0.004 0.0088 0.0724
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0017 0.0003 0.002
Trichomonas vaginalis set domain proteins, putative 0.0245 0.0836 0.6397
Brugia malayi Inositol-1 0.0044 0.0102 0.084
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0035 0.081
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0025 0.0035 0.0286
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0095 0.0289 0.0875
Mycobacterium tuberculosis Conserved hypothetical protein 0.0095 0.0289 0.0286
Echinococcus multilocularis protoporphyrinogen oxidase 0.0095 0.0289 0.0875
Loa Loa (eye worm) hypothetical protein 0.0095 0.0289 0.239
Mycobacterium ulcerans 6-phosphofructokinase 0.0124 0.0393 0.0386
Schistosoma mansoni cytochrome c oxidase subunit I 0.0032 0.006 0.0496
Echinococcus multilocularis neutral sphingomyelinase 0.0017 0.0003 0.0008
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0003 0.0062
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0027 0.022
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0064 0.0423
Mycobacterium tuberculosis Probable oxidoreductase 0.0033 0.0064 0.0061
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.047
Echinococcus granulosus geminin 0.0171 0.0567 0.4046
Mycobacterium leprae IRON-DEPENDENT REPRESSOR AND ACTIVATOR IDER 0.1878 0.6792 0.6782
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0393 0.9207
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0022
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0025 0.0035 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0364
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0099 0.076
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0807
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0102 0.0094
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0159 0.1315
Entamoeba histolytica hypothetical protein 0.0036 0.0075 0.1849
Echinococcus granulosus tumor protein p63 0.04 0.14 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0807
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0044 0.0364
Brugia malayi Animal haem peroxidase family protein 0.004 0.0088 0.0724
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0007 0.0057
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0044 0.0364
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0098 0.0697
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0728 0.602
Chlamydia trachomatis metal ABC transporter permease 0.0384 0.1342 1
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0027 0.0625
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0035 0.0032
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0098 0.0095
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0025 0.0035 0.0818
Loa Loa (eye worm) hypothetical protein 0.0095 0.0289 0.239
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0374 0.1306 1
Echinococcus granulosus leucyl tRNA synthetase 0.004 0.0089 0.0635
Onchocerca volvulus 0.0033 0.0064 0.0733
Plasmodium falciparum cysteine--tRNA ligase 0.004 0.0089 0.0681
Giardia lamblia Cysteinyl-tRNA synthetase 0.004 0.0089 0.3609
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0017 0.0003 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0095 0.0289 0.239
Brugia malayi amine oxidase, flavin-containing family protein 0.0095 0.0289 0.239
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.003 0.0693
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0102 0.2382
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.003 0.069
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0017 0.0003 0.002
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0374 0.1306 0.1304
Echinococcus multilocularis synaptojanin 1 0.0017 0.0003 0.0008
Schistosoma mansoni cytochrome oxidase subunit 0.0079 0.023 0.1899
Leishmania major pantothenate kinase subunit, putative 0.0018 0.0006 0.0146
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0055 0.0454
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.003 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0393 0.2993
Echinococcus granulosus dihydrofolate reductase 0.0347 0.1209 0.8632
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.004 0.0089 0.0681
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.004 0.0089 0.0427
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Trypanosoma cruzi mitochondrial protein 99, putative 0.0017 0.0003 0.0062
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0035 0.0027
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0099 0.076
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0347 0.1209 0.1202
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0017 0.0003 0.0062
Schistosoma mansoni hypothetical protein 0.0171 0.0567 0.4687
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0064 0.0489
Echinococcus granulosus lamin dm0 0.0028 0.0044 0.0314
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0025 0.0035 0.0286
Toxoplasma gondii histone lysine-specific demethylase 0.0095 0.0289 0.2212
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0102 0.2537
Schistosoma mansoni cytochrome oxidase subunit 0.0079 0.023 0.1899
Trypanosoma brucei oxidoreductase-like protein 0.0033 0.0064 0.1494
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0114 0.0344
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0286
Echinococcus multilocularis peroxidasin 0.004 0.0088 0.0265
Echinococcus granulosus synaptojanin 1 0.0017 0.0003 0.0019
Toxoplasma gondii hypothetical protein 0.0044 0.0104 0.0793
