Detailed view for LOAG_05038

Basic information

TDR Targets ID: 938767
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.2913 | Length (AA): 316 | MW (Da): 34903 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02574   Homocysteine S-methyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0047150   betaine-homocysteine S-methyltransferase activity  
GO:0005737   cytoplasm  
GO:0008270   zinc ion binding  
GO:0009086   methionine biosynthetic process  

Metabolic Pathways

Cysteine and methionine metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 301 5dmm (A) 14 306 35.00 0 1 1.37968 -0.96
8 312 1umy (A) 20 321 22.00 0 1 1.08039 0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128779)

Species Accession Gene Product
Arabidopsis thaliana AT3G25900   homocysteine S-methyltransferase 1
Arabidopsis thaliana AT3G22740   homocysteine S-methyltransferase 3
Arabidopsis thaliana AT3G63250   homocysteine S-methyltransferase 2
Brugia malayi Bm1_40665   probable homocysteine S-methyltransferase
Candida albicans CaO19.386   S-adenosylmethionine:homocysteine S-methyltransferase
Candida albicans CaO19.8016   S-adenosylmethionine:homocysteine S-methyltransferase
Caenorhabditis elegans CELE_T13G4.4   Protein T13G4.4
Drosophila melanogaster Dmel_CG10623   CG10623 gene product from transcript CG10623-RC
Drosophila melanogaster Dmel_CG10621   CG10621 gene product from transcript CG10621-RA
Escherichia coli b0261   CP4-6 prophage
Leishmania braziliensis LbrM.35.6610   homocysteine S-methyltransferase, putative
Leishmania donovani LdBPK_366570.1   homocysteine S-methyltransferase, putative
Leishmania major LmjF.36.6310   homocysteine S-methyltransferase, putative
Leishmania mexicana LmxM.36.6310   homocysteine S-methyltransferase, putative
Loa Loa (eye worm) LOAG_05038   hypothetical protein
Mycobacterium leprae ML1478   PROBABLE HOMOCYSTEINE S-METHYLTRANSFERASE MMUM (S-METHYLMETHIONINE:HOMOCYSTEINE METHYLTRANSFERASE) (CYSTEINE METHYLTRANSFERASE)
Mycobacterium tuberculosis Rv2458   Probable homocysteine S-methyltransferase MmuM (S-methylmethionine:homocysteine methyltransferase) (cysteine methyltransferase)
Neospora caninum NCLIV_028500   GJ17676, related
Oryza sativa 4348656   Os10g0422200
Oryza sativa 4352747   Os12g0607000
Oryza sativa 4332095   Os03g0221200
Oryza sativa 4324713   Os01g0772900
Onchocerca volvulus OVOC5306  
Saccharomyces cerevisiae YPL273W   Sam4p
Saccharomyces cerevisiae YLL062C   Mht1p
Schistosoma japonicum Sjp_0063340   ko:K00547 homocysteine S-methyltransferase [EC2.1.1.10], putative
Schistosoma japonicum Sjp_0063350   Transmembrane protein 185B, putative
Schistosoma mansoni Smp_147610   hypothetical protein
Schmidtea mediterranea mk4.001783.04  
Trypanosoma brucei gambiense Tbg972.1.590   homocysteine S-methyltransferase, putative
Trypanosoma brucei Tb927.1.1270   homocysteine S-methyltransferase, putative
Trypanosoma congolense TcIL3000_0_17710   homocysteine S-methyltransferase, putative
Trypanosoma congolense TcIL3000_1_760   homocysteine S-methyltransferase, putative
Trypanosoma cruzi TcCLB.506479.120   cytidine triphosphate synthase, putative
Trypanosoma cruzi TcCLB.508993.20   homocysteine S-methyltransferase, putative
Toxoplasma gondii TGME49_257750   homocysteine s-methyltransferase domain-containing protein

Essentiality

LOAG_05038 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.1270 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.1.1270 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.1.1270 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.1270 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0261 Escherichia coli non-essential goodall
TGME49_257750 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0053 1 1
0.0072 0.2575 0.2575

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_05038 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment