Detailed view for TVAG_127940

Basic information

TDR Targets ID: 850851
Trichomonas vaginalis, transcriptional adaptor, putative
Source Database / ID: 

pI: 5.1617 | Length (AA): 434 | MW (Da): 50076 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00249   Myb-like DNA-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127420)

Species Accession Gene Product
Arabidopsis thaliana AT3G07740   transcriptional adapter ADA2a
Arabidopsis thaliana AT4G16420   transcriptional adapter ADA2b
Babesia bovis BBOV_IV001060   conserved hypothetical protein
Babesia bovis BBOV_IV011130   ADA2-like protein, putative
Candida albicans CaO19.2331   transcription factor
Candida albicans CaO19.9867   transcription factor
Cryptosporidium hominis Chro.40107   ADA2-like protein
Cryptosporidium parvum cgd4_880   ADA2 ortholog with a ZZ finger, SANT domain and a SWIRM domain
Dictyostelium discoideum DDB_G0280079   SWIRM domain-containing protein
Drosophila melanogaster Dmel_CG43663   transcriptional Adaptor 2a
Drosophila melanogaster Dmel_CG9638   transcriptional Adaptor 2b
Echinococcus granulosus EgrG_000859000   Transcriptional adapter 2B
Echinococcus granulosus EgrG_000243100   transcriptional adapter 2 beta
Entamoeba histolytica EHI_142140   transcriptional adaptor ADA2, putative
Echinococcus multilocularis EmuJ_000243100   transcriptional adapter 2 beta
Echinococcus multilocularis EmuJ_000859000   Transcriptional adapter 2B
Homo sapiens ENSG00000276234   transcriptional adaptor 2A
Homo sapiens ENSG00000173011   transcriptional adaptor 2B
Mus musculus ENSMUSG00000029196   transcriptional adaptor 2B
Mus musculus ENSMUSG00000018651   transcriptional adaptor 2A
Neospora caninum NCLIV_059260   hypothetical protein
Oryza sativa 4334126   Os03g0750800
Plasmodium berghei PBANKA_1213000   transcriptional coactivator ADA2, putative
Plasmodium falciparum PF3D7_1014600   transcriptional coactivator ADA2
Plasmodium knowlesi PKNH_0814700   transcriptional coactivator ADA2, putative
Plasmodium vivax PVX_094945   transcriptional coactivator ADA2, putative
Plasmodium yoelii PY03808   ADA2-like protein
Saccharomyces cerevisiae YDR448W   Ada2p
Schistosoma japonicum Sjp_0028600   ko:K00653 histone acetyltransferase [EC2.3.1.48], putative
Schistosoma mansoni Smp_004040   transcriptional adaptor 2 (ada2)-related
Schmidtea mediterranea mk4.000259.05   Transcriptional adapter 2-beta
Toxoplasma gondii TGME49_217050   ADA2-A transcriptional co-activator SAGA component
Theileria parva TP01_0779   transcriptional adapter 2 protein, putative
Theileria parva TP01_0128   hypothetical protein
Trichomonas vaginalis TVAG_383990   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_004230   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_107380   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_140100   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_486940   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_127940   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_164270   transcriptional adaptor, putative

Essentiality

TVAG_127940 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1213000 Plasmodium berghei Essential plasmo
TGME49_217050 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_127940 (Trichomonas vaginalis), transcriptional adaptor, putative
Title for this comment
Comment