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0082 0.0242 0.1999
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.135 0.4865 0.4861
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0017 0.0003 0.0062
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0102 0.2382
Mycobacterium tuberculosis Iron-dependent repressor and activator IdeR 0.1878 0.6792 0.6791
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0035 0.0027
Loa Loa (eye worm) retinol dehydrogenase 12 0.0025 0.0035 0.0286
Brugia malayi exodeoxyribonuclease III family protein 0.0082 0.0242 0.1999
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0133 0.0427 0.3266
Schistosoma mansoni amine oxidase 0.0095 0.0289 0.239
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.004 0.0089 0.2084
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0075 0.0534
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0017 0.0003 0.0062
Brugia malayi cytochrome c oxidase subunit III 0.0028 0.0045 0.0369
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0035 0.0027
Loa Loa (eye worm) dihydrofolate reductase 0.0347 0.1209 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.003 0.0022
Echinococcus granulosus lamin 0.0028 0.0044 0.0314
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0035 0.0027
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0393 1
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0088 0.0724
Mycobacterium ulcerans monoamine oxidase 0.0095 0.0289 0.0282
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0374 0.1306 0.1299
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0017 0.0003 0.0019
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0159 0.1135
Brugia malayi dihydrofolate reductase family protein 0.0347 0.1209 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0033 0.0064 0.0488
Mycobacterium ulcerans hypothetical protein 0.0024 0.003 0.0022
Entamoeba histolytica hypothetical protein 0.0036 0.0075 0.1849
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0133 0.0427 1
Onchocerca volvulus 0.0095 0.0289 0.3434
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0007 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0035 0.0027
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.004 0.0089 0.2084
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0017 0.0003 0.0022
Entamoeba histolytica hypothetical protein 0.0036 0.0075 0.1849
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0003 0.0062
Onchocerca volvulus 0.004 0.0088 0.1018
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0027 0.0019
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0035 0.081
Brugia malayi phosphofructokinase 0.0124 0.0393 0.3249
Mycobacterium tuberculosis Probable transcriptional repressor SirR 0.1878 0.6792 0.6791
Mycobacterium ulcerans lipase LipD 0.0043 0.0098 0.009
Mycobacterium ulcerans short chain dehydrogenase 0.0033 0.0064 0.0056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0003 0.0062
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0035 0.0027
Onchocerca volvulus 0.0043 0.0098 0.1139
Brugia malayi Pre-SET motif family protein 0.0031 0.0055 0.0454
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0082 0.0242 0.5664
Echinococcus multilocularis tumor protein p63 0.04 0.14 0.424
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.003 0.0022
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0003 0.0022
Leishmania major cytochrome p450-like protein 0.0023 0.0027 0.0625
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0476 0.394
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0082 0.0242 0.5664
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0133 0.0427 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0035 0.0027
Mycobacterium ulcerans cytochrome C oxidase (subunit III) CtaE 0.0072 0.0206 0.0199
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0062
Echinococcus granulosus traf and tnf receptor associated protein 0.0017 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0062
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0064 0.2564
Brugia malayi Cytochrome P450 family protein 0.0023 0.0027 0.022
Onchocerca volvulus Cytochrome c oxidase subunit 3 0.0072 0.0206 0.2439
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0033 0.0064 0.0056
Loa Loa (eye worm) cytochrome c oxidase subunit III 0.0028 0.0045 0.0369
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0027 0.022
Echinococcus granulosus cytochrome c oxidase subunit 1 0.0079 0.023 0.1639
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0393 0.3249
Plasmodium falciparum enoyl-acyl carrier reductase 0.0374 0.1306 1
Brugia malayi 6-phosphofructokinase 0.0124 0.0393 0.3249
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0088 0.0724
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0086 0.3496
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0124 0.0393 0.0364
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.004 0.0089 0.0081
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0639 0.2271 0.2269
Mycobacterium tuberculosis Conserved protein 0.0043 0.0098 0.0095
Plasmodium vivax cytochrome c oxidase subunit I 0.0079 0.023 0.1758
Echinococcus granulosus 6 phosphofructokinase 0.0124 0.0393 0.2804
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0025 0.0035 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0159 0.1315
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0095 0.0289 0.2212
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0807
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Mycobacterium ulcerans oxidoreductase 0.0095 0.0289 0.0282
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0064 0.1571
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0114 0.0941
Leishmania major cysteinyl-tRNA synthetase, putative 0.004 0.0089 0.2084
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0124 0.0393 0.039
Onchocerca volvulus 0.0245 0.0836 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0098 0.0728
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0098 0.0807
Schistosoma mansoni neutral sphingomyelinase 0.0017 0.0003 0.0022
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0159 0.0481
Mycobacterium ulcerans cytochrome C oxidase polypeptide I CtaD 0.0079 0.023 0.0222
Brugia malayi Animal haem peroxidase family protein 0.004 0.0088 0.0724
Brugia malayi jmjC domain containing protein 0.0059 0.0159 0.1315
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0289 0.2212
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0003 0.002
Toxoplasma gondii ABC1 family protein 0.0043 0.0098 0.0747
Echinococcus multilocularis 6 phosphofructokinase 0.0124 0.0393 0.1189
Plasmodium vivax cytochrome c oxidase subunit 3 0.0072 0.0206 0.1577
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0095 0.0289 0.0282
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.0242 0.1833
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0017 0.0003 0.002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0051 0.0362
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0062
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0035 0.081
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0098 0.009
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0035 0.0027
Mycobacterium ulcerans oxidoreductase 0.0025 0.0035 0.0027
Brugia malayi Cytochrome P450 family protein 0.0023 0.0027 0.022
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0003 0.0022
Onchocerca volvulus 0.0059 0.0156 0.1835
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0807
Loa Loa (eye worm) inositol-1 0.0044 0.0102 0.084
Schistosoma mansoni cysteinyl-tRNA synthetase 0.004 0.0089 0.0735
Mycobacterium tuberculosis Conserved protein 0.0043 0.0098 0.0095
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0003 0.0062
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0095 0.0289 0.2212
Leishmania major oxidoreductase-like protein 0.0033 0.0064 0.1494
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 3 0.0072 0.0206 0.1348
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0374 0.1306 1
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0025 0.0035 0.0105
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0025 0.0035 0.0265
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0137 0.0416
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0025 0.0035 0.081
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0393 0.3249
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0082 0.0242 0.5664
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0807
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0064 0.0489
Loa Loa (eye worm) cytochrome c oxidase subunit I 0.0032 0.006 0.0496
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.003 0.0027
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0114 0.0941
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0159 0.1315
Plasmodium falciparum protoporphyrinogen oxidase 0.0095 0.0289 0.2212
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0022
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0374 0.1306 0.9726
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.003 0.0693
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0025 0.0035 0.0265
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0064 0.0128
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0064 0.0489
Echinococcus multilocularis lamin 0.0028 0.0044 0.0133
Brugia malayi jmjC domain containing protein 0.0059 0.0159 0.1315
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0137 0.0982
Trypanosoma cruzi mitochondrial protein 99, putative 0.0017 0.0003 0.0062
Onchocerca volvulus 0.004 0.0088 0.1018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0055 0.0166
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0102 0.0759
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0003 0.0062
Schistosoma mansoni synaptojanin 0.0017 0.0003 0.0022
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.0679 0.4846
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0102 0.0308
Mycobacterium leprae PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) 0.0079 0.023 0.0201
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0003 0.0062
Plasmodium vivax SET domain protein, putative 0.0031 0.0055 0.042
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0137 0.1137
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0095 0.0289 0.2212
Schistosoma mansoni ap endonuclease 0.0082 0.0242 0.1999
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0003 0.0022
Trichomonas vaginalis esterase, putative 0.0043 0.0098 0.0728
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0082 0.0242 0.0239
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0035 0.0286
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0098 0.0728
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0017 0.0003 0.0062
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0114 0.0941
Loa Loa (eye worm) hypothetical protein 0.0095 0.0289 0.239
