Detailed view for CaO19.8122

Basic information

TDR Targets ID: 651431
Candida albicans, Bifunctional transforymlase/cyclohydrolase
Source Database / ID:  KEGG  

pI: 6.5127 | Length (AA): 592 | MW (Da): 64940 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01808   AICARFT/IMPCHase bienzyme
PF02142   MGS-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004643   phosphoribosylaminoimidazolecarboxamide formyltransferase activity  
GO:0003937   IMP cyclohydrolase activity  
GO:0003824   catalytic activity  
GO:0006164   purine nucleotide biosynthetic process  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127961)

Species Accession Gene Product
Arabidopsis thaliana AT2G35040   AICARFT/IMPCHase bienzyme family protein
Candida albicans CaO19.492   Bifunctional transforymlase/cyclohydrolase
Candida albicans CaO19.8122   Bifunctional transforymlase/cyclohydrolase
Dictyostelium discoideum DDB_G0277087   AICAR transformylase / IMP cyclohydrolase
Drosophila melanogaster Dmel_CG11089   CG11089 gene product from transcript CG11089-RA
Escherichia coli b4006   fused IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase
Homo sapiens ENSG00000138363   5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Mycobacterium leprae ML0161   Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transf
Mus musculus ENSMUSG00000026192   5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Mycobacterium tuberculosis Rv0957   Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transfo
Mycobacterium ulcerans MUL_4712   bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
Oryza sativa 4344931   Os08g0206600
Saccharomyces cerevisiae YLR028C   bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16
Saccharomyces cerevisiae YMR120C   bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17
Schmidtea mediterranea mk4.001379.09   Bifunctional purine biosynthesis protein PURH
Schmidtea mediterranea mk4.001379.10   Bifunctional purine biosynthesis protein PURH
Wolbachia endosymbiont of Brugia malayi Wbm0411   AICAR transformylase/IMP cyclohydrolase PurH

Essentiality

CaO19.8122 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu972 Mycobacterium tuberculosis essential nmpdr
b4006 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Compounds References
Mus musculus 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.8122 (Candida albicans), Bifunctional transforymlase/cyclohydrolase
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