Onchocerca volvulus 0.0024 0.003 0.0323
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0099 0.076
Treponema pallidum exodeoxyribonuclease (exoA) 0.0082 0.0242 0.0499
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0114 0.0941
Brugia malayi Peroxidasin 0.004 0.0088 0.0724
Mycobacterium tuberculosis Possible oxidoreductase 0.0095 0.0289 0.0286
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0017 0.0003 0.0062
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.003 0.0022
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0086 0.2141
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0025 0.0035 0.0005
Chlamydia trachomatis cysteine--tRNA ligase 0.004 0.0089 0.061
Schistosoma mansoni ap endonuclease 0.0082 0.0242 0.1999
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.003 0.0022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0272 0.0935 0.0932
Plasmodium vivax cysteine--tRNA ligase, putative 0.004 0.0089 0.0681
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0393 0.9207
Plasmodium falciparum DNase I-like protein, putative 0.0017 0.0003 0.002
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Mycobacterium tuberculosis Conserved protein 0.0043 0.0098 0.0095
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0454
Brugia malayi CCR4 0.0017 0.0003 0.0022
Chlamydia trachomatis protoporphyrinogen oxidase 0.0095 0.0289 0.2108
Entamoeba histolytica hypothetical protein 0.0036 0.0075 0.1849
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0102 0.0778
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0003 0.0022
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.003 0.069
Chlamydia trachomatis oxoacy-ACP reductase 0.0025 0.0035 0.0203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0095 0.0289 0.239
Schistosoma mansoni intermediate filament proteins 0.0028 0.0044 0.0364
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0017 0.0003 0.002
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0133 0.0427 0.3266
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0098 0.0807
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0017 0.0003 0.0022
Schistosoma mansoni dihydrofolate reductase 0.0347 0.1209 1
Mycobacterium ulcerans transcriptional repressor SirR 0.1878 0.6792 0.6789
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0941
Mycobacterium ulcerans hypothetical protein 0.0043 0.0098 0.009
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0088 0.0724
Brugia malayi beta-lactamase family protein 0.0043 0.0098 0.0807
Schistosoma mansoni hypothetical protein 0.0171 0.0567 0.4687
Loa Loa (eye worm) glutaminase 0.0283 0.0974 0.8057
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0098 0.2288
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0639 0.2271 0.2265
Schistosoma mansoni lamin 0.0028 0.0044 0.0364
Echinococcus granulosus cysteinyl tRNA synthetase 0.004 0.0089 0.0635
Leishmania major ATP-dependent phosphofructokinase 0.0124 0.0393 0.9207
Trypanosoma brucei RNA editing exonuclease 2 0.0017 0.0003 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0024 0.003 0.0245
Onchocerca volvulus Cytochrome c oxidase subunit 1 homolog 0.0079 0.023 0.2722
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.003 0.0027
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0035 0.081
Echinococcus multilocularis cysteinyl tRNA synthetase 0.004 0.0089 0.0269
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0025 0.0035 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0055 0.0454
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Brugia malayi mbt repeat family protein 0.0047 0.0114 0.0941
Brugia malayi SWIRM domain containing protein 0.0095 0.0289 0.239
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0064 0.0489
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0017 0.0003 0.0062
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0114 0.0344
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0137 0.0416
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0393 0.2993
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.003 0.0693
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.0156 0.1288
Treponema pallidum cysteinyl-tRNA synthetase 0.004 0.0089 0.018
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0003 0.002
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0003 0.002
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0017 0.0003 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0003 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0098 0.0728
Mycobacterium ulcerans dehydrogenase 0.0095 0.0289 0.0282
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0003 0.0022
Echinococcus granulosus intermediate filament protein 0.0028 0.0044 0.0314
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0086 0.066
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.135 0.4865 0.4861
Onchocerca volvulus Chorion peroxidase homolog 0.004 0.0088 0.1018
Schistosoma mansoni nocturnin 0.0017 0.0003 0.0022
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0095 0.0289 0.2212
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0245
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.004 0.0089 0.0662
Plasmodium vivax exodeoxyribonuclease III, putative 0.0017 0.0003 0.002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0082 0.0242 0.5664
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0033 0.0064 0.1494
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0137 0.1137
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0476 0.1442
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0461 0.3294
Loa Loa (eye worm) hypothetical protein 0.0095 0.0289 0.239
Leishmania major RNA-editing complex protein MP100, putative 0.0017 0.0003 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0024 0.003 0.0245
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0017 0.0003 0.0022
Echinococcus granulosus Cytochrome c oxidase subunit III 0.0072 0.0206 0.1471
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0133 0.0427 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0007 0.0057
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0082 0.0242 1
Onchocerca volvulus 0.0043 0.0098 0.1139
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.003 0.0022
Onchocerca volvulus 0.0079 0.023 0.2722
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0393 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0035 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0393 0.2993
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0082 0.0242 0.1628
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0035 0.0027
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0017 0.0003 0.0019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0098 0.0295
Brugia malayi beta-lactamase 0.0043 0.0098 0.0807
Echinococcus multilocularis dihydrofolate reductase 0.0347 0.1209 0.366
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0035 0.0032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0055 0.042
Brugia malayi Pre-SET motif family protein 0.0215 0.0728 0.602
Loa Loa (eye worm) blistered cuticle protein 3 0.004 0.0088 0.0724
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0035 0.0032
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.0242 0.185
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0062
Plasmodium falciparum cytochrome c oxidase subunit 1 0.0079 0.023 0.1758
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0098 0.0095
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0476 0.394
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0082 0.0242 0.0234
Echinococcus granulosus neutral sphingomyelinase 0.0017 0.0003 0.0019
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0102 0.0726
Brugia malayi 6-phosphofructokinase 0.0124 0.0393 0.3249
Brugia malayi Cytochrome P450 family protein 0.0034 0.0065 0.0535
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0098 0.2288
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0098 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0075 0.0226
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0064 0.0423
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0102 0.2382
Brugia malayi Blistered cuticle protein 3 0.004 0.0088 0.0724
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0035 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.003 0.069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0055 0.0454
Schistosoma mansoni synaptojanin 0.0017 0.0003 0.0022
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0035 0.0027
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0017 0.0003 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0922 0.3303 1
Onchocerca volvulus Peroxidase homolog 0.004 0.0088 0.1018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.0242 0.185
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0085 0.0082
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0035 0.0032
Mycobacterium tuberculosis Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1) 0.0079 0.023 0.0227
Brugia malayi beta-lactamase family protein 0.0043 0.0098 0.0807
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0003 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0027 0.022
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0017 0.0003 0.0022
Trypanosoma cruzi UDP-galactopyranose mutase 0.0095 0.0289 0.6773
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0062
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0114 0.0812
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0025 0.0035 0.0032
Schistosoma mansoni inositol monophosphatase 0.0044 0.0102 0.084
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0082 0.0242 0.0731
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0017 0.0003 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0098 0.0095
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0374 0.1306 0.128
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0003 0.0062
Loa Loa (eye worm) glutaminase 2 0.0283 0.0974 0.8057
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0085 0.0055
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0017 0.0003 0.0062
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0017 0.0003 0.002
Brugia malayi Animal haem peroxidase family protein 0.004 0.0088 0.0724
Mycobacterium ulcerans cytochrome C oxidase polypeptide I CtaD 0.0079 0.023 0.0222
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0159 0.1135
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0098 0.0728
Plasmodium falciparum cysteine--tRNA ligase 0.004 0.0089 0.0681
Brugia malayi Animal haem peroxidase family protein 0.004 0.0088 0.0724
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0064 0.0489
Loa Loa (eye worm) hypothetical protein 0.0054 0.0137 0.1137
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0003 0.002
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.004 0.0089 0.2084
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0017 0.0003 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0055 0.0454
Leishmania major UDP-galactopyranose mutase 0.0095 0.0289 0.6773
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0098 0.0095
Schistosoma mansoni cysteinyl-tRNA synthetase 0.004 0.0089 0.0735
Schistosoma mansoni carbon catabolite repressor protein 0.0017 0.0003 0.0022
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0159 0.0481
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0347 0.1209 0.1183
Onchocerca volvulus 0.0028 0.0044 0.0496
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0025 0.0035 0.0265
Plasmodium vivax unspecified product 0.0072 0.0206 0.1577
Mycobacterium leprae PROBABLE CYTOCHROME C OXIDASE (SUBUNIT III) CTAE 0.0072 0.0206 0.0177
Loa Loa (eye worm) hypothetical protein 0.004 0.0089 0.0735
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0003 0.0062
Onchocerca volvulus 0.004 0.0089 0.1034
Onchocerca volvulus 0.0028 0.0044 0.0496
Toxoplasma gondii hypothetical protein 0.0044 0.0104 0.0793
Mycobacterium ulcerans beta-lactamase 0.0043 0.0098 0.009
Brugia malayi intermediate filament protein 0.0028 0.0044 0.0364
Schistosoma mansoni amine oxidase 0.0095 0.0289 0.239
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.047
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.047
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.047
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0075 0.0619
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0003 0.0062
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0035 0.0027
Schistosoma mansoni cytochrome oxidase subunit 0.0079 0.023 0.1899
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.004 0.0089 0.2211
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0017 0.0003 0.002
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0003 0.0062
Toxoplasma gondii cytochrome c oxidase subunit iii subfamily protein 0.0072 0.0206 0.1577
Brugia malayi Dihydrofolate reductase 0.0347 0.1209 1
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0114 0.0812
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0095 0.0289 0.239
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0095 0.0289 0.2212
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0044 0.0364
Onchocerca volvulus Peroxidasin homolog 0.004 0.0088 0.1018
Schistosoma mansoni cytochrome c oxidase subunit III 0.0028 0.0045 0.0369
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0082 0.0242 0.6126
Schistosoma mansoni glutaminase 0.0283 0.0974 0.8057
Leishmania major endonuclease/exonuclease protein-like protein 0.0017 0.0003 0.0062
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0095 0.0289 0.239
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0098 0.0095
Trypanosoma cruzi UDP-galactopyranose mutase 0.0095 0.0289 0.6773
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0393 0.2993
Schistosoma mansoni dihydropteridine reductase 0.0025 0.0035 0.0286
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0098 0.2288
Schistosoma mansoni hypothetical protein 0.0303 0.1045 0.8648
Loa Loa (eye worm) acetyltransferase 0.0146 0.0476 0.394
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0055 0.0166
Echinococcus granulosus lysine specific histone demethylase 1A 0.0095 0.0289 0.2063
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0098 0.0095
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0003 0.0022
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0035 0.0032
Schistosoma mansoni peroxidasin 0.004 0.0088 0.0724
Echinococcus multilocularis geminin 0.0171 0.0567 0.1715
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0055 0.0392
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0064 0.0489
Brugia malayi hypothetical protein 0.004 0.0088 0.0724
Loa Loa (eye worm) oxidoreductase 0.0025 0.0035 0.0286
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0124 0.0393 0.0815
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0088 0.0724
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0099 0.0741
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0064 0.047
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0003 0.002
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0724
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0245
Onchocerca volvulus 0.0043 0.0098 0.1139
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0114 0.1333
Schistosoma mansoni cytochrome oxidase subunit 0.0079 0.023 0.1899
Onchocerca volvulus Dual oxidase homolog 0.004 0.0088 0.1018
Loa Loa (eye worm) MBCTL1 0.0054 0.0137 0.1137
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0025 0.0035 0.0032
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0099 0.0709
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0035 0.0027
Onchocerca volvulus Peroxidasin homolog 0.004 0.0088 0.1018
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0349
Onchocerca volvulus 0.0031 0.0055 0.0627
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0025 0.0035 0.0247
Mycobacterium leprae Probable lipase LipE 0.0043 0.0098 0.0068
Echinococcus multilocularis lamin dm0 0.0028 0.0044 0.0133

Activities

Activity type Activity value Assay description Source Reference
MFC (functional) = 50 uM Fungicidal activity against Candida albicans SC5314 assessed as concentration required to less than 0.1% survival of organism after 2 hrs ChEMBL. 21576022

